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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Pik3c2a
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
MGI:1203729
66 phenotypes from 3 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Pik3c2aGt(OST288105)Lex/Pik3c2aGt(OST288105)Lex
involves: 129S5/SvEvBrd * C57BL/6J 		abnormal blood homeostasis J:169710
abnormal kidney morphology J:169710
abnormal podocyte morphology J:169710
abnormal renal glomerulus morphology J:169710
decreased body size J:169710
decreased body weight J:169710
decreased circulating bilirubin level J:169710
decreased creatinine clearance J:169710
decreased erythrocyte cell number J:169710
decreased hematocrit J:169710
decreased hemoglobin content J:169710
decreased lean body mass J:169710
decreased total body fat amount J:169710
enlarged spleen J:169710
expanded mesangial matrix J:169710
glomerulonephritis J:169710
glomerulosclerosis J:169710
normal immune system phenotype J:169710
increased anti-double stranded DNA antibody level J:169710
increased B cell number J:169710
increased blood urea nitrogen level J:169710
increased CD4-positive, alpha-beta T cell number J:169710
increased CD8-positive, alpha-beta T cell number J:169710
increased circulating alkaline phosphatase level J:169710
increased circulating cholesterol level J:169710
increased circulating creatinine level J:169710
increased circulating phosphate level J:169710
increased circulating potassium level J:169710
increased granulocyte number J:169710
increased IgA level J:169710
increased IgG level J:169710
increased IgM level J:169710
increased leukocyte cell number J:169710
increased mean platelet volume J:169710
increased monocyte cell number J:169710
increased neutrophil cell number J:169710
increased urine protein level J:169710
kidney failure J:169710
pale kidney J:169710
podocyte foot process effacement J:169710
polyuria J:169710
postnatal growth retardation J:169710
premature death J:169710
small kidney J:169710
thrombocytosis J:169710
Pik3c2atm1b(EUCOMM)Hmgu/Pik3c2a+
C57BL/6N-Pik3c2atm1b(EUCOMM)Hmgu/Tcp 		decreased locomotor activity J:211773
decreased lymphocyte cell number J:211773
enlarged lymph nodes J:211773
increased neutrophil cell number J:211773
Pik3c2atm1b(EUCOMM)Hmgu/Pik3c2atm1b(EUCOMM)Hmgu
C57BL/6N-Pik3c2atm1b(EUCOMM)Hmgu/Tcp 		abnormal embryo size J:211773
embryonic growth retardation J:211773
embryonic lethality prior to tooth bud stage J:211773
preweaning lethality, complete penetrance J:211773
Pik3c2atm1Bvan/Pik3c2a+
involves: C57BL/6 		abnormal megakaryocyte morphology J:226344
abnormal plasma membrane morphology J:226344
abnormal platelet alpha-granule morphology J:226344
abnormal platelet morphology J:226344
abnormal platelet physiology J:226344
abnormal platelet shape J:226344
abnormal thrombopoiesis J:226344
normal cardiovascular system phenotype J:226344
decreased platelet aggregation J:226344
decreased platelet alpha-granule number J:226344
decreased susceptibility to induced thrombosis J:226344
normal homeostasis/metabolism phenotype J:226344
increased hematocrit J:226344
Pik3c2atm1Bvan/Pik3c2atm1Bvan
involves: C57BL/6 		prenatal lethality, complete penetrance J:226344
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory