Drosha Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Drosha
drosha, ribonuclease type III
MGI:1261425

68 phenotypes from 6 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Drosha^tm1.1Vlcg/Drosha^tm1.1Vlcg involves: 129S6/SvEvTac * C57BL/6NTac	no abnormal phenotype detected	J:200671
Drosha^tm1.1Vlcg/Drosha^tm3Vlcg Gt(ROSA)26Sor^{tm3.1(cre/ERT2)Vlcg}/Gt(ROSA)26Sor⁺ involves: 129S6/SvEvTac * C57BL/6NTac	decreased body size	J:200671
	normal mortality/aging	J:200671
Drosha^tm1Ghan/Drosha^tm1Ghan Tg(KRT5-rtTA)1Glk/0 Tg(tetO-cre)1Jaw/0 involves: 129 * C57BL/6 * FVB/N	abnormal hair follicle bulge morphology	J:183487
	decreased body size	J:183487
Drosha^tm1Litt/Drosha^tm1.1Litt Foxp3^{tm4(YFP/icre)Ayr}/Y involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N	abnormal interferon-gamma secretion	J:138683
	abnormal interleukin-4 secretion	J:138683
	abnormal T cell activation	J:138683
	blood vessel inflammation	J:138683
	enlarged lymph nodes	J:138683
	enlarged spleen	J:138683
	increased CD8-positive, alpha-beta T cell number	J:138683
	increased leukocyte cell number	J:138683
	liver inflammation	J:138683
	lung inflammation	J:138683
	premature death	J:138683
Drosha^tm1Litt/Drosha^tm1.1Litt Foxp3^{tm4(YFP/icre)Ayr}/Foxp3^{tm4(YFP/icre)Ayr} involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N	abnormal interferon-gamma secretion	J:138683
	abnormal interleukin-4 secretion	J:138683
	abnormal regulatory T cell morphology	J:138683
	abnormal T cell activation	J:138683
	blood vessel inflammation	J:138683
	enlarged lymph nodes	J:138683
	enlarged spleen	J:138683
	increased CD8-positive, alpha-beta T cell number	J:138683
	increased leukocyte cell number	J:138683
	liver inflammation	J:138683
	lung inflammation	J:138683
	premature death	J:138683
Drosha^tm1Litt/Drosha^tm1.1Litt Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor⁺ involves: 129 * 129P2/OlaHsd * C57BL/6 * FVB/N	abnormal interferon-gamma secretion	J:138683
Drosha^tm1Litt/Drosha^tm1.1Litt Tg(Cd4-cre)1Cwi/0 involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N	abnormal immune system physiology	J:138683
	cachexia	J:138683
	decreased body fat mass	J:138683
	decreased CD8-positive, alpha-beta T cell number	J:138683
	decreased double-positive T cell number	J:138683
	decreased lymphocyte cell number	J:138683
	decreased regulatory T cell number	J:138683
	decreased skeletal muscle mass	J:138683
	decreased thymocyte number	J:138683
	normal immune system phenotype	J:138683
	increased activated T cell number	J:138683
	increased gamma-delta T cell number	J:138683
	increased granulocyte number	J:138683
	intestinal inflammation	J:138683
	liver inflammation	J:138683
	lung inflammation	J:138683
	premature death	J:138683
Drosha^tm1Litt/Drosha^tm1Litt Tg(KRT5-rtTA)1Glk/0 Tg(tetO-cre)1Jaw/0 involves: 129P2/OlaHsd * C57BL/6 * FVB/N	abnormal coat/ hair morphology	J:183487
	abnormal hair cycle catagen phase	J:183487
	abnormal hair follicle inner root sheath morphology	J:183487
	abnormal hair follicle morphology	J:183487
	abnormal hair follicle regression	J:183487
	abnormal hair growth	J:183487
	abnormal hair shaft morphology	J:183487
	abnormal skin physiology	J:183487
	alopecia	J:183487
	decreased body size	J:183487
	dry skin	J:183487
	epidermal hyperplasia	J:183487
	hair follicle degeneration	J:183487
	increased apoptosis	J:183487
	normal integument phenotype	J:183487
	scaly skin	J:183487
	small hair follicles	J:183487
	waved hair	J:183487
Drosha^tm1Litt/Drosha^tm1Litt Tg(Six2-EGFP/cre)1Amc/0 involves: 129P2/OlaHsd * CD-1	abnormal kidney development	J:321428
	abnormal kidney morphology	J:321428
	abnormal nephrogenic zone morphology	J:321428
	abnormal renal glomerulus morphology	J:321428
	absent kidney	J:321428
	congestive heart failure	J:321428
	cyanosis	J:321428
	decreased food intake	J:321428
	decreased locomotor activity	J:321428
	decreased renal glomerulus number	J:321428
	dilated renal tubule	J:321428
	increased kidney apoptosis	J:321428
	perinatal lethality, complete penetrance	J:321428
	polycystic kidney	J:321428
	pulmonary edema	J:321428
	renal hypoplasia	J:321428
	respiratory distress	J:321428
Drosha^tm1Litt/Drosha^tm1Litt Wt1^{tm2(cre/ERT2)Wtp}/Wt1⁺ involves: 129P2/OlaHsd * 129S4/SvJae	increased urine protein level	J:321428
	normal mortality/aging	J:321428
	normal neoplasm	J:321428
	normal renal/urinary system phenotype	J:321428
Drosha^tm2.1Vlcg/Drosha^tm2.1Vlcg involves: 129S6/SvEvTac * C57BL/6NTac	no abnormal phenotype detected	J:200671
Drosha^tm2.1Vlcg/Drosha^tm3Vlcg Tg(Nanog-cre)#Vlcg/0 involves: 129S6/SvEvTac * C57BL/6NTac	embryonic lethality, complete penetrance	J:200671
Drosha^tm3Vlcg/Drosha^tm3Vlcg involves: 129S6/SvEvTac * C57BL/6NTac	embryonic lethality, complete penetrance	J:200671

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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