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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tcf21
transcription factor 21
MGI:1202715
81 phenotypes from 6 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Tcf21em1(IMPC)Mbp/Tcf21+
C57BL/6NCrl-Tcf21em1(IMPC)Mbp/MbpMmucd 		abnormal eye morphology J:211773
abnormal kidney morphology J:211773
abnormal ovary morphology J:211773
abnormal placenta morphology J:211773
abnormal spleen morphology J:211773
abnormal testis morphology J:211773
anophthalmia J:211773
edema J:211773
embryonic growth retardation J:211773
enlarged kidney J:211773
enlarged testis J:211773
increased circulating calcium level J:211773
microphthalmia J:211773
persistence of hyaloid vascular system J:211773
small spleen J:211773
Tcf21em1(IMPC)Mbp/Tcf21em1(IMPC)Mbp
C57BL/6NCrl-Tcf21em1(IMPC)Mbp/MbpMmucd 		abnormal blood vessel morphology J:211773
abnormal placenta morphology J:211773
abnormal placenta vasculature J:211773
edema J:211773
microphthalmia J:211773
preweaning lethality, complete penetrance J:211773
Tcf21tm1Eno/Tcf21tm1Eno
involves: 129 * Black Swiss 		abnormal branching involved in lung morphogenesis J:64068
abnormal kidney development J:64068
abnormal spleen development J:64068
absent pulmonary alveoli J:64068
absent spleen J:64068
cyanosis J:64068
impaired branching involved in ureteric bud morphogenesis J:64068
neonatal lethality, complete penetrance J:64068
pallor J:64068
pulmonary hypoplasia J:64068
renal glomerulus atrophy J:64068
renal hypoplasia J:64068
respiratory distress J:64068
Tcf21tm1Jrt/Tcf21tm1Jrt
involves: 129S1/Sv * 129X1/SvJ 		abnormal branching involved in ureteric bud morphogenesis J:55785
abnormal glomerular capillary morphology J:55785
abnormal kidney development J:55785
abnormal kidney medulla morphology J:55785
abnormal kidney mesenchyme morphology J:55785
abnormal kidney vasculature morphology J:55785
abnormal lung epithelium morphology J:55785
abnormal lung vasculature morphology J:55785
abnormal ovary morphology J:92051
abnormal ovary topology J:92051
abnormal peritubular capillary morphology J:55785
abnormal podocyte foot process morphology J:55785
abnormal podocyte morphology J:55785
abnormal proximal convoluted tubule morphology J:55785
abnormal pulmonary acinus morphology J:55785
abnormal pulmonary alveolar sac morphology J:55785
abnormal renal glomerulus morphology J:55785
abnormal ureteric bud morphology J:55785
abnormal ureteric bud tip morphology J:55785
absent proximal convoluted tubule brush border J:55785
absent pulmonary alveoli J:55785
absent type II pneumocytes J:55785
decreased nephron number J:55785
decreased renal glomerulus number J:55785
delayed kidney development J:55785
dilated respiratory conducting tube J:55785
disorganized testis cords J:92051
ectopic ovary J:92051
hemopericardium J:55785
impaired branching involved in alveolar sac morphogenesis J:55785
impaired branching involved in bronchus morphogenesis J:55785
impaired branching involved in ureteric bud morphogenesis J:55785
neonatal lethality, complete penetrance J:55785
primary sex reversal J:92051
pulmonary hypoplasia J:55785
renal hypoplasia J:55785
respiratory distress J:55785
respiratory failure J:55785
secondary sex reversal J:92051
sex reversal J:92051
small gonad J:92051
small kidney J:55785
small lung J:55785
small lung lobe J:55785
Tcf21tm2.1Seq/Tcf21tm1Jrt
Tg(Nphs2-cre)1Seq/0
involves: 129S1/Sv * 129X1/SvJ 		abnormal kidney morphology J:217144
abnormal kidney physiology J:217144
abnormal podocyte morphology J:217144
abnormal renal glomerular capsule morphology J:217144
abnormal renal glomerulus morphology J:217144
abnormal urine homeostasis J:217144
glomerulosclerosis J:217144
increased urine protein level J:217144
kidney atrophy J:217144
pale kidney J:217144
podocyte foot process effacement J:217144
Tcf21tm2.1Seq/Tcf21tm1Jrt
Wnt4tm2(EGFP/cre)Svo/Wnt4+
involves: 129S1/Sv * 129X1/SvJ 		abnormal podocyte morphology J:217144
abnormal renal glomerulus morphology J:217144
small kidney J:217144
Tcf21tm2Eno/Tcf21tm2Eno
involves: 129 * Black Swiss 		abnormal branching involved in lung morphogenesis J:64068
abnormal kidney development J:64068
abnormal spleen development J:64068
absent pulmonary alveoli J:64068
absent spleen J:64068
cyanosis J:64068
impaired branching involved in ureteric bud morphogenesis J:64068
neonatal lethality, complete penetrance J:64068
pallor J:64068
pulmonary hypoplasia J:64068
renal glomerulus atrophy J:64068
renal hypoplasia J:64068
respiratory distress J:64068
Tcf21tm2Eno/Tcf21tm2Eno
involves: 129 * C57BL/6 		abnormal heart apex morphology J:185552
abnormal heart morphology J:185552
abnormal heart shape J:185552
hemopericardium J:185552
increased heart right atrium size J:185552
thin myocardium J:185552
Tcf21tm3.1(cre/Esr1*)Eno/Tcf21+
involves: 129S6/SvEvTac * C57BL/6 		no abnormal phenotype detected J:178665
Tcf21tm3.1(cre/Esr1*)Eno/Tcf21tm3.1(cre/Esr1*)Eno
involves: 129S6/SvEvTac * C57BL/6 		neonatal lethality, complete penetrance J:178665
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory