Fam3d Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Fam3d
FAM3 metabolism regulating signaling molecule D
MGI:1201784

27 phenotypes from 2 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Fam3d^em1Wko/Fam3d^em1Wko C57BL/6-Fam3d^em1Wko	abnormal colon goblet cell morphology	J:300819
	abnormal colon morphology	J:300819
	abnormal crypts of Lieberkuhn morphology	J:300819
	abnormal cytokine level	J:300819
	abnormal gut flora balance	J:300819
	abnormal intestinal epithelium morphology	J:300819
	abnormal intestinal epithelium physiology	J:300819
	abnormal intestinal goblet cell physiology	J:300819
	abnormal intestinal mucosa morphology	J:300819
	abnormal neutrophil physiology	J:304594
	normal cardiovascular system phenotype	J:304594
	colitis	J:300819
	decreased colon length	J:300819
	decreased intestinal mucosa thickness	J:300819
	decreased Ly6C high monocyte number	J:304594
	decreased macrophage cell number	J:304594
	decreased neutrophil cell number	J:304594
	decreased susceptibility to injury	J:304594
	enlarged spleen	J:300819
	normal homeostasis/metabolism phenotype	J:304594
	increased incidence of tumors by chemical induction	J:300819
	increased leukocyte cell number	J:300819
	increased neutrophil cell number	J:300819, J:304594
	increased susceptibility to colitis induced morbidity/mortality	J:300819
	increased susceptibility to induced colitis	J:300819
Fam3d^tm1Lex/Fam3d^tm1Lex involves: 129S5/SvEvBrd * C57BL/6J	decreased anxiety-related response	J:171883
	decreased depression-related behavior	J:171883

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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