Hcrt Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Hcrt
hypocretin
MGI:1202306

25 phenotypes from 2 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Hcrt^{tm1.1(KOMP)Vlcg}/Hcrt^{tm1.1(KOMP)Vlcg} C57BL/6N-Hcrt^{tm1.1(KOMP)Vlcg}/Ucd	decreased grip strength	J:211773
	decreased heart rate	J:211773
	decreased locomotor activity	J:211773
	increased lymphocyte cell number	J:211773
	prolonged RR interval	J:211773
Hcrt^tm1Ywa/Hcrt⁺ involves: 129S6/SvEvTac * C57BL/6	increased susceptibility to age related obesity	J:128233
Hcrt^tm1Ywa/Hcrt^tm1Ywa B6.129S6-Hcrt^tm1Ywa	abnormal circadian temperature homeostasis	J:111673
	abnormal sleep pattern	J:111673
	decreased locomotor activity	J:111673
	fragmentation of sleep/wake states	J:111673
Hcrt^tm1Ywa/Hcrt^tm1Ywa involves: 129S6/SvEvTac	abnormal gait	J:83817
	abnormal muscle tone	J:170824
	abnormal non-rapid eye movement sleep pattern	J:83817
	abnormal paradoxical sleep pattern	J:83817
	abnormal sleep pattern	J:83817
	fragmentation of sleep/wake states	J:170824
	increased frequency of paradoxical sleep	J:83817
	narcolepsy	J:83817
Hcrt^tm1Ywa/Hcrt^tm1Ywa involves: 129S6/SvEvTac * C57BL/6	abnormal gait	J:57124
	abnormal locomotor activation	J:57124, J:85405
	abnormal locomotor behavior	J:57124
	abnormal nervous system electrophysiology	J:85405
	abnormal posture	J:57124
	abnormal systemic arterial blood pressure	J:85405
	behavioral arrest	J:57124
	decreased locomotor activity	J:85405
	decreased mean systemic arterial blood pressure	J:85405
	increased heart rate	J:85405
	increased pulmonary respiratory rate	J:85405
	increased susceptibility to age related obesity	J:128233
	increased vertical activity	J:57124
	narcolepsy	J:57124

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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