Eomes Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Eomes
eomesodermin
MGI:1201683

37 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Eomes^tm1.1Bflu/Eomes^tm1.1Bflu Tbx21^tm1Glm/Tbx21^tm1Glm Tg(Cd4-cre)1Cwi/0 involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * SJL	abnormal leukocyte migration	J:163822
	decreased CD4-positive, alpha-beta T cell number	J:163822
	decreased CD8-positive, alpha-beta T cell number	J:163822
	decreased interferon-gamma secretion	J:163822
	decreased memory T cell number	J:163822
	increased interleukin-4 secretion	J:163822
	increased interleukin-17 secretion	J:163822
	increased tumor incidence	J:163822
Eomes^tm1.1Rob/Eomes⁺ Wnt3^tm1Brd/Wnt3⁺ involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * CBA	no abnormal phenotype detected	J:131055
Eomes^tm1.1Rob/Eomes⁺ Nodal^tm1Rob/Nodal⁺ involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * CBA	abnormal amniotic cavity morphology	J:131055
	abnormal anterior visceral endoderm cell migration	J:131055
	abnormal developmental patterning	J:131055
	abnormal germ layer development	J:131055
	abnormal left-right axis patterning	J:131055
	abnormal notochord morphology	J:131055
	abnormal primitive node morphology	J:131055
	abnormal rostral-caudal patterning of the somites	J:131055
	disorganized embryonic tissue	J:131055
	embryonic-extraembryonic boundary constriction	J:131055
	enlarged floor plate	J:131055
	failure of primitive streak formation	J:131055
	increased somite number	J:131055
	rostral body truncation	J:131055
	rostral-caudal axis duplication	J:131055
Eomes^tm1.1Rob/Eomes⁺ Nodal^tm4Rob/Nodal^tm4Rob involves: 129S/SvEv * C57BL/6 * CBA	no abnormal phenotype detected	J:131055
Eomes^tm1.1Twa/? Il15^tm1Imx/Il15^tm1Imx involves: C57BL/6 * C57BL/6N	abnormal NK cell differentiation	J:210160
Eomes^tm1.1Twa/? Tbx21^tm1Glm/Tbx21^tm1Glm involves: 129S6/SvEvTac * C57BL/6N	abnormal NK cell differentiation	J:210160
Eomes^tm1.1Twa/? Tg(CD2-Tbx21)#Staka/? involves: C57BL/6N	abnormal NK cell differentiation	J:210160
Eomes^tm1.1Twa/? Tg(Itgax-TGFBR2)1Flv/? involves: C3H * C57BL/6 * C57BL/6N	abnormal NK cell differentiation	J:210160
Eomes^tm1Apr/Eomes⁺ Tbx21^tm1Srnr/Tbx21^tm1Srnr involves: C57BL/6	decreased interferon-gamma secretion	J:112679
	decreased memory T cell number	J:112679
	decreased NK cell number	J:112679
	decreased NK T cell number	J:112679
Eomes^tm1Rob/Eomes⁺ Nodal^tm1Rob/Nodal⁺ Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ involves: 129S/SvEv * C57BL/6 * CBA	prenatal lethality	J:131055
	rostral body truncation	J:131055
Eomes^tm1Rob/Eomes^tm1.1Rob Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA	abnormal endoderm development	J:131055
	abnormal visceral endoderm morphology	J:131055
Eomes^tm1Srnr/Eomes^tm1Srnr Tbx21^tm1Srnr/Tbx21^tm1Srnr Tg(Cd4-cre)1Cwi/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2	abnormal CD8-positive, alpha-beta T cell differentiation	J:137655
	abnormal immune system physiology	J:137655
	abnormal interleukin level	J:137655
	abnormal leukocyte physiology	J:137655
	abnormal T cell morphology	J:137655
	decreased CD8-positive, alpha-beta T cell number	J:137655
	decreased memory T cell number	J:137655
	increased neutrophil cell number	J:137655
	increased susceptibility to Riboviria infection	J:137655

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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