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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Chek1
checkpoint kinase 1
MGI:1202065
24 phenotypes from 4 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Chek1tm1Jmr/Chek1+
Tg(Wap-cre)11738Mam/0
involves: C57BL/6 		increased cell proliferation J:91266
Chek1tm1Jmr/Chek1+
Tg(Dct-lacZ)A12Jkn/0
Tg(Tyr-cre)1Lru/Y
involves: C57BL/6 * CBA * DBA/2 		abnormal melanoblast morphology J:265850
normal pigmentation phenotype J:265850
Chek1tm1Jmr/Chek1tm1Jmr
Tg(Dct-lacZ)A12Jkn/0
Tg(Tyr-cre)1Lru/Y
involves: C57BL/6 * CBA * DBA/2 		abnormal DNA replication J:265850
abnormal melanoblast morphology J:265850
Chek1tm1Jmr/Chek1tm1Jmr
Tg(Tyr-cre)1Lru/Y
involves: C57BL/6 * DBA/2 		abnormal epidermal melanocyte morphology J:265850
abnormal hair follicle melanocyte morphology J:265850
absent coat pigmentation J:265850
decreased melanocyte number J:265850
Chek1tm1Jmr/Chek1tm1Jmr
Tg(Wap-cre)11738Mam/0
involves: C57BL/6 		abnormal apoptosis J:91266
abnormal lactation J:91266
abnormal mammary gland growth during pregnancy J:91266
decreased cell proliferation J:91266
Chek1tm1Mkt/Chek1tm1Mkt
involves: 129P2/OlaHsd * C57BL/6J 		abnormal cell cycle checkpoint function J:62918
abnormal cell nucleus morphology J:62918
abnormal inner cell mass proliferation J:62918
absent inner cell mass proliferation J:62918
embryonic lethality between implantation and somite formation, complete penetrance J:62918
increased inner cell mass apoptosis J:62918
Chek1tm1Sje/Chek1+
Not Specified 		normal neoplasm J:62919
Chek1tm1Sje/Chek1tm1Sje
Not Specified 		abnormal cell cycle checkpoint function J:62919
decreased cell proliferation J:62919
embryonic lethality before implantation, complete penetrance J:62919
failure of blastocyst to hatch from the zona pellucida J:62919
increased embryonic tissue cell apoptosis J:62919
Chek1tm2.1Sje/Chek1+
Tg(MMTV-cre)#Mam/0
involves: FVB 		abnormal mammary gland alveolus morphology J:162126
abnormal mammary gland morphology J:162126
normal neoplasm J:162126
Chek1tm2.1Sje/Chek1tm2.1Sje
Tg(MMTV-cre)#Mam/0
involves: FVB 		abnormal mammary gland alveolus morphology J:162126
abnormal mammary gland morphology J:162126
normal neoplasm J:162126
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory