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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Suz12
SUZ12 polycomb repressive complex 2 subunit
MGI:1261758
38 phenotypes from 4 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Suz12Gt(Betageo)1Khe/Suz12+
involves: 129P2/OlaHsd 		increased histiocytic sarcoma incidence J:217077
Suz12Gt(Betageo)1Khe/Suz12Gt(Betageo)1Khe
involves: 129P2/OlaHsd * C57BL/6 		abnormal amnion morphology J:93307
abnormal amniotic cavity morphology J:93307
abnormal chorion morphology J:93307
abnormal developmental patterning J:93307
abnormal ectoplacental cavity morphology J:93307
abnormal embryonic neuroepithelium morphology J:93307
abnormal extraembryonic coelom morphology J:93307
abnormal extraembryonic tissue morphology J:93307
decreased cell proliferation J:93307
decreased embryo size J:93307
embryonic growth arrest J:93307
embryonic lethality, complete penetrance J:93307
increased embryonic tissue cell apoptosis J:93307
Suz12Gt(Betageo)1Khe/Suz12Plt8
involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 		preweaning lethality, complete penetrance J:136262
Suz12Plt8/Suz12+
involves: 129 * C57BL/6 		increased leukocyte cell number J:136262
increased lymphocyte cell number J:136262
thrombocytosis J:136262
Suz12tm1Hko/Suz12+
Not Specified 		cervical vertebral transformation J:170279
lumbar vertebral transformation J:170279
thoracic vertebral transformation J:170279
vertebral transformation J:170279
Suz12tm1Hko/Suz12tm1Hko
Not Specified 		abnormal extraembryonic tissue morphology J:109525
decreased embryo size J:109525
embryonic lethality between somite formation and embryo turning, complete penetrance J:170279
embryonic lethality, complete penetrance J:109525
Suz12tm1Xmir/Suz12+
Not Specified 		abnormal brain morphology J:150128
abnormal cerebellum morphology J:150128
abnormal cerebral cortex morphology J:150128
abnormal hippocampus morphology J:150128
abnormal posture J:150128
abnormal stratification in cerebral cortex J:150128
decreased corpus callosum size J:150128
diastematomyelia J:150128
enlarged tectum J:150128
hindlimb paralysis J:150128
hydrocephaly J:150128
increased inferior colliculus size J:150128
increased superior colliculus size J:150128
spina bifida J:150128
Suz12tm1Xmir/Suz12tm1Xmir
Not Specified 		embryonic lethality during organogenesis, complete penetrance J:150128
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory