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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Vrk1
vaccinia related kinase 1
MGI:1261847
30 phenotypes from 3 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Vrk1em1(IMPC)Mbp/Vrk1+
C57BL/6N-Vrk1em1(IMPC)Mbp/Ucd 		abnormal behavior J:211773
decreased thigmotaxis J:211773
increased circulating alanine transaminase level J:211773
increased circulating aspartate transaminase level J:211773
Vrk1em1(IMPC)Mbp/Vrk1em1(IMPC)Mbp
C57BL/6N-Vrk1em1(IMPC)Mbp/Ucd 		embryonic lethality prior to organogenesis J:211773
embryonic lethality prior to tooth bud stage J:211773
preweaning lethality, complete penetrance J:211773
Vrk1Gt(RRR178)Byg/Vrk1Gt(RRR178)Byg
B6.129P2-Vrk1Gt(RRR178)Byg 		abnormal oocyte morphology J:207272
abnormal ovary tissue architecture J:207272
decreased secondary ovarian follicle number J:207272
decreased tertiary ovarian follicle number J:207272
early reproductive senescence J:171525
female infertility J:171525
impaired ovarian folliculogenesis J:207272
male infertility J:171525
Vrk1Gt(RRR178)Byg/Vrk1Gt(RRR178)Byg
FVB.129P2(B6)-Vrk1Gt(RRR178)Byg 		female infertility J:171525
male infertility J:171525
Vrk1Gt(RRR178)Byg/Vrk1Gt(RRR178)Byg
involves: 129P2/OlaHsd * C57BL/6 		abnormal epididymis morphology J:156653
abnormal female meiosis J:171525
abnormal oogenesis J:171525
abnormal seminiferous tubule morphology J:156653
abnormal spermatid morphology J:156653
abnormal spermatogenesis J:156653, J:171525
abnormal spermatogonia proliferation J:156653
azoospermia J:156653
decreased male germ cell number J:156653, J:171525
decreased testis weight J:171525
early reproductive senescence J:171525
female infertility J:156653, J:171525
impaired fertilization J:171525
impaired polar body extrusion J:171525
male infertility J:156653, J:171525
seminiferous tubule degeneration J:156653, J:171525
small testis J:156653
Vrk1Gt(XH078)Byg/Vrk1Gt(XH078)Byg
involves: 129P2/OlaHsd * C57BL/6 		no abnormal phenotype detected J:156653
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory