Birc5 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Birc5
baculoviral IAP repeat-containing 5
MGI:1203517

32 phenotypes from 6 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Birc5^tm1Emc/Birc5⁺ involves: 129S1/Sv * 129X1/SvJ * Swiss	abnormal apoptosis	J:78103
	abnormal oxidative phosphorylation	J:78103
	increased susceptibility to injury	J:78103
Birc5^tm1Emc/Birc5^tm1Emc involves: 129S1/Sv * 129X1/SvJ * Swiss	embryonic lethality before implantation, complete penetrance	J:78103
Birc5^tm1Mak/Birc5^tm1Mak involves: 129P2/OlaHsd	no abnormal phenotype detected	J:90892
Birc5^tm1Mak/Birc5^tm1Mak Tg(Lck-cre)I57Jxm/0 involves: 129P2/OlaHsd	abnormal cell cycle	J:90892
	abnormal T cell morphology	J:90892
	abnormal thymus corticomedullary boundary morphology	J:90892
	decreased double-negative T cell number	J:90892
	decreased thymocyte number	J:90892
	increased T cell apoptosis	J:90892
	small thymus	J:90892
Birc5^tm1Vaux/Birc5^tm1Vaux C57BL/6-Birc5^tm1Vaux	abnormal cell cycle	J:86384
	abnormal cell nucleus count	J:86384
	abnormal cell nucleus morphology	J:86384
	abnormal embryonic tissue morphology	J:86384
	abnormal mitotic spindle morphology	J:86384
	absent blastocoele	J:86384
	absent trophoblast giant cells	J:86384
	binucleate	J:86384
	embryonic lethality between implantation and somite formation, complete penetrance	J:86384
	failure of blastocyst to hatch from the zona pellucida	J:86384
	inner cell mass degeneration	J:86384
Birc5^tm1Wnt/Birc5^tm1Emc Tg(Cd4-cre)1Cwi/0 involves: 129S/SvEv * C57BL/6 * DBA/2	abnormal T cell differentiation	J:87435
Birc5^tm1Wnt/Birc5^tm1Emc Tg(Lck-cre)1Cwi/0 involves: 129S/SvEv * C57BL/6 * DBA/2	decreased double-positive T cell number	J:87435
	decreased T cell number	J:87435
	increased double-negative T cell number	J:87435
	small lymph nodes	J:87435
	thymus hypoplasia	J:87435
Tg(Dct-Birc5)21Gros/0 involves: C57BL/6 * CBA	decreased cellular sensitivity to ultraviolet irradiation	J:122181
Tg(Dct-Birc5)21Gros/0 involves: C57BL/6 * CBA	normal neoplasm	J:122181
Tg(KRT14-Birc5)19Gros/0 involves: C3H * C57BL/6	abnormal keratinocyte physiology	J:81530
Tg(KRT14-Birc5)19Gros/0 involves: C3H * C57BL/6	decreased incidence of tumors by chemical induction	J:81530

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24