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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Smad3
SMAD family member 3
MGI:1201674
93 phenotypes from 6 alleles in 10 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Amhr2tm3(cre)Bhr/Amhr2+
Smad3tm1Par/Smad3tm1Zuk
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 		normal reproductive system phenotype J:142827
Smad3em1(IMPC)H/Smad3+
C57BL/6NTac-Smad3em1(IMPC)H/H 		decreased circulating alkaline phosphatase level J:211773
decreased lymphocyte cell number J:211773
Smad3em1(IMPC)H/Smad3em1(IMPC)H
C57BL/6NTac-Smad3em1(IMPC)H/H 		preweaning lethality, complete penetrance J:211773
Smad3tm1Cxd/Smad3tm1Cxd
B6.129S6-Smad3tm1Cxd 		abnormal vascular wound healing J:108527
decreased renal tubule apoptosis J:102084
decreased susceptibility to injury J:102084
renal interstitial fibrosis J:102084
normal renal/urinary system phenotype J:102084
tubulointerstitial nephritis J:102084
Smad3tm1Cxd/Smad3tm1Cxd
either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * NIH Black Swiss) 		abnormal immune system morphology J:53510
abnormal T cell activation J:53510
abnormal T cell physiology J:53510
abnormal thymus involution J:53510
colitis J:53510
decreased body size J:53510
enlarged lymph nodes J:53510
enlarged mesenteric lymph nodes J:53510
extramedullary hematopoiesis J:53510
impaired neutrophil chemotaxis J:53510
increased inflammatory response J:53510
increased intestinal adenocarcinoma incidence J:53510
increased leukocyte cell number J:53510
increased monocyte cell number J:53510
increased neutrophil cell number J:53510
kyphosis J:53510
pancreas inflammation J:53510
premature death J:53510
small intestinal inflammation J:53510
small spleen J:53510
spleen hypoplasia J:53510
stomach inflammation J:53510
thymus hypoplasia J:53510
Smad3tm1Cxd/Smad3tm1Cxd
involves: 129S6/SvEvTac 		abnormal articular cartilage morphology J:68792
abnormal cartilage morphology J:68792
abnormal chondrocyte morphology J:68792
abnormal epiphyseal plate morphology J:68792
abnormal forelimb morphology J:68792
abnormal intestine morphology J:75703
abnormal joint morphology J:68792
abnormal keratinocyte physiology J:59673
abnormal kidney epithelium morphology J:118474
abnormal leukocyte physiology J:59673
abnormal locomotor behavior J:68792
abnormal rib morphology J:68792
abnormal skeleton physiology J:68792
abnormal synovial joint capsule morphology J:68792
abnormal tarsal bone morphology J:68792
calcified joint J:68792
decreased B cell apoptosis J:140567
decreased body size J:75703
decreased body weight J:75703
decreased bone mineral density J:68792
decreased primary ovarian follicle number J:75703
decreased secondary ovarian follicle number J:75703
decreased susceptibility to injury J:118474
decreased tertiary ovarian follicle number J:75703
enhanced wound healing J:59673
impaired ovarian folliculogenesis J:75703
increased primordial ovarian follicle number J:75703
increased width of hypertrophic chondrocyte zone J:68792
kyphoscoliosis J:68792
kyphosis J:68792
osteoarthritis J:68792
premature death J:75703
reduced female fertility J:75703
Smad3tm1Cxd/Smad3tm1Cxd
involves: 129S6/SvEvTac * C57BL/6 		abnormal CD4-positive T cell differentiation J:136955
abnormal physiological response to xenobiotic J:137529
increased circulating creatinine level J:137529
increased susceptibility to kidney reperfusion injury J:137529
renal tubular necrosis J:137529
Smad3tm1Par/Smad3tm1Par
129-Smad3tm1Par/J 		abnormal circulating interleukin-6 level J:175290
abnormal cytokine secretion J:175290
decreased blood urea nitrogen level J:175290
decreased circulating creatinine level J:175290
decreased interleukin-6 secretion J:175290
decreased susceptibility to kidney reperfusion injury J:175290
increased inflammatory response J:106572
increased intestinal adenocarcinoma incidence J:106572
Smad3tm1Par/Smad3tm1Par
either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) 		abnormal fertility/fecundity J:49839
abnormal posture J:49839
decreased body size J:49839
distended abdomen J:49839
increased intestinal adenocarcinoma incidence J:49839
increased metastatic potential J:49839
intestinal obstruction J:49839
lethargy J:49839
premature death J:49839
rectal prolapse J:49839
ruffled hair J:49839
Smad3tm1Sche/Smad3tm1Sche
B6.129P2-Smad3tm1Sche 		abnormal mesangial matrix morphology J:145114
abnormal physiological response to xenobiotic J:145114
abnormal renal glomerulus basement membrane thickness J:145114
decreased blood urea nitrogen level J:145114
decreased circulating creatinine level J:145114
decreased kidney weight J:145114
increased body weight J:145114
Smad3tm1Xfw/Smad3tm1Xfw
involves: 129/Sv * C57BL/6 		abnormal B cell proliferation J:53948
abnormal carpal bone morphology J:53948
abnormal cell proliferation J:53948
abnormal cytokine secretion J:53948
abnormal rib morphology J:53948
abnormal sternum morphology J:53948
abnormal T cell proliferation J:53948
abnormal talus morphology J:53948
abnormal thoracic cage morphology J:53948
decreased body size J:53948
normal immune system phenotype J:53948
kyphosis J:53948
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory