About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Pik3c2a
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
MGI:1203729
66 phenotypes from 3 alleles in 3 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Pik3c2aGt(OST288105)Lex/Pik3c2aGt(OST288105)Lex
involves: 129S5/SvEvBrd * C57BL/6J 		abnormal blood homeostasis J:169710
abnormal kidney morphology J:169710
abnormal podocyte morphology J:169710
abnormal renal glomerulus morphology J:169710
decreased body size J:169710
decreased body weight J:169710
decreased circulating bilirubin level J:169710
decreased creatinine clearance J:169710
decreased erythrocyte cell number J:169710
decreased hematocrit J:169710
decreased hemoglobin content J:169710
decreased lean body mass J:169710
decreased total body fat amount J:169710
enlarged spleen J:169710
expanded mesangial matrix J:169710
glomerulonephritis J:169710
glomerulosclerosis J:169710
normal immune system phenotype J:169710
increased anti-double stranded DNA antibody level J:169710
increased B cell number J:169710
increased blood urea nitrogen level J:169710
increased CD4-positive, alpha-beta T cell number J:169710
increased CD8-positive, alpha-beta T cell number J:169710
increased circulating alkaline phosphatase level J:169710
increased circulating cholesterol level J:169710
increased circulating creatinine level J:169710
increased circulating phosphate level J:169710
increased circulating potassium level J:169710
increased granulocyte number J:169710
increased IgA level J:169710
increased IgG level J:169710
increased IgM level J:169710
increased leukocyte cell number J:169710
increased mean platelet volume J:169710
increased monocyte cell number J:169710
increased neutrophil cell number J:169710
increased urine protein level J:169710
kidney failure J:169710
pale kidney J:169710
podocyte foot process effacement J:169710
polyuria J:169710
postnatal growth retardation J:169710
premature death J:169710
small kidney J:169710
thrombocytosis J:169710
Pik3c2atm1b(EUCOMM)Hmgu/Pik3c2a+
C57BL/6N-Pik3c2atm1b(EUCOMM)Hmgu/Tcp 		decreased locomotor activity J:211773
decreased lymphocyte cell number J:211773
enlarged lymph nodes J:211773
increased neutrophil cell number J:211773
Pik3c2atm1b(EUCOMM)Hmgu/Pik3c2atm1b(EUCOMM)Hmgu
C57BL/6N-Pik3c2atm1b(EUCOMM)Hmgu/Tcp 		abnormal embryo size J:211773
embryonic growth retardation J:211773
embryonic lethality prior to tooth bud stage J:211773
preweaning lethality, complete penetrance J:211773
Pik3c2atm1Bvan/Pik3c2a+
involves: C57BL/6 		abnormal megakaryocyte morphology J:226344
abnormal plasma membrane morphology J:226344
abnormal platelet alpha-granule morphology J:226344
abnormal platelet morphology J:226344
abnormal platelet physiology J:226344
abnormal platelet shape J:226344
abnormal thrombopoiesis J:226344
normal cardiovascular system phenotype J:226344
decreased platelet aggregation J:226344
decreased platelet alpha-granule number J:226344
decreased susceptibility to induced thrombosis J:226344
normal homeostasis/metabolism phenotype J:226344
increased hematocrit J:226344
Pik3c2atm1Bvan/Pik3c2atm1Bvan
involves: C57BL/6 		prenatal lethality, complete penetrance J:226344
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory