Eomes Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Eomes
eomesodermin
MGI:1201683

49 phenotypes from 11 alleles in 12 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Eomes^{tm1.1(cre/ERT2)Sjar}/Eomes⁺ involves: 129S/SvEv	no abnormal phenotype detected	J:198846
Eomes^{tm1.1(cre/ERT2)Sjar}/Eomes^{tm1.1(cre/ERT2)Sjar} involves: 129S/SvEv	embryonic lethality between implantation and placentation	J:198846
Eomes^tm1.1Bflu/Eomes^tm1.1Bflu Tg(Cd4-cre)1Cwi/0 involves: C57BL/6 * DBA/2 * SJL	abnormal leukocyte migration	J:163822
	decreased memory T cell number	J:163822
	increased tumor incidence	J:163822
Eomes^tm1.1Rob/Eomes^tm1.1Rob involves: 129S/SvEv * C57BL/6 * CBA	abnormal trophoblast layer morphology	J:131055
	embryonic lethality between implantation and somite formation, complete penetrance	J:131055
Eomes^tm1.1Whk/Eomes^tm1.1Whk Tg(Six3-cre)69Frty/0 involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * DBA/2	abnormal optic nerve morphology	J:130570
	abnormal retina ganglion cell morphology	J:130570
	decreased retina ganglion cell number	J:130570
	increased retina apoptosis	J:130570
	thin retina ganglion layer	J:130570
Eomes^tm1Apr/Eomes⁺ involves: C57BL/6	decreased memory T cell number	J:112679
Eomes^tm1Apr/Eomes⁺ involves: C57BL/6	decreased NK cell number	J:112679
Eomes^tm1Apr/Eomes^tm1Apr Not Specified	abnormal anterior primitive streak morphology	J:60897
	abnormal egg cylinder morphology	J:60897
	abnormal primitive streak elongation	J:60897
	abnormal trophoblast layer morphology	J:60897
	absent mesoderm	J:60897
	absent primitive node	J:60897
	embryonic growth arrest	J:60897
	embryonic lethality between implantation and somite formation, complete penetrance	J:60897
Eomes^{tm1b(EUCOMM)Wtsi}/Eomes⁺ C57BL/6N-Eomes^{tm1b(EUCOMM)Wtsi}/H	decreased bone mineral content	J:211773
	decreased circulating creatinine level	J:211773
	decreased lean body mass	J:211773
	increased total body fat amount	J:211773
Eomes^{tm1b(EUCOMM)Wtsi}/Eomes^{tm1b(EUCOMM)Wtsi} C57BL/6N-Eomes^{tm1b(EUCOMM)Wtsi}/H	embryonic lethality prior to organogenesis	J:211773
	embryonic lethality prior to tooth bud stage	J:211773
	preweaning lethality, complete penetrance	J:211773
Eomes^tm1Jrt/Eomes^tm1Jrt either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * ICR)	absent trophectoderm	J:98502
	absent trophoblast giant cells	J:98502
	embryonic growth arrest	J:98502
	embryonic lethality before implantation, complete penetrance	J:98502
	failure of embryo implantation	J:98502
Eomes^tm1Rob/Eomes^tm1.1Rob Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ involves: 129S/SvEv * C57BL/6 * CBA	abnormal embryonic epiblast morphology	J:131055
	abnormal primitive streak morphology	J:131055
	absent mesoderm	J:131055
Eomes^tm1Rob/Eomes^tm1.1Rob Tg(T-cre)1Lwd/0 involves: 129S/SvEv * C3H * C57BL/6 * CBA	normal embryo phenotype	J:131055
Eomes^tm1Rob/Eomes^tm1Rob involves: 129S/SvEv	no abnormal phenotype detected	J:131055
Eomes^tm1Rob/Eomes^tm1Rob Sox1^tm1(cre)Take/0 involves: 129S/SvEv * C57BL/6 * CBA	abnormal axon guidance	J:138764
	abnormal dentate gyrus morphology	J:138764
	abnormal neuron apoptosis	J:138764
	abnormal neuronal precursor proliferation	J:138764
	abnormal olfactory bulb morphology	J:138764
	absent anterior commissure	J:138764
	decreased brain size	J:138764
	decreased grip strength	J:138764
	increased aggression towards humans	J:138764
	increased aggression towards mice	J:138764
	increased exploration in new environment	J:138764
	small olfactory bulb	J:138764
	thin cerebral cortex	J:138764
Eomes^tm1Rob/Eomes^tm2.1Rob Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ involves: 129S/SvEv * C57BL/6 * CBA	abnormal embryonic epiblast morphology	J:154785
	abnormal primitive streak morphology	J:154785
	failure to gastrulate	J:154785
Eomes^tm1Srnr/Eomes^tm1Srnr Tg(Cd4-cre)1Cwi/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2	decreased memory T cell number	J:137655
	normal immune system phenotype	J:137655
Eomes^tm1Whk/Eomes^tm1Whk involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J	no abnormal phenotype detected	J:130570
Eomes^tm2.1Rob/Eomes^tm2.1Rob involves: 129S/SvEv * C57BL/6	embryonic lethality between implantation and placentation, complete penetrance	J:154785

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24