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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Pknox1
Pbx/knotted 1 homeobox
MGI:1201409
53 phenotypes from 7 alleles in 11 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Alpltm1(cre)Nagy/Alpl+
Pknox1tm1.1Rygo/Pknox1tm1.1Rygo
involves: 129 * C57BL/6 * C57BL/6JJcl 		abnormal spermatogonia morphology J:258387
abnormal spermatogonia proliferation J:258387
arrest of spermatogenesis J:258387
azoospermia J:258387
decreased male germ cell number J:258387
decreased testis weight J:258387
increased male germ cell apoptosis J:258387
seminiferous tubule degeneration J:258387
small testis J:258387
Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+
Pknox1tm1.1Rygo/Pknox1tm1.1Rygo
involves: 129 * C57BL/6 * C57BL/6JJcl 		abnormal spermatogonia morphology J:258387
arrest of spermatogenesis J:258387
azoospermia J:258387
decreased male germ cell number J:258387
increased testis apoptosis J:258387
normal reproductive system phenotype J:258387
seminiferous tubule degeneration J:258387
Pknox1Gt(OST71835)Lex/Pknox1Gt(OST71835)Lex
B6.129S5-Pknox1Gt(OST71835)Lex 		abnormal erythropoiesis J:111418
abnormal eye development J:111418
abnormal eye morphology J:111418
abnormal liver development J:111418
abnormal prenatal growth/weight/body size J:111418
abnormal retina neuronal layer morphology J:111418
abnormal retina pigment epithelium morphology J:111418
anemia J:111418
decreased angiogenesis J:111418
decreased erythroid progenitor cell number J:111418
decreased fetal size J:111418
decreased hematocrit J:111418
edema J:111418
hemorrhage J:111418
increased nucleated erythrocyte cell number J:111418
pallor J:111418
perinatal lethality, complete penetrance J:111418
small lens J:111418
Pknox1Gt(OST71835)Lex/Pknox1Gt(OST71835)Lex
involves: 129S5/SvEvBrd 		abnormal blood cell morphology/development J:192251
Pknox1Gt(OST71835)Lex/Pknox1Gt(OST71835)Lex
involves: 129S5/SvEvBrd * C57BL/6 		decreased birth body size J:103769
decreased single-positive T cell number J:103769
increased double-negative T cell number J:103769
increased T cell apoptosis J:103769
lethality throughout fetal growth and development, complete penetrance J:103769
thymus hypoplasia J:103769
Pknox1Gt(OST71835)Lex/Pknox1Gt(OST71835)Lex
involves: 129S5/SvEvBrd * C57BL/6J 		decreased body weight J:103485
decreased percent body fat/body weight J:103485
Pknox1tm1.1Xzh/Pknox1tm1.1Xzh
Tfap2atm1(cre)Moon/Tfap2a+
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 		normal vision/eye phenotype J:182769
Pknox1tm1.1Xzh/Pknox1tm1.1Xzh
Tg(Pax6-cre,GFP)1Pgr/0
involves: 129S6/SvEvTac * C57BL/6 * FVB 		no abnormal phenotype detected J:182769
Pknox1tm1.2Xzh/Pknox1tm1.2Xzh
involves: C57BL/6 		embryonic lethality, complete penetrance J:182769
Pknox1tm1Fbla/Pknox1tm1Fbla
B6.Cg-Pknox1tm1Fbla 		abnormal embryonic tissue morphology J:165811
abnormal extraembryonic tissue morphology J:165811
abnormal pluripotent precursor cell morphology J:165811
abnormal visceral endoderm morphology J:165811
absent anterior visceral endoderm J:165811
absent mesoderm J:165811
decreased embryo size J:165811
embryonic growth retardation J:165811
embryonic lethality between implantation and somite formation, complete penetrance J:165811
failure of primitive streak formation J:165811
Pknox1tm1Ngc/Pknox1tm1Ngc
Not Specified 		embryonic lethality between implantation and somite formation, complete penetrance J:111418
Pknox1tm2.1Fbla/Pknox1tm2.1Fbla
Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
involves: 129P2/OlaHsd 		decreased pre-B cell number J:192251
increased pro-B cell number J:192251
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory