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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Socs3
suppressor of cytokine signaling 3
MGI:1201791
58 phenotypes from 7 alleles in 9 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Socs3tm1Ayos/Socs3tm1Ayos
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129 * C57BL/6 		decreased susceptibility to endotoxin shock J:92040
Socs3tm1Ayos/Socs3tm1Ayos
Tg(Nes-cre)1Kln/0
involves: 129 * C57BL/6 		abnormal food intake J:91796
decreased body fat mass J:91796
decreased body weight J:91796
decreased circulating free fatty acids level J:91796
decreased circulating triglyceride level J:91796
improved glucose tolerance J:91796
increased insulin sensitivity J:91796
increased response to leptin J:91796
Socs3tm1Ayos/Socs3tm1Ayos
Tg(Syn1-cre)671Jxm/0
involves: 129 * C57BL/6 		abnormal food intake J:91796
decreased body fat mass J:91796
decreased body weight J:91796
decreased circulating free fatty acids level J:91796
decreased circulating triglyceride level J:91796
improved glucose tolerance J:91796
increased insulin sensitivity J:91796
increased response to leptin J:91796
Socs3tm1Jni/Socs3+
B6.129P2-Socs3tm1Jni 		decreased susceptibility to diet-induced obesity J:91797
improved glucose tolerance J:91797
increased insulin sensitivity J:91797
Socs3tm1Jni/Socs3+
involves: 129P2/OlaHsd 		increased interleukin-2 secretion J:128797
Socs3tm1Jni/Socs3+
involves: 129P2/OlaHsd * C57BL/6 		decreased circulating leptin level J:91797
decreased susceptibility to diet-induced obesity J:91797
decreased total body fat amount J:91797
increased response to leptin J:91797
Socs3tm1Jni/Socs3tm1Jni
involves: 129P2/OlaHsd 		abnormal embryonic erythropoiesis J:57476
abnormal liver morphology J:57476
decreased embryo size J:57476
embryonic lethality during organogenesis, incomplete penetrance J:57476
normal hematopoietic system phenotype J:57476
increased erythrocyte cell number J:57476
increased nucleated erythrocyte cell number J:57476
lethality throughout fetal growth and development, incomplete penetrance J:57476
reddish skin J:57476
Socs3tm1Jni/Socs3tm1Jni
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 		abnormal placenta labyrinth morphology J:112739
Socs3tm1Robb/Socs3tm1Robb
involves: C57BL/6 		abnormal blood cell morphology/development J:145513
abnormal bone marrow cell physiology J:145513
enlarged spleen J:145513
increased neutrophil cell number J:145513
increased susceptibility to induced arthritis J:145513
Socs3tm1Wsa/Socs3tm1Wsa
either: C57BL/6-Socs3tm1Wsa or (involves: 129 * C57BL/6) 		abnormal placenta development J:70667
abnormal placenta labyrinth morphology J:70667
abnormal placenta vasculature J:70667
abnormal placental labyrinth vasculature morphology J:70667
decreased embryo size J:70667
decreased spongiotrophoblast cell number J:70667
decreased spongiotrophoblast size J:70667
embryonic lethality during organogenesis, complete penetrance J:70667
increased trophoblast giant cell number J:70667
liver hypoplasia J:70667
small liver J:70667
Socs3tm1Wsa/Socs3tm2.1Wsa
involves: C57BL/6 		absent spongiotrophoblast J:83645
embryonic lethality during organogenesis, complete penetrance J:83645
increased trophoblast giant cell number J:83645
Socs3tm1Wsa/Socs3tm2Wsa
Lyz2tm1(cre)Ifo/?
involves: 129P2/OlaHsd * C57BL/6 		abnormal macrophage physiology J:83645
Socs3tm1Wsa/Socs3tm2Wsa
Tg(Alb1-cre)1Dlr/0
involves: C57BL/6 * FVB/N 		no abnormal phenotype detected J:83645
Socs3tm1Wsa/Socs3tm2Wsa
Tg(Vav1-cre)1Awr/0
involves: C57BL/6 		abnormal definitive hematopoiesis J:89785
abnormal erythropoiesis J:89785
abnormal granulocyte differentiation J:89785
abnormal hematopoietic stem cell morphology J:89785
abnormal myelopoiesis J:89785
enlarged spleen J:89785
extramedullary hematopoiesis J:89785
increased inflammatory response J:89785
increased neutrophil cell number J:89785
liver inflammation J:89785
lung inflammation J:89785
peritoneal inflammation J:89785
Socs3tm2.1Wsa/Socs3tm2.1Wsa
involves: C57BL/6 		abnormal placenta morphology J:83645
prenatal lethality J:83645
Tg(Lck-Socs3)1Kubo/0
Not Specified 		abnormal CD4-positive T cell differentiation J:132905
decreased interleukin-2 secretion J:128797
decreased susceptibility to experimental autoimmune encephalomyelitis J:132905
decreased T cell number J:128797
decreased T cell proliferation J:128797
decreased thymocyte number J:128797
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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10/29/2024
MGI 6.24 		The Jackson Laboratory