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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Sgpl1
sphingosine phosphate lyase 1
MGI:1261415
104 phenotypes from 6 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Actbtm4(cre/ERT2)Npa/Actb+
Sgpl1tm1.1Npa/Sgpl1tm1.1Npa
involves: BALB/cJ * C57BL/6 		abnormal lipid homeostasis J:199525
abnormal lymph node morphology J:199525
abnormal regulatory T cell number J:199525
abnormal type IV hypersensitivity reaction J:199525
decreased follicular B cell number J:199525
decreased marginal zone B cell number J:199525
decreased single-positive T cell number J:199525
decreased susceptibility to experimental autoimmune encephalomyelitis J:199525
normal growth/size/body region phenotype J:199525
increased thymocyte number J:199525
normal mortality/aging J:199525
spleen hypoplasia J:199525
Sgpl1Gt(OST58278)Lex/Sgpl1Gt(OST58278)Lex
involves: 129S5/SvEvBrd * C57BL/6J 		abnormal bone marrow morphology J:145159
abnormal definitive hematopoiesis J:145159
abnormal heart morphology J:145159
abnormal lymph node morphology J:145159
abnormal lymphopoiesis J:145159
abnormal myocardial fiber morphology J:145159
abnormal osteoclast morphology J:145159
abnormal pulmonary alveolus morphology J:145159
abnormal small intestine morphology J:145159
abnormal spleen periarteriolar lymphoid sheath morphology J:145159
abnormal trabecular bone morphology J:145159
abnormal urothelium morphology J:145159
decreased B cell number J:145159
decreased body weight J:145159
decreased double-positive T cell number J:145159
decreased lymphocyte cell number J:145159
decreased neutrophil cell number J:145159
decreased pre-B cell number J:145159
decreased T cell number J:145159
increased CD4-positive, alpha-beta T cell number J:145159
increased CD8-positive, alpha-beta T cell number J:145159
increased granulocyte number J:145159
increased monocyte cell number J:145159
increased osteoclast cell number J:145159
lymph node hypoplasia J:145159
lymphoid hypoplasia J:145159
postnatal growth retardation J:145159
premature death J:145159
spleen hypoplasia J:145159
thick pulmonary interalveolar septum J:145159
thymus cortex hypoplasia J:145159
thymus hypoplasia J:145159
thymus medulla hyperplasia J:145159
Sgpl1Gt(ROSA)78Sor/Sgpl1Gt(ROSA)78Sor
either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6) 		abnormal ovary morphology J:142042
abnormal spermatid morphology J:142042
abnormal spermatocyte morphology J:142042
abnormal spermatogenesis J:142042
abnormal testis cord formation J:142042
abnormal testis morphology J:142042
abnormal testosterone level J:142042
abnormal vascular smooth muscle morphology J:142042
absent corpus luteum J:142042
anovulation J:142042
decreased circulating estradiol level J:142042
decreased circulating testosterone level J:142042
decreased Leydig cell number J:142042
decreased tertiary ovarian follicle number J:142042
decreased theca cell number J:142042
female infertility J:142042
male infertility J:142042
multinucleated giant male germ cells J:142042
small ovary J:142042
small testis J:142042
uterus hypoplasia J:142042
Sgpl1Gt(ROSA)78Sor/Sgpl1Gt(ROSA)78Sor
involves: 129S4/SvJaeSor 		abnormal blood vessel morphology J:117491
abnormal cell migration J:117491
abnormal frontal bone morphology J:117491
abnormal kidney morphology J:117491
abnormal kidney physiology J:117491
abnormal neurocranium morphology J:117491
abnormal palatal shelf fusion at midline J:117491
abnormal renal glomerulus morphology J:117491
abnormal skeleton morphology J:117491
abnormal smooth muscle morphology J:117491
abnormal sternum morphology J:117491
abnormal vertebrae morphology J:117491
abnormal vertebral arch morphology J:117491
absent podocyte slit diaphragm J:242932
anemia J:117491
asymmetric sternocostal joints J:117491
decreased body weight J:117491
decreased circulating serum albumin level J:242932
decreased erythrocyte cell number J:117491
decreased fibroblast cell migration J:117491
decreased hematocrit J:117491
decreased hemoglobin content J:117491
decreased palatine bone horizontal plate size J:117491
hemorrhage J:117491
increased blood urea nitrogen level J:117491
kidney inflammation J:117491
pale kidney J:117491
podocyte foot process effacement J:242932
polychromatophilia J:117491
postnatal growth retardation J:117491
premature death J:117491
reticulocytosis J:117491
small kidney J:117491
small presphenoid bone J:117491
Sgpl1Gt(ROSA)78Sor/Sgpl1Gt(ROSA)78Sor
involves: 129S4/SvJaeSor * C57BL/6 		abnormal immune system physiology J:187619
abnormal leukocyte migration J:187619
abnormal T cell physiology J:187619
decreased lymphocyte cell number J:187619
Sgpl1tm1.1(KOMP)Vlcg/Sgpl1+
C57BL/6N-Sgpl1tm1.1(KOMP)Vlcg/Ucd 		abnormal epididymis morphology J:211773
abnormal testis morphology J:211773
enlarged epididymis J:211773
small testis J:211773
Sgpl1tm1.1(KOMP)Vlcg/Sgpl1tm1.1(KOMP)Vlcg
C57BL/6N-Sgpl1tm1.1(KOMP)Vlcg/Ucd 		preweaning lethality, complete penetrance J:211773
Sgpl1tm1.2Npa/Sgpl1tm1.2Npa
involves: BALB/cJ * C57BL/6 		abnormal lipid homeostasis J:199525
abnormal postnatal growth J:199525
postnatal lethality J:199525
spleen hypoplasia J:199525
Sgpl1tm1a(KOMP)Saba/Sgpl1+
B6.129P2-Sgpl1tm1a(KOMP)Saba 		no abnormal phenotype detected J:187619
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
07/02/2024
MGI 6.13 		The Jackson Laboratory