Nkx6-1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Nkx6-1
NK6 homeobox 1
MGI:1206039

16 phenotypes from 3 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Nkx6-1^tm1Jlr/Nkx6-1^tm1.2Msan involves: 129S6/SvEvTac * C57BL * DBA * SJL	decreased pancreatic beta cell number	J:195153
	forelimb paralysis	J:195153
	neonatal lethality, complete penetrance	J:195153
Nkx6-1^tm1Jlr/Nkx6-1^tm1Jlr involves: 129	abnormal motor capabilities/coordination/movement	J:64376
	abnormal neuron specification	J:64376
	abnormal ventral interneuron 1 morphology	J:64376
	abnormal ventral interneuron 2 morphology	J:64376
	decreased motor neuron number	J:64376
	neonatal lethality, complete penetrance	J:64376
Nkx6-1^tm1Jlr/Nkx6-1^tm1Jlr involves: 129 * C57BL/6J	decreased insulin secretion	J:65594
	decreased pancreatic beta cell number	J:65594
	small pancreatic islets	J:65594
Tg(CAG-Bgeo,-Nkx6-1,-EGFP)#Msan/0 Tg(Gcg-cre)1Herr/0 involves: BALB/c * C57BL/6 * C57BL/6J * CBA/J	normal endocrine/exocrine gland phenotype	J:195153
Tg(CAG-Bgeo,-Nkx6-1,-EGFP)#Msan/0 Tg(Neurog3-cre)C1Able/0 involves: BALB/c * C57BL/6	decreased pancreatic alpha cell number	J:195153
	decreased pancreatic delta cell number	J:195153
	decreased pancreatic epsilon cell number	J:195153
	normal endocrine/exocrine gland phenotype	J:195153
	normal homeostasis/metabolism phenotype	J:195153
	increased pancreatic beta cell number	J:195153

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24