Nlk Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Nlk
nemo like kinase
MGI:1201387

26 phenotypes from 5 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Nlk^{Gt(RRJ297)Byg}/Nlk⁺ B6.129P2-Nlk^{Gt(RRJ297)Byg}	impaired coordination	J:198661
Nlk^{Gt(RRJ297)Byg}/Nlk^Gt(XN619)Byg 129S6.129P2-Nlk^{Gt(RRJ297)Byg}/Nlk^Gt(XN619)Byg	abnormal behavior	J:198661
	premature death	J:198661
Nlk^{Gt(RRJ297)Byg}/Nlk^Gt(XN619)Byg B6.129P2-Nlk^{Gt(RRJ297)Byg}/Nlk^Gt(XN619)Byg	neonatal lethality, complete penetrance	J:198661
Nlk^tm1.1Ecan/Nlk^tm1.1Ecan involves: 129 * 129S4/SvJaeSor * C57BL/6	no abnormal phenotype detected	J:101977
Nlk^tm1Tbo/Nlk^tm1Tbo 129S1/Sv-Nlk^tm1Tbo	abnormal bone marrow development	J:73353
	abnormal definitive hematopoiesis	J:73353
	abnormal immune system organ morphology	J:73353
	ataxia	J:73353
	decreased bone marrow cell number	J:73353
	decreased double-positive T cell number	J:73353
	decreased gamma-delta T cell number	J:73353
	decreased lymphocyte cell number	J:73353
	decreased NK cell number	J:73353
	decreased pro-B cell number	J:73353
	decreased thymocyte number	J:73353
	impaired myelopoiesis	J:73353
	postnatal growth retardation	J:73353
	premature death	J:73353
	small lymph nodes	J:73353
	spleen hypoplasia	J:73353
	thymus hypoplasia	J:73353
Nlk^tm1Tbo/Nlk^tm1Tbo involves: 129S1/Sv * C57BL/6	prenatal lethality, complete penetrance	J:73353
Nlk^{tm2b(KOMP)Wtsi}/Nlk⁺ C57BL/6N-Nlk^{tm2b(KOMP)Wtsi}/Orl	abnormal auditory brainstem response	J:211773
	increased circulating alkaline phosphatase level	J:211773
	increased startle reflex	J:211773
Nlk^{tm2b(KOMP)Wtsi}/Nlk^{tm2b(KOMP)Wtsi} C57BL/6N-Nlk^{tm2b(KOMP)Wtsi}/Orl	preweaning lethality, complete penetrance	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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