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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tert
telomerase reverse transcriptase
MGI:1202709
32 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Fancctm1Mab/Fancctm1Mab
Terttm1Leah/Terttm1Leah
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal cell physiology J:157096
Pinx1tm1.1Kplu/Pinx1+
Terttm1Leah/Terttm1Leah
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * FVB/N 		normal cellular phenotype J:171997
Ptentm1Rdp/Ptentm1Rdp
Terttm1Rdp/Tert+
Trp53tm1Brn/Trp53tm1Brn
Tg(Pbsn-cre)4Prb/0
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2 		increased prostate gland adenocarcinoma incidence J:186105
increased prostate intraepithelial neoplasia incidence J:186105
premature death J:186105
Ptentm1Rdp/Ptentm1Rdp
Terttm1Rdp/Terttm1Rdp
Trp53tm1Brn/Trp53tm1Brn
Tg(Pbsn-cre)4Prb/0
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2 		decreased telomere length J:186105
decreased tumor growth/size J:186105
increased prostate intraepithelial neoplasia incidence J:186105
Ptentm1Rdp/Ptentm1Rdp
Terttm3Rdp/Terttm3Rdp
Trp53tm1Brn/Trp53tm1Brn
Tg(Pbsn-cre)4Prb/0
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2 		abnormal chromosome morphology J:186105
decreased tumor-free survival time J:186105
increased metastatic potential J:186105
increased prostate gland adenocarcinoma incidence J:186105
increased prostate intraepithelial neoplasia incidence J:186105
increased telomere length J:186105
Terctm1Rdp/Terctm1Rdp
Tg(KRT5-Tert)8043Blas/0
involves: 129/Sv * C57BL/6 * C57BL/6J * DBA/2 * SJL 		abnormal chromosome morphology J:96945
decreased incidence of tumors by chemical induction J:96945
decreased telomere length J:96945
delayed wound healing J:96945
Terttm1Rdp/Terttm1Rdp
Trp53tm1Tyj/Trp53+
B6.Cg-Trp53tm1Tyj Terttm1Rdp 		increased incidence of tumors by chemical induction J:108914
Terttm2.1Rdp/Terttm2.1Rdp
involves: C57BL/6 		abnormal chromosome morphology J:167227
abnormal corpus callosum morphology J:167227
abnormal crypts of Lieberkuhn morphology J:167227
abnormal male germ cell apoptosis J:167227
abnormal neuron differentiation J:167227
abnormal neuronal precursor proliferation J:167227
decreased brain weight J:167227
decreased litter size J:167227
decreased oligodendrocyte number J:167227
decreased spleen weight J:167227
decreased telomere length J:167227
demyelination J:167227
early cellular replicative senescence J:167227
impaired olfaction J:167227
premature death J:167227
small testis J:167227
spleen atrophy J:167227
normal taste/olfaction phenotype J:167227
testicular atrophy J:167227
Terttm2.1Sear/Terttm2.1Sear
Not Specified 		no abnormal phenotype detected J:150343
Tg(KRT5-Terf2)PMBlas/Y
Tg(KRT5-Tert)8043Blas/0
involves: C57BL/6 * CBA * DBA/2 		decreased telomere length J:102653
increased skin pigmentation J:102653
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory