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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Sh2b1
SH2B adaptor protein 1
MGI:1201407
37 phenotypes from 4 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Sh2b1em1(IMPC)Ics/Sh2b1+
C57BL/6N-Sh2b1em1(IMPC)Ics/Ics 		impaired glucose tolerance J:211773
Sh2b1tm1Ayos/Sh2b1tm1Ayos
involves: C57BL/6 		abnormal epididymis morphology J:78931
abnormal oocyte morphology J:78931
abnormal ovarian folliculogenesis J:78931
abnormal uterus development J:78931
absent tertiary ovarian follicles J:78931
asthenozoospermia J:78931
decreased body weight J:78931
decreased Leydig cell number J:78931
decreased ovary weight J:78931
decreased ovulation rate J:78931
decreased superovulation rate J:78931
decreased testis weight J:78931
normal endocrine/exocrine gland phenotype J:78931
normal immune system phenotype J:78931
increased secondary ovarian follicle number J:78931
neonatal lethality, incomplete penetrance J:78931
oligozoospermia J:78931
ovary hypoplasia J:78931
postnatal growth retardation J:78931
proportional dwarf J:78931
reduced female fertility J:78931
reduced male fertility J:78931
testis hypoplasia J:78931
Sh2b1tm1Lr/Sh2b1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		hyperglycemia J:92794
Sh2b1tm1Lr/Sh2b1tm1Lr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		decreased body size J:92794
hyperglycemia J:92794
impaired glucose tolerance J:92794
insulin resistance J:92794
pancreatic islet hyperplasia J:92794
reduced fertility J:92794
Sh2b1tm2.1Lr/Sh2b1tm2.1Lr
Tg(Pdx1-cre)89.1Dam/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL 		abnormal pancreatic beta cell physiology J:209019
decreased circulating insulin level J:209019
decreased insulin secretion J:209019
decreased pancreatic beta cell mass J:209019
normal homeostasis/metabolism phenotype J:209019
impaired glucose tolerance J:209019
increased circulating glucose level J:209019
increased pancreatic beta cell proliferation J:209019
small pancreatic islets J:209019
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory