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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Itch
itchy, E3 ubiquitin protein ligase
MGI:1202301
67 phenotypes from 3 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Itchtm1(NCOM)Cmhd/Itch+
C57BL/6N-Itchtm1(NCOM)Cmhd/Tcp 		increased mean corpuscular volume J:165965
Itchtm1.1Alta/Itchtm1.1Alta
Foxp3tm4(YFP/icre)Ayr/Foxp3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal immunoglobulin level J:204685
abnormal interleukin secretion J:204685
abnormal lymph organ size J:204685
abnormal lymphopoiesis J:204685
abnormal regulatory T cell physiology J:204685
abnormal T-helper 2 cell differentiation J:204685
abnormal T-helper 2 physiology J:204685
decreased CD4-positive, alpha-beta T cell number J:204685
dermatitis J:204685
enlarged lymph nodes J:204685
enlarged spleen J:204685
normal immune system phenotype J:204685
increased CD4-positive, alpha-beta T cell number J:204685
increased CD8-positive, alpha-beta T cell number J:204685
increased eosinophil cell number J:204685
increased IgA level J:204685
increased IgE level J:204685
increased IgG1 level J:204685
increased inflammatory response J:204685
increased interleukin-4 secretion J:204685
increased interleukin-5 secretion J:204685
increased interleukin-10 secretion J:204685
increased interleukin-13 secretion J:204685
increased interleukin-17 secretion J:204685
increased leukocyte cell number J:204685
increased regulatory T cell apoptosis J:204685
increased regulatory T cell number J:204685
lung inflammation J:204685
premature death J:204685
skin lesions J:204685
weight loss J:204685
Itchtm1b(EUCOMM)Hmgu/Itchtm1b(EUCOMM)Hmgu
C57BL/6N-Itchtm1b(EUCOMM)Hmgu/H 		abnormal bone structure J:211773
abnormal esophagus morphology J:211773
abnormal head size J:211773
abnormal startle reflex J:211773
abnormal tooth morphology J:211773
decreased bone mineral content J:211773
decreased bone mineral density J:211773
decreased circulating alkaline phosphatase level J:211773
decreased circulating fructosamine level J:211773
decreased circulating glucose level J:211773
decreased exploration in new environment J:211773
decreased fasting circulating glucose level J:211773
decreased hematocrit J:211773
decreased hemoglobin content J:211773
decreased lymphocyte cell number J:211773
decreased mean corpuscular hemoglobin J:211773
decreased mean corpuscular volume J:211773
decreased total body fat amount J:211773
enlarged gallbladder J:211773
enlarged kidney J:211773
enlarged spleen J:211773
increased basophil cell number J:211773
increased blood urea nitrogen level J:211773
increased circulating amylase level J:211773
increased circulating aspartate transaminase level J:211773
increased circulating calcium level J:211773
increased circulating phosphate level J:211773
increased circulating total protein level J:211773
increased eosinophil cell number J:211773
increased heart weight J:211773
increased large unstained cell number J:211773
increased lean body mass J:211773
increased leukocyte cell number J:211773
increased lymphocyte cell number J:211773
increased neutrophil cell number J:211773
increased red blood cell distribution width J:211773
increased spleen weight J:211773
tremors J:211773
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory