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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Sgpl1
sphingosine phosphate lyase 1
MGI:1261415
18 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Pdgfratm1Sor/Pdgfra+
Sgpl1Gt(ROSA)78Sor/Sgpl1Gt(ROSA)78Sor
either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6) 		female infertility J:142042
male infertility J:142042
Pdgfrbtm1Sor/Pdgfrb+
Sgpl1Gt(ROSA)78Sor/Sgpl1Gt(ROSA)78Sor
either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6) 		female infertility J:142042
male infertility J:142042
Sgpl1Gt(OST58278)Lex/Sgpl1tm1(SGPL1)Lex
involves: 129S5/SvEvBrd * C57BL/6J 		abnormal immune system organ morphology J:145159
abnormal osteoclast morphology J:145159
abnormal urinary bladder urothelium morphology J:145159
normal cardiovascular system phenotype J:145159
decreased T cell number J:145159
normal respiratory system phenotype J:145159
thymus cortex hypoplasia J:145159
thymus medulla hyperplasia J:145159
Sgpl1tm1(SGPL1)Lex/Sgpl1tm1(SGPL1)Lex
involves: 129S4/SvJae * 129S5/SvEvBrd * C57BL/6J 		abnormal immune system organ morphology J:145159
abnormal lymph node morphology J:145159
abnormal renal/urinary system morphology J:145159
abnormal thymus lobule morphology J:145159
decreased B cell number J:145159
decreased CD4-positive, alpha-beta T cell number J:145159
decreased CD8-positive, alpha-beta T cell number J:145159
decreased lymphocyte cell number J:145159
decreased T cell number J:145159
increased single-positive T cell number J:145159
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory