Dnmt3a Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Dnmt3a
DNA methyltransferase 3A
MGI:1261827

38 phenotypes from 9 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Alpl^tm1(cre)Nagy/Alpl⁺ Dnmt3a^tm3.1Enl/Dnmt3a^tm3.2Enl involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ	azoospermia	J:91108
	decreased testis weight	J:91108
	female infertility	J:91108
	male infertility	J:91108
Dnmt3a^em1Hsas/Dnmt3a⁺ C57BL/6J-Dnmt3a^em1Hsas	abnormal imprinting	J:349016
Dnmt3a^em1Hsas/Dnmt3a⁺ C57BL/6J-Dnmt3a^em1Hsas	prenatal lethality, incomplete penetrance	J:349016
Dnmt3a^em1Hsas/Dnmt3a^em1Hsas C57BL/6J-Dnmt3a^em1Hsas	abnormal DNA methylation during gametogenesis	J:347433, J:349016
	abnormal imprinting	J:347433, J:349016
	abnormal parturition	J:349016
	abnormal pregnancy	J:349016
	prenatal lethality, incomplete penetrance	J:349016
Dnmt3a^tm1.1Jae/Dnmt3a^tm1.1Jae involves: 129S4/SvJae * C57BL/6	decreased body size	J:121563
	postnatal lethality, complete penetrance	J:121563
Dnmt3a^{tm1a(KOMP)Wtsi}/Dnmt3a^{tm1a(KOMP)Wtsi} C57BL/6N-Dnmt3a^{tm1a(KOMP)Wtsi}/Wtsi	increased grip strength	J:211773
Dnmt3a^{tm1b(KOMP)Wtsi}/Dnmt3a⁺ C57BL/6N-Dnmt3a^{tm1b(KOMP)Wtsi}/J	abnormal bone structure	J:211773
	convulsive seizures	J:211773
	decreased circulating cholesterol level	J:211773
	decreased circulating glucose level	J:211773
	decreased circulating HDL cholesterol level	J:211773
	decreased exploration in new environment	J:211773
	decreased lean body mass	J:211773
	increased total body fat amount	J:211773
Dnmt3a^{tm1b(KOMP)Wtsi}/Dnmt3a^{tm1b(KOMP)Wtsi} C57BL/6N-Dnmt3a^{tm1b(KOMP)Wtsi}/J	abnormal embryo size	J:211773
	preweaning lethality, incomplete penetrance	J:211773
Dnmt3a^tm1Enl/Dnmt3a^tm1Enl involves: 129S4/SvJae * C57BL/6	postnatal growth retardation	J:58298
Dnmt3a^tm1Enl/Dnmt3a^tm1Enl involves: 129S4/SvJae * C57BL/6	premature death	J:58298
Dnmt3a^tm1Jae/Dnmt3a^tm1Jae Tg(Nes-cre)1Atp/0 involves: 129S4/SvJae * C57BL/6 * FVB/N	abnormal gait	J:121563
	abnormal neuromuscular synapse morphology	J:121563
	decreased body weight	J:121563
	decreased exploration in new environment	J:121563
	decreased grip strength	J:121563
	decreased locomotor activity	J:121563
	decreased motor neuron number	J:121563
	normal homeostasis/metabolism phenotype	J:121563
	impaired coordination	J:121563
	normal muscle phenotype	J:121563
	normal nervous system phenotype	J:121563
	premature death	J:121563
Dnmt3a^tm1Trow/Dnmt3a⁺ Tg(Mx1-cre)1Cgn/0 B6.Cg-Dnmt3a^tm1Trow Tg(Mx1-cre)1Cgn	abnormal bone marrow hematopoietic cell morphology	J:272803
	abnormal multipotent stem cell morphology	J:272803
	increased common myeloid progenitor cell number	J:272803
	increased hematopoietic stem cell number	J:272803
Dnmt3a^tm3.2Enl/Dnmt3a^tm3.2Enl involves: 129S4/SvJae	postnatal growth retardation	J:91108
Dnmt3a^tm3.2Enl/Dnmt3a^tm3.2Enl involves: 129S4/SvJae	premature death	J:91108

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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