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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Dnmt3b
DNA methyltransferase 3B
MGI:1261819
8 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
ApcMin/Apc+
Dnmt3btm1Jae/Dnmt3btm1Jae
Tg(Fabp1-cre)1Jig/0
involves: 129 * C57BL/6 * C57BL/6J * FVB/N 		decreased tumor incidence J:107386
ApcMin/Apc+
Col1a1tm9(tetO-Dnmt3b_i1)Jae/Col1a1+
Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
involves: 129S4/SvJae * C57BL/6 * C57BL/6J 		abnormal DNA methylation J:127808
increased intestinal adenoma incidence J:127808
increased tumor growth/size J:127808
ApcMin/Apc+
Col1a1tm10(tetO-Dnmt3b_i3)Jae/Col1a1+
Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
involves: 129S4/SvJae * C57BL/6 * C57BL/6J 		normal neoplasm J:127808
ApcMin/Apc+
Col1a1tm11(tetO-Dnmt3b_i6)Jae/Col1a1+
Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
involves: 129S4/SvJae * C57BL/6 * C57BL/6J 		normal neoplasm J:127808
Dnmt3atm1Enl/Dnmt3atm1Enl
Dnmt3btm1Enl/Dnmt3btm1Enl
involves: 129S4/SvJae * C57BL/6 		absent somites J:58298
embryonic lethality, complete penetrance J:58298
incomplete embryo turning J:58298
Dnmt3atm2Enl/Dnmt3atm2Enl
Dnmt3btm1Enl/Dnmt3btm1Enl
involves: 129S4/SvJae * C57BL/6 		abnormal DNA methylation J:116773
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory