Tcf7l1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tcf7l1
transcription factor 7 like 1 (T cell specific, HMG box)
MGI:1202876

36 phenotypes from 6 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Hesx1^tm1(cre)Jpmb/Hesx1⁺ Tcf7l1^tm1Efu/Tcf7l1^tm2Efu involves: 129S/SvEv	anophthalmia	J:181005
	decreased forebrain size	J:181005
	microphthalmia	J:181005
	small embryonic telencephalon	J:181005
Tcf7l1^{tm1.1(cre/ERT2)Hng}/Tcf7l1^{tm1.1(cre/ERT2)Hng} involves: 129S4/SvJaeSor * 129S7/SvEvBrd	no abnormal phenotype detected	J:213957
Tcf7l1^tm1.1Bjme/Tcf7l1^tm1.1Bjme involves: C57BL/6	abnormal blood vessel morphology	J:185554
	abnormal eyelid development	J:185554
	abnormal limb bud morphology	J:185554
	abnormal limb development	J:185554
	dilated vasculature	J:185554
	exencephaly	J:185554
	eyelids open at birth	J:185554
	failure of eyelid fusion	J:185554
	forelimb oligodactyly	J:185554
	hydrops fetalis	J:185554
	internal hemorrhage	J:185554
	lethality throughout fetal growth and development, incomplete penetrance	J:185554
	neonatal lethality, complete penetrance	J:185554
Tcf7l1^tm1.1Efu/Tcf7l1^tm1.1Efu Tg(KRT14-cre)1Efu/0 involves: 129	no abnormal phenotype detected	J:155012
Tcf7l1^{tm1a(EUCOMM)Wtsi}/Tcf7l1⁺ B6JTyr;B6N-Tcf7l1^{tm1a(EUCOMM)Wtsi}/Wtsi	cornea opacity	J:175295
Tcf7l1^tm1Efu/Tcf7l1^tm1Efu Tg(Vil1-cre/ERT2)23Syr/0 involves: 129 * C57BL/6 * DBA/2	normal digestive/alimentary phenotype	J:185753
Tcf7l1^tm2Efu/Tcf7l1^tm2Efu involves: 129/Sv * C57BL/6	abnormal blood vessel morphology	J:90402
	abnormal brain development	J:90402
	abnormal foregut morphology	J:90402
	abnormal neural fold formation	J:90402
	abnormal notochord morphology	J:90402
	abnormal primitive streak formation	J:90402
	abnormal rostral-caudal axis patterning	J:90402
	absent heart	J:90402
	absent somites	J:90402
	decreased embryo size	J:90402
	decreased forebrain size	J:90402
	embryonic lethality during organogenesis, complete penetrance	J:90402
	enlarged heart	J:90402
	enlarged pericardium	J:90402
	increased axial mesoderm size	J:90402
	increased somite number	J:90402
	rostral body truncation	J:90402
	rostral-caudal axis duplication	J:90402

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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