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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Pik3ca
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
MGI:1206581
111 phenotypes from 15 alleles in 20 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Egr2tm2(cre)Pch/Egr2+
Gt(ROSA)26Sortm7(Pik3ca*,EGFP)Rsky/?
involves: 129S2/SvPas * C57BL/6 		abnormal myelination J:207470
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
involves: 129S6/SvEvTac 		abnormal blood vessel morphology J:170898
premature death J:170898
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
involves: 129S6/SvEvTac * CD-1 		abnormal ovary morphology J:219794
normal neoplasm J:219794
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
Tg(MMTV-cre)1Mam/0
involves: 129S6/SvEvTac * FVB/N 		increased mammary gland tumor incidence J:170898
increased tumor incidence J:170898
premature death J:170898
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
Olig2tm1.1(cre)Wdr/Olig2+
involves: 129 * C57BL/6 * FVB/N 		normal neoplasm J:285841
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
Tg(MMTV-cre)#Tfln/0
involves: 129S6/SvEvTac 		increased mammary adenocarcinoma incidence J:170898
increased mammary gland tumor incidence J:170898
increased tumor incidence J:170898
premature death J:170898
Gt(ROSA)26Sortm2(Pik3ca)Egan/Gt(ROSA)26Sor+
Tg(MMTV-cre)1Mam/0
involves: 129S6/SvEvTac * FVB/N 		no abnormal phenotype detected J:170898
Gt(ROSA)26Sortm2(Pik3ca)Egan/Gt(ROSA)26Sor+
Tg(MMTV-cre)#Tfln/0
involves: 129S6/SvEvTac 		no abnormal phenotype detected J:170898
Gt(ROSA)26Sortm2(Pik3ca*)Dsa/Gt(ROSA)26Sor+
Ptf1atm1(cre)Hnak/Ptf1a+
involves: 129S6/SvEvTac 		enlarged pancreas J:197054
increased carcinoma incidence J:197054
increased pancreas weight J:197054
increased pancreatic ductal adenocarcinoma incidence J:197054
increased pancreatic intraepithelial neoplasia incidence J:197054
pancreatic acinar-to-ductal metaplasia J:197054
Gt(ROSA)26Sortm2(Pik3ca*)Dsa/Gt(ROSA)26Sor+
Tg(Cela1-cre/ERT)1Dam/0
involves: 129S6/SvEvTac 		increased pancreatic intraepithelial neoplasia incidence J:197054
pancreatic acinar-to-ductal metaplasia J:197054
Gt(ROSA)26Sortm7(Pik3ca*,EGFP)Rsky/Gt(ROSA)26Sor+
Tg(CAG-cre/Esr1*)5Amc/0
B6.Cg-Gt(ROSA)26Sortm7(Pik3ca*,EGFP)Rsky Tg(CAG-cre/Esr1*)5Amc 		abnormal blood vessel morphology J:264410
abnormal limb morphology J:264410
abnormal spleen morphology J:264410
abnormal vein morphology J:264410
dilated vasculature J:264410
enlarged lymphatic vessel J:264410
hepatic steatosis J:264410
increased cell proliferation J:264410
increased classified tumor incidence J:264410
internal hemorrhage J:264410
kidney cyst J:264410
liver hemorrhage J:264410
postnatal lethality, incomplete penetrance J:264410
premature death J:264410
renal fibrosis J:264410
scoliosis J:264410
skeletal muscle hypertrophy J:264410
visceromegaly J:264410
Gt(ROSA)26Sortm7(Pik3ca*,EGFP)Rsky/Gt(ROSA)26Sortm7(Pik3ca*,EGFP)Rsky
Tg(Cr2-cre)3Cgn/0
involves: C57BL/6 		neonatal lethality, complete penetrance J:157297
Pik3catm1.1Jjz/Pik3catm1.1Jjz
involves: C57BL/6 		abnormal cell physiology J:115274
Pik3catm1.1Rzl/Pik3catm1.1Rzl
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
involves: 129S4/SvJaeSor * C57BL/6 * FVB/N 		abnormal myocardial fiber physiology J:166421
decreased cardiac muscle contractility J:166421
decreased heart weight J:166421
increased heart left ventricle size J:166421
thick ventricular wall J:166421
Pik3catm1.1Rzl/Pik3catm1.1Rzl
Tg(Fabp4-cre)1Blw/0
involves: 129 * C57BL/6 * FVB/N 		abnormal anogenital distance J:315599
abnormal circulating androgen level J:315599
abnormal hormone level J:315599
abnormal testis physiology J:315599
abnormal white adipose tissue physiology J:315599
decreased circulating luteinizing hormone level J:315599
decreased testis weight J:315599
delayed balanopreputial separation J:315599
delayed sexual maturation J:315599
normal homeostasis/metabolism phenotype J:315599
increased body weight J:315599
increased circulating leptin level J:315599
increased circulating testosterone level J:315599
increased total body fat amount J:315599
male infertility J:315599
normal reproductive system phenotype J:315599
Pik3catm1.1Waph/Pik3ca+
involves: 129S1/Sv * C57BL/6 		abnormal ovary morphology J:184382
decreased fibroblast apoptosis J:184382
increased fibroblast proliferation J:184382
Pik3catm1.1Waph/Pik3ca+
Tg(MMTV-cre)#Mam/0
involves: 129S1/Sv * C57BL/6 * FVB 		abnormal branching of the mammary ductal tree J:187299
abnormal mammary duct terminal end bud morphology J:187299
abnormal mammary gland duct morphology J:187299
abnormal mammary gland epithelium morphology J:187299
abnormal mammary gland myoepithelium morphology J:187299
abnormal mammary gland stroma morphology J:187299
increased fibroadenoma incidence J:187299
increased mammary adenoacanthoma incidence J:187299
increased mammary gland epithelial cell proliferation J:187299
increased mammary gland tumor incidence J:187299
increased osteosarcoma incidence J:187299
increased sarcoma incidence J:187299
premature death J:187299
Pik3catm1Bvan/Pik3ca+
involves: 129P2/OlaHsd 		abnormal angiogenesis J:136236
abnormal retina vasculature morphology J:136236
Pik3catm1Bvan/Pik3ca+
involves: 129P2/OlaHsd * C57BL/6 		decreased body length J:109024
decreased body weight J:109024
decreased lean body mass J:109024
decreased skeletal muscle mass J:109024
fetal growth retardation J:109024
impaired glucose tolerance J:109024
increased circulating insulin level J:109024
increased circulating leptin level J:109024
increased fat cell size J:109024
increased pancreatic beta cell number J:109024
insulin resistance J:109024
polyphagia J:109024
postnatal growth retardation J:109024
Pik3catm1Bvan/Pik3catm1Bvan
involves: 129P2/OlaHsd 		abnormal dorsal aorta morphology J:136236
abnormal intersomitic vessel morphology J:136236
abnormal perineural vascular plexus morphology J:136236
abnormal vascular development J:136236
abnormal vitelline vascular remodeling J:136236
embryonic growth arrest J:136236
embryonic growth retardation J:136236
embryonic lethality, complete penetrance J:136236
internal hemorrhage J:136236
Pik3catm1Bvan/Pik3catm1Bvan
involves: 129P2/OlaHsd * C57BL/6 		embryonic growth retardation J:109024
embryonic lethality during organogenesis, complete penetrance J:109024
Pik3catm1Gilb/Pik3ca+
Not Specified 		normal neoplasm J:186709
Pik3catm1Gne/Pik3ca+
Tg(MMTV-cre)1Mam/0
involves: C57BL/6N * FVB/N 		abnormal branching of the mammary ductal tree J:193377
increased mammary gland tumor incidence J:193377
normal neoplasm J:193377
Pik3catm1Gne/Pik3catm1Gne
involves: C57BL/6N 		normal mortality/aging J:193377
Pik3catm1Jdo/Pik3catm1Jdo
B6.129S7(Cg)-Pik3catm1Jdo 		abnormal lymphangiogenesis J:122866
abnormal lymphatic vessel morphology J:122866
chylous ascites J:122866
decreased body weight J:122866
decreased incidence of tumors by chemical induction J:122866
neonatal lethality, incomplete penetrance J:122866
postnatal lethality, incomplete penetrance J:122866
Pik3catm1Jjz/Pik3catm1Jjz
Tg(OPN1LW-cre)4Yzl/0
involves: 129 * FVB/N 		decreased b-wave amplitude J:282245
retina cone cell degeneration J:282245
Pik3catm1Jjz/Pik3catm1Jjz
Tg(Pbsn-cre)4Prb/0
involves: 129 * C57BL/6 * DBA/2 		abnormal cell physiology J:138565
increased prostate intraepithelial neoplasia incidence J:138565
Pik3catm1Nbm/Pik3catm1Nbm
involves: 129S6/SvEvTac 		abnormal somite development J:54237
decreased cell proliferation J:54237
decreased embryo size J:54237
embryonic lethality during organogenesis, complete penetrance J:54237
hemorrhage J:54237
Pik3catm1Nbm/Pik3catm1Nbm
involves: 129S6/SvEvTac * CD-1 		abnormal anterior cardinal vein morphology J:98972
abnormal brain vasculature morphology J:98972
abnormal endocardium morphology J:98972
abnormal vitelline vasculature morphology J:98972
blood vessel congestion J:98972
embryonic lethality during organogenesis, complete penetrance J:98972
pale yolk sac J:98972
Pik3catm3Bvan/Pik3catm3Bvan
Tg(Tek-cre)1Ywa/0
involves: 129P2/OlaHsd * C57BL/6 * SJL 		abnormal vascular development J:136236
abnormal vitelline vascular remodeling J:136236
embryonic lethality during organogenesis, complete penetrance J:136236
Tg(Amhr2-Pik3ca*,-GFP)#Lzh/0
involves: C3H * C57BL/6 		abnormal ovarian follicle number J:144834
abnormal ovary morphology J:144834
normal neoplasm J:144834
reduced female fertility J:144834
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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07/02/2024
MGI 6.13 		The Jackson Laboratory