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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Casp8
caspase 8
MGI:1261423
105 phenotypes from 14 alleles in 14 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Casp8em1(IMPC)Ccpcz/Casp8+
C57BL/6NCrl-Casp8em1(IMPC)Ccpcz/Ccpcz 		abnormal heart morphology J:211773
abnormal kidney morphology J:211773
abnormal liver morphology J:211773
decreased lymphocyte cell number J:211773
enlarged heart J:211773
increased heart left ventricle size J:211773
small kidney J:211773
small liver J:211773
thick ventricular wall J:211773
Casp8em1(IMPC)Ccpcz/Casp8em1(IMPC)Ccpcz
C57BL/6NCrl-Casp8em1(IMPC)Ccpcz/Ccpcz 		embryonic lethality prior to tooth bud stage J:211773
preweaning lethality, incomplete penetrance J:211773
Casp8em1Hbz/Casp8em1Hbz
involves: C57BL/6 		decreased apoptosis J:342732
decreased CD8-positive, alpha-beta T cell number J:342732
decreased circulating alanine transaminase level J:342732
decreased circulating aspartate transaminase level J:342732
enlarged spleen J:342732
normal hematopoietic system phenotype J:342732
normal mortality/aging J:342732
Casp8kuche/Casp8kuche
involves: C57BL/6JAnu * C57BL/10SnJ 		impaired hematopoiesis J:104190
small liver J:104190
Casp8m1Btlr/Casp8m1Btlr
C57BL/6J-Casp8m1Btlr 		decreased CD4-positive, alpha-beta T cell number J:255007
decreased CD8-positive, naive alpha-beta T cell number J:255007
decreased T cell number J:255007
increased CD8-positive, alpha-beta T cell number J:255007
increased effector memory CD4-positive, alpha-beta T cell number J:255007
Casp8M2Btlr/Casp8M2Btlr
C57BL/6J-Casp8M2Btlr 		increased effector memory CD8-positive, alpha-beta T cell number J:272851
Casp8tm1.1Raz/Casp8tm1.1Raz
involves: 129P2/OlaHsd 		abnormal blood circulation J:170815
abnormal vitelline vasculature morphology J:170815
embryonic lethality, complete penetrance J:82759, J:170815
wavy neural tube J:170815
Casp8tm1.1Vmd/Casp8tm1.1Vmd
involves: C57BL/6N 		embryonic lethality, complete penetrance J:209137
Casp8tm1.1Yuan/Casp8tm1.1Yuan
involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * MF1 		abnormal blood circulation J:49459
abnormal hematopoietic system morphology/development J:49459
abnormal myocardium layer morphology J:49459
decreased embryo size J:49459
prenatal lethality, complete penetrance J:49459
Casp8tm1Clie/Casp8tm1Clie
Tg(Alb1-cre)7Gsc/0
involves: 129P2/OlaHsd * C57BL/6 * FVB/N 		abnormal circulating enzyme level J:218665
decreased susceptibility to injury J:218665
increased susceptibility to injury J:218665
liver inflammation J:218665
Casp8tm1Hed/Casp8tm1Hed
Cd19tm1(cre)Cgn/Cd19+
involves: 129P2/OlaHsd 		abnormal adaptive immunity J:116713
abnormal immunoglobulin level J:116713
decreased B cell number J:116713
decreased B cell proliferation J:116713
decreased B-1 B cell number J:116713
decreased marginal zone B cell number J:116713
increased apoptosis J:116713
spleen hypoplasia J:116713
Casp8tm1Hed/Casp8tm1Hed
Tg(KRT14-cre)1Efu/0
Not Specified 		abnormal epidermal layer morphology J:167299
abnormal keratinocyte morphology J:167299
abnormal skin morphology J:167299
abnormal skin vasculature morphology J:167299
abnormal T cell physiology J:167299
acanthosis J:167299
dermatitis J:167299
dry skin J:167299
epidermal hyperplasia J:167299
epidermal spongiosis J:167299
impaired skin barrier function J:167299
increased IgE level J:167299
increased IgG1 level J:167299
increased mast cell number J:167299
postnatal lethality, incomplete penetrance J:167299
premature death J:167299
scaly skin J:167299
skin edema J:167299
thick epidermis J:167299
Casp8tm1Raz/Casp8tm1Raz
Tg(Lck-cre)548Jxm/0
involves: 129P2/OlaHsd * C57BL/6 * CBA 		abnormal CD8-positive, alpha-beta T cell physiology J:82759
abnormal kidney morphology J:107455
abnormal liver morphology J:107455
abnormal lung morphology J:107455
abnormal lymphocyte morphology J:107455
abnormal T cell activation J:107455
abnormal T cell morphology J:82759
abnormal T cell physiology J:107455
abnormal T cell proliferation J:107455
abnormal T cell subpopulation ratio J:82759, J:107455
decreased body size J:107455
decreased body weight J:107455
decreased CD4-positive, alpha-beta T cell number J:82759
decreased CD8-positive, alpha-beta T cell number J:82759
decreased leukocyte cell number J:107455
decreased T cell apoptosis J:82759
decreased T cell number J:82759
decreased T cell proliferation J:82759
enlarged lymph nodes J:107455
enlarged spleen J:107455
increased B cell number J:107455
increased lymphocyte cell number J:107455
increased T cell number J:107455
lymphoid hyperplasia J:107455
premature death J:107455
Casp8tm1Syon/Casp8tm1Syon
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal embryonic hematopoiesis J:103506
abnormal heart morphology J:103506
abnormal vitelline vascular remodeling J:103506
embryonic lethality during organogenesis, complete penetrance J:103506
hemopericardium J:103506
increased cardiomyocyte apoptosis J:103506
kinked neural tube J:103506
pale yolk sac J:103506
Casp8tm1Wll/Casp8tm1.1Yuan
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129S1/Sv * 129X1/SvJ * MF1 		abnormal macrophage differentiation J:92722
Casp8tm1Wll/Casp8tm1.1Yuan
Tg(Alb1-cre)7Gsc/0
involves: 129S1/Sv * 129X1/SvJ * MF1 		abnormal response/metabolism to endogenous compounds J:92722
decreased susceptibility to induced morbidity/mortality J:92722
Casp8tm1Wll/Casp8tm1.1Yuan
Tg(Mx1-cre)1Cgn/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * MF1 		abnormal myeloblast morphology/development J:92722
decreased susceptibility to induced morbidity/mortality J:92722
Casp8tm1Wll/Casp8tm1.1Yuan
Tg(Tie1-cre)9Ref/0
involves: 129S1/Sv * 129X1/SvJ * MF1 		abnormal visceral yolk sac morphology J:92722
abnormal vitelline vasculature morphology J:92722
embryonic lethality during organogenesis, complete penetrance J:92722
globular heart J:92722
normal hematopoietic system phenotype J:92722
myocardium necrosis J:92722
pericardial edema J:92722
thin ventricular wall J:92722
visceral vascular congestion J:92722
wavy neural tube J:92722
Casp8tm1Yuan/Casp8tm1Yuan
involves: 129S1/Sv * 129X1/SvJ * MF1 		abnormal blood cell morphology/development J:49459
abnormal blood circulation J:49459
abnormal cell death J:49459
abnormal heart ventricle morphology J:49459
abnormal myocardial trabeculae morphology J:49459
abnormal myocardium layer morphology J:49459
decreased embryo size J:49459
embryonic lethality during organogenesis, incomplete penetrance J:49459
embryonic lethality, complete penetrance J:49459
increased erythrocyte cell number J:49459
thin myocardium J:49459
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory