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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Chek1
checkpoint kinase 1
MGI:1202065
14 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Chek1tm1Sje/Chek1+
Tg(Wnt1)1Hev/0
Not Specified 		increased mammary adenocarcinoma incidence J:62919
Chek1tm1Sje/Chek1tm1Sje
Trp53tm1Brd/Trp53tm1Brd
involves: 129S7/SvEvBrd 		embryonic lethality before implantation, complete penetrance J:62919
increased apoptosis J:62919
Chek1tm2.1Sje/Chek1+
Trp53tm1Brn/Trp53+
Tg(MMTV-cre)#Mam/0
involves: 129P2/OlaHsd * FVB 		abnormal branching of the mammary ductal tree J:162126
abnormal chromosome morphology J:162126
abnormal mammary gland alveolus morphology J:162126
abnormal tumor morphology J:162126
abnormal tumor vascularization J:162126
aneuploidy J:162126
increased mammary adenocarcinoma incidence J:162126
increased mammary gland tumor incidence J:162126
mammary gland hyperplasia J:162126
Chek1tm2.1Sje/Chek1+
Trp53tm1Brn/Trp53tm1Brn
Tg(MMTV-cre)#Mam/0
involves: 129P2/OlaHsd * FVB 		abnormal mammary gland alveolus morphology J:162126
decreased tumor incidence J:162126
increased mammary gland tumor incidence J:162126
mammary gland hyperplasia J:162126
Chek1tm2.1Sje/Chek1tm2.1Sje
Trp53tm1Brn/Trp53+
Tg(MMTV-cre)#Mam/0
involves: 129P2/OlaHsd * FVB 		abnormal mammary gland alveolus morphology J:162126
increased mammary gland tumor incidence J:162126
Chek1tm2.1Sje/Chek1tm2.1Sje
Trp53tm1Brn/Trp53tm1Brn
Tg(MMTV-cre)#Mam/0
involves: 129P2/OlaHsd * FVB 		abnormal mammary gland alveolus morphology J:162126
abnormal tumor morphology J:162126
decreased tumor incidence J:162126
normal reproductive system phenotype J:162126
Mcm3tm1.1Geno/Mcm3tm1.1Geno
Tg(Chek1)1Ofc/0
involves: 129S2/SvPas * C57BL/6 * CD-1 		prenatal lethality, incomplete penetrance J:227638
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory