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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Nkx6-1
NK6 homeobox 1
MGI:1206039
13 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Nkx2-2tm1Jlr/Nkx2-2tm1Jlr
Nkx6-1tm1Jlr/Nkx6-1tm1Jlr
involves: 129 * 129X1/SvJ * C57BL/6J 		decreased pancreatic alpha cell number J:65594
decreased pancreatic beta cell number J:65594
decreased PP cell number J:65594
disorganized pancreatic islets J:65594
Nkx6-1tm1.1Msan/Nkx6-1+
Pdx1tm1Cvw/Pdx1+
Tg(Neurog3-cre)C1Able/0
involves: 129/Sv * C57BL/6 * SJL 		abnormal pancreatic islet morphology J:195153
decreased pancreatic beta cell number J:195153
increased pancreatic alpha cell number J:195153
Nkx6-1tm1Jlr/Nkx6-1tm1.1Msan
Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Tg(Ins2-cre)25Mgn/0
involves: 129 * C57BL/6 * DBA * SJL 		abnormal pancreatic beta cell differentiation J:195153
decreased pancreatic beta cell number J:195153
increased pancreatic delta cell number J:195153
Nkx6-1tm1Jlr/Nkx6-1tm1.1Msan
Tg(CAG-Bgeo/GFP)21Lbe/0
Tg(Neurog3-cre)C1Able/0
involves: 129/Sv * C57BL/6 * SJL 		abnormal pancreatic beta cell differentiation J:195153
decreased pancreatic beta cell number J:195153
dehydration J:195153
normal endocrine/exocrine gland phenotype J:195153
hyperglycemia J:195153
increased pancreatic alpha cell number J:195153
increased pancreatic delta cell number J:195153
increased pancreatic epsilon cell number J:195153
postnatal lethality, complete penetrance J:195153
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory