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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Casp8
caspase 8
MGI:1261423
62 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Casp8em1Hbz/Casp8em1Hbz
Mlklem1Hbz/Mlklem1Hbz
involves: C57BL/6 		decreased B cell number J:342732
decreased leukocyte cell number J:342732
decreased lymphocyte cell number J:342732
decreased mature B cell number J:342732
decreased T cell number J:342732
enlarged spleen J:342732
increased CD11b-high dendritic cell number J:342732
increased granulocyte number J:342732
increased macrophage cell number J:342732
Casp8em1Hbz/Casp8em1Hbz
Ripk1em1Hbz/Ripk1em1Hbz
Ripk3tm1Xidw/Ripk3tm1Xidw
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		decreased leukocyte cell number J:342732
decreased lymphocyte cell number J:342732
decreased mature B cell number J:342732
decreased T cell number J:342732
Casp8em1Hbz/Casp8em1Hbz
Ripk1em4Hbz/Ripk1em4Hbz
Ripk3tm1Xidw/Ripk3tm1Xidw
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		decreased body size J:342732
preweaning lethality, complete penetrance J:342732
scaly skin J:342732
skin lesions J:342732
Casp8em1Hbz/Casp8em1Hbz
Ripk3tm1Xidw/Ripk3tm1Xidw
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		decreased B cell number J:342732
decreased leukocyte cell number J:342732
decreased lymphocyte cell number J:342732
decreased mature B cell number J:342732
decreased T cell number J:342732
enlarged spleen J:342732
increased CD11b-high dendritic cell number J:342732
increased granulocyte number J:342732
increased macrophage cell number J:342732
Casp8tm1.1Raz/Casp8tm1.1Raz
Otulinem1Gvl/Otulinem1Gvl
Ripk3tm1Vmd/Ripk3tm1Vmd
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J 		normal embryo phenotype J:312394
enlarged lymph nodes J:312394
normal immune system phenotype J:312394
normal integument phenotype J:312394
Casp8tm1.1Raz/Casp8tm1.1Raz
Ripk3tm1Vmd/Ripk3+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ 		abnormal visceral yolk sac blood island morphology J:170815
abnormal vitelline vasculature morphology J:170815
embryonic growth arrest J:170815
embryonic lethality, complete penetrance J:170815
Casp8tm1.1Raz/Casp8tm1.1Raz
Ripk3tm1Vmd/Ripk3tm1Vmd
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ 		abnormal liver physiology J:170815
abnormal macrophage physiology J:170815
decreased hepatocyte apoptosis J:170814
decreased macrophage apoptosis J:170815
decreased thymocyte apoptosis J:170814
enlarged axillary lymph nodes J:170815
enlarged cervical lymph nodes J:170815
enlarged lymph nodes J:170814
enlarged spleen J:170814, J:170815
enlarged thymus J:170814
normal growth/size/body region phenotype J:170814
normal hematopoietic system phenotype J:170814, J:170815
normal immune system phenotype J:170815
increased B cell number J:170815
increased inflammatory response J:170815
increased leukocyte cell number J:170815
increased spleen white pulp amount J:170815
increased T cell number J:170814, J:170815
large lymphoid organs J:170814
lymph node hyperplasia J:170815
normal mortality/aging J:170814, J:170815
Casp8tm1.1Vmd/Casp8+
Ripk3tm2Vmd/Ripk3tm2Vmd
involves: C57BL/6N 		lethality throughout fetal growth and development, complete penetrance J:209137
Casp8tm1.1Vmd/Casp8tm1.1Vmd
Ripk3tm2Vmd/Ripk3tm2Vmd
involves: C57BL/6N 		enlarged lymph nodes J:209137
enlarged spleen J:209137
increased T cell number J:209137
normal mortality/aging J:209137
Casp8tm1Clie/Casp8tm1Clie
Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr
Tg(Alb1-cre)7Gsc/0
involves: 129P2/OlaHsd * C57BL/6 * FVB/N 		abnormal biliary tract morphology J:218665
abnormal circulating enzyme level J:218665
abnormal liver morphology J:218665
decreased body size J:218665
enlarged liver J:218665
hepatic necrosis J:218665
increased bile salt level J:218665
increased circulating alkaline phosphatase level J:218665
increased circulating bilirubin level J:218665
intrahepatic cholestasis J:218665
liver fibrosis J:218665
normal neoplasm J:218665
Casp8tm1Clie/Casp8tm1Clie
Map3k7tm1Aki/Map3k7tm1Aki
Tg(Alb1-cre)7Gsc/0
involves: 129P2/OlaHsd * FVB/N 		abnormal bile duct morphology J:160521
abnormal liver morphology J:160521
bile duct proliferation J:160521
focal hepatic necrosis J:160521
increased circulating alanine transaminase level J:160521
increased circulating aspartate transaminase level J:160521
increased circulating bilirubin level J:160521
normal mortality/aging J:160521
postnatal growth retardation J:160521
Casp8tm1Syon/Casp8tm1Syon
Tg(Myh7-BVp35-EGFP)#Ksa/?
involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 		abnormal neural tube morphology J:102279
abnormal vitelline vasculature morphology J:102279
normal cardiovascular system phenotype J:102279
embryonic lethality during organogenesis, complete penetrance J:102279
hemopericardium J:102279
increased cardiomyocyte apoptosis J:102279
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory