Socs3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Socs3
suppressor of cytokine signaling 3
MGI:1201791

58 phenotypes from 7 alleles in 9 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Socs3^tm1Ayos/Socs3^tm1Ayos Lyz2^tm1(cre)Ifo/Lyz2⁺ involves: 129 * C57BL/6	decreased susceptibility to endotoxin shock	J:92040
Socs3^tm1Ayos/Socs3^tm1Ayos Tg(Nes-cre)1Kln/0 involves: 129 * C57BL/6	abnormal food intake	J:91796
	decreased body fat mass	J:91796
	decreased body weight	J:91796
	decreased circulating free fatty acids level	J:91796
	decreased circulating triglyceride level	J:91796
	improved glucose tolerance	J:91796
	increased insulin sensitivity	J:91796
	increased response to leptin	J:91796
Socs3^tm1Ayos/Socs3^tm1Ayos Tg(Syn1-cre)671Jxm/0 involves: 129 * C57BL/6	abnormal food intake	J:91796
	decreased body fat mass	J:91796
	decreased body weight	J:91796
	decreased circulating free fatty acids level	J:91796
	decreased circulating triglyceride level	J:91796
	improved glucose tolerance	J:91796
	increased insulin sensitivity	J:91796
	increased response to leptin	J:91796
Socs3^tm1Jni/Socs3⁺ B6.129P2-Socs3^tm1Jni	decreased susceptibility to diet-induced obesity	J:91797
	improved glucose tolerance	J:91797
	increased insulin sensitivity	J:91797
Socs3^tm1Jni/Socs3⁺ involves: 129P2/OlaHsd	increased interleukin-2 secretion	J:128797
Socs3^tm1Jni/Socs3⁺ involves: 129P2/OlaHsd * C57BL/6	decreased circulating leptin level	J:91797
	decreased susceptibility to diet-induced obesity	J:91797
	decreased total body fat amount	J:91797
	increased response to leptin	J:91797
Socs3^tm1Jni/Socs3^tm1Jni involves: 129P2/OlaHsd	abnormal embryonic erythropoiesis	J:57476
	abnormal liver morphology	J:57476
	decreased embryo size	J:57476
	embryonic lethality during organogenesis, incomplete penetrance	J:57476
	normal hematopoietic system phenotype	J:57476
	increased erythrocyte cell number	J:57476
	increased nucleated erythrocyte cell number	J:57476
	lethality throughout fetal growth and development, incomplete penetrance	J:57476
	reddish skin	J:57476
Socs3^tm1Jni/Socs3^tm1Jni involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6	abnormal placenta labyrinth morphology	J:112739
Socs3^tm1Robb/Socs3^tm1Robb involves: C57BL/6	abnormal blood cell morphology/development	J:145513
	abnormal bone marrow cell physiology	J:145513
	enlarged spleen	J:145513
	increased neutrophil cell number	J:145513
	increased susceptibility to induced arthritis	J:145513
Socs3^tm1Wsa/Socs3^tm1Wsa either: C57BL/6-Socs3^tm1Wsa or (involves: 129 * C57BL/6)	abnormal placenta development	J:70667
	abnormal placenta labyrinth morphology	J:70667
	abnormal placenta vasculature	J:70667
	abnormal placental labyrinth vasculature morphology	J:70667
	decreased embryo size	J:70667
	decreased spongiotrophoblast cell number	J:70667
	decreased spongiotrophoblast size	J:70667
	embryonic lethality during organogenesis, complete penetrance	J:70667
	increased trophoblast giant cell number	J:70667
	liver hypoplasia	J:70667
	small liver	J:70667
Socs3^tm1Wsa/Socs3^tm2.1Wsa involves: C57BL/6	absent spongiotrophoblast	J:83645
	embryonic lethality during organogenesis, complete penetrance	J:83645
	increased trophoblast giant cell number	J:83645
Socs3^tm1Wsa/Socs3^tm2Wsa Lyz2^tm1(cre)Ifo/? involves: 129P2/OlaHsd * C57BL/6	abnormal macrophage physiology	J:83645
Socs3^tm1Wsa/Socs3^tm2Wsa Tg(Alb1-cre)1Dlr/0 involves: C57BL/6 * FVB/N	no abnormal phenotype detected	J:83645
Socs3^tm1Wsa/Socs3^tm2Wsa Tg(Vav1-cre)1Awr/0 involves: C57BL/6	abnormal definitive hematopoiesis	J:89785
	abnormal erythropoiesis	J:89785
	abnormal granulocyte differentiation	J:89785
	abnormal hematopoietic stem cell morphology	J:89785
	abnormal myelopoiesis	J:89785
	enlarged spleen	J:89785
	extramedullary hematopoiesis	J:89785
	increased inflammatory response	J:89785
	increased neutrophil cell number	J:89785
	liver inflammation	J:89785
	lung inflammation	J:89785
	peritoneal inflammation	J:89785
Socs3^tm2.1Wsa/Socs3^tm2.1Wsa involves: C57BL/6	abnormal placenta morphology	J:83645
Socs3^tm2.1Wsa/Socs3^tm2.1Wsa involves: C57BL/6	prenatal lethality	J:83645
Tg(Lck-Socs3)1Kubo/0 Not Specified	abnormal CD4-positive T cell differentiation	J:132905
	decreased interleukin-2 secretion	J:128797
	decreased susceptibility to experimental autoimmune encephalomyelitis	J:132905
	decreased T cell number	J:128797
	decreased T cell proliferation	J:128797
	decreased thymocyte number	J:128797

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