Myo15a Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Myo15a
myosin XVA
MGI:1261811

35 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Cdh23^tm1.1Ugds/Cdh23^tm1.1Ugds Myo15a^{tm1.1(cre)Ugds}/Myo15a⁺ involves: 129S1/SvImJ * C57BL/6J	abnormal cochlear hair bundle tip links morphology	J:171218
	abnormal hearing electrophysiology	J:171218
	abnormal inner hair cell stereociliary bundle morphology	J:171218
	abnormal outer hair cell stereociliary bundle morphology	J:171218
	absent cochlear microphonics	J:171218
	absent distortion product otoacoustic emissions	J:171218
	decreased inner hair cell stereocilia number	J:171218
	decreased outer hair cell stereocilia number	J:171218
	impaired hearing	J:171218
	increased or absent threshold for auditory brainstem response	J:171218
	short inner hair cell stereocilia	J:171218
	short outer hair cell stereocilia	J:171218
Clrn1^tm1.1Ugpa/Clrn1^tm1.1Ugpa Myo15a^{tm1.1(cre)Ugds}/Myo15a⁺ involves: 129S1/SvImJ * C57BL/6N	abnormal cochlear IHC afferent innervation pattern	J:265318
	abnormal cochlear inner hair cell physiology	J:265318
	abnormal cochlear nerve compound action potential	J:265318
	abnormal cochlear nerve fiber response	J:265318
	abnormal cochlear nerve morphology	J:265318
	abnormal inner hair cell stereociliary bundle morphology	J:265318
	abnormal outer hair cell stereociliary bundle morphology	J:265318
	abnormal ribbon synapse morphology	J:265318
	abnormal synapse morphology	J:265318
	abnormal synaptic vesicle exocytosis	J:265318
	cochlear inner hair cell degeneration	J:265318
	cochlear outer hair cell degeneration	J:265318
	deafness	J:265318
	increased or absent distortion product otoacoustic emission threshold	J:265318
	increased or absent threshold for auditory brainstem response	J:265318
	sensorineural hearing loss	J:265318
Myo15a^sh2/Myo15a⁺ Myo6^sv/Myo6⁺ involves: B10.HA/(33NX)Sn	increased susceptibility to age-related hearing loss	J:86379
Myo15a^sh2/Myo15a^sh2 Myo6^sv/Myo6^sv involves: B10.HA/(33NX)Sn	abnormal cochlear hair cell stereociliary bundle morphology	J:86379
	abnormal organ of Corti morphology	J:86379
	decreased body size	J:86379
	short cochlear hair cell stereocilia	J:86379
Myo15a^{tm1.1(cre)Ugds}/Myo15a⁺ Ush1g^tm1.1Ugds/Ush1g^tm1.1Ugds involves: 129S1/SvImJ * C57BL/6J	abnormal cochlear hair bundle tip links morphology	J:171218
	abnormal hair cell mechanoelectric transduction	J:171218
	abnormal hair cell physiology	J:171218
	abnormal hearing electrophysiology	J:171218
	abnormal inner hair cell stereociliary bundle morphology	J:171218
	abnormal outer hair cell stereociliary bundle morphology	J:171218
	abnormal vestibular system physiology	J:171218
	absent cochlear microphonics	J:171218
	absent distortion product otoacoustic emissions	J:171218
	circling	J:171218
	deafness	J:171218
	decreased inner hair cell stereocilia number	J:171218
	decreased outer hair cell stereocilia number	J:171218
	increased or absent threshold for auditory brainstem response	J:171218
	short inner hair cell stereocilia	J:171218
	short outer hair cell stereocilia	J:171218
Pcdh15^tm1.1Ugds/Pcdh15^tm1.1Ugds Myo15a^{tm1.1(cre)Ugds}/Myo15a⁺ involves: 129S1/SvImJ * C57BL/6J	abnormal auditory brainstem response	J:209275
	abnormal cochlear hair bundle tip links morphology	J:209275
	abnormal cochlear nerve compound action potential	J:209275
	abnormal hair cell mechanoelectric transduction	J:209275
	abnormal outer hair cell stereociliary bundle morphology	J:209275
	deafness	J:209275
	decreased inner hair cell stereocilia number	J:209275
	decreased outer hair cell stereocilia number	J:209275
	increased or absent threshold for auditory brainstem response	J:209275
	short inner hair cell stereocilia	J:209275
	short outer hair cell stereocilia	J:209275

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24