Dnmt3a Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Dnmt3a
DNA methyltransferase 3A
MGI:1261827

19 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Apc^Min/Apc⁺ Col1a1^{tm12(tetO-Dnmt3a_i1)Jae}/Col1a1⁺ Gt(ROSA)26Sor^{tm1(rtTAM2)Jae}/Gt(ROSA)26Sor⁺ involves: 129S4/SvJae C57BL/6 * C57BL/6J	normal neoplasm	J:127808
Dnmt3a^em1Hsas/Dnmt3a^em1Hsas Dnmt3l^em1Hsas/Dnmt3l^em1Hsas C57BL/6J-Dnmt3a^em1Hsas Dnmt3l^em1Hsas	abnormal DNA methylation during gametogenesis	J:347433
	abnormal fertility/fecundity	J:347433
	abnormal imprinting	J:347433
	abnormal seminiferous tubule morphology	J:347433
	abnormal spermatid morphology	J:347433
	normal embryo phenotype	J:347433
	external male genitalia hypoplasia	J:347433
	normal mortality/aging	J:347433
	normal reproductive system phenotype	J:347433
	teratozoospermia	J:347433
Dnmt3a^tm1Enl/Dnmt3a^tm1Enl Dnmt3b^tm1Enl/Dnmt3b^tm1Enl involves: 129S4/SvJae * C57BL/6	absent somites	J:58298
	embryonic lethality, complete penetrance	J:58298
	incomplete embryo turning	J:58298
Dnmt3a^tm1Jae/Dnmt3a^tm1Jae Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ Nkx2-2^tm2.1Suss/Nkx2-2^tm2.1Suss Tg(Ins2-cre)23Herr/0 involves: 129S/Sv * Black Swiss * C57BL/6 * CBA/J * SJL	abnormal pancreatic beta cell differentiation	J:177838
Dnmt3a^tm1Jae/Dnmt3a^tm1Jae Nkx2-2^tm2.1Suss/Nkx2-2^tm2.1Suss Tg(Ins2-cre)23Herr/0 involves: Black Swiss * C57BL/6 * CBA/J * SJL	decreased pancreatic beta cell number	J:177838
	increased pancreatic alpha cell number	J:177838
Dnmt3a^tm1Trow/Dnmt3a⁺ Gt(ROSA)26Sor^{tm3(CAG-flpo/ERT2)Alj}/Gt(ROSA)26Sor⁺ Npm1^tm1Trow/Npm1⁺ Tg(Mx1-cre)1Cgn/0 B6.Cg-Gt(ROSA)26Sor^{tm3(CAG-flpo/ERT2)Alj} Npm1^tm1Trow Dnmt3a^tm1Trow Tg(Mx1-cre)1Cgn	abnormal bone marrow cell physiology	J:272803
Dnmt3a^tm2Enl/Dnmt3a^tm2Enl Dnmt3b^tm1Enl/Dnmt3b^tm1Enl involves: 129S4/SvJae * C57BL/6	abnormal DNA methylation	J:116773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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