Cry1 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cry1
cryptochrome circadian regulator 1
MGI:1270841

36 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Ciart^{tm1e(KOMP)Wtsi}/Ciart^{tm1e(KOMP)Wtsi} Cry1^tm1Asn/Cry1^tm1Asn involves: 129P2/OlaHsd * C57BL/6N	abnormal homeostasis	J:205586
Cry1^tm1Asn/Cry1^tm1Asn Cry2^tm1Asn/Cry2^tm1Asn involves: 129P2/OlaHsd	increased bone mass	J:115188
	increased osteoblast cell number	J:115188
	normal vision/eye phenotype	J:81500
Cry1^tm1Asn/Cry1^tm1Asn Cry2^tm1Asn/Cry2^tm1Asn involves: 129P2/OlaHsd * C57BL/6	abnormal brown adipose tissue morphology	J:128437
	abnormal circadian regulation of heart rate	J:128437
	abnormal circadian temperature homeostasis	J:128437
	arrhythmic circadian behavior persistence	J:58114
	decreased abdominal adipose tissue amount	J:128437
	decreased body weight	J:128437
	decreased subcutaneous adipose tissue amount	J:128437
	decreased total body fat amount	J:128437
	impaired glucose tolerance	J:128437
	increased insulin sensitivity	J:128437
	increased oxygen consumption	J:128437
Cry1^tm1Asn/Cry1^tm1Asn Cry2^tm1Asn/Cry2^tm1Asn Pde6b^rd1/Pde6b^rd1 involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6	abnormal circadian behavior phase	J:66580
	abnormal locomotor circadian rhythm	J:66580
	abnormal retina morphology	J:66580
	abnormal retina outer nuclear layer morphology	J:66580
	absent photoreceptor outer segment	J:66580
	absent retina rod cells	J:66580
	decreased locomotor activity	J:66580
	decreased retina cone cell number	J:66580
	impaired pupillary reflex	J:81500
	retina degeneration	J:66580
Cry1^tm1Asn/Cry1^tm1Asn Cry2^tm1Hnos/Cry2^tm1Hnos involves: 129P2/OlaHsd * C57BL/6J	abnormal baroreceptor physiology	J:134129
	abnormal circadian behavior	J:134129
	abnormal circadian regulation of heart rate	J:134129
	abnormal circadian regulation of systemic arterial blood pressure	J:134129
	abnormal vasoconstriction	J:134129
	decreased body weight	J:134129
Cry1^tm1Asn/Cry1^tm1Asn Fbxl3^tm1.1Ljp/Fbxl3^tm1.1Ljp involves: 129P2/OlaHsd	abnormal circadian behavior period	J:194250
Cry1^tm1Asn/Cry1^tm1Asn Pde6b^rd1/Pde6b^rd1 involves: 129P2/OlaHsd	impaired pupillary reflex	J:81500
Cry1^tm1Jhjh/Cry1⁺ Cry2^tm1Jhjh/Cry2^tm1Jhjh involves: 129P2/OlaHsd * C57BL/6	abnormal circadian behavior period	J:54241
Cry1^tm1Jhjh/Cry1^tm1Jhjh Cry2^tm1Jhjh/Cry2⁺ involves: 129P2/OlaHsd * C57BL/6	abnormal circadian behavior	J:54241
Cry1^tm1Jhjh/Cry1^tm1Jhjh Cry2^tm1Jhjh/Cry2^tm1Jhjh involves: 129P2/OlaHsd * C57BL/6	abnormal circadian behavior period	J:54241
	abnormal T cell activation	J:159504
	arrhythmic circadian behavior persistence	J:54241
	increased circulating interleukin-1 beta level	J:159504
	increased circulating interleukin-6 level	J:159504
	increased circulating tumor necrosis factor level	J:159504
	increased susceptibility to induced arthritis	J:159504
	increased tumor necrosis factor secretion	J:159504
Cry1^tm1Jhjh/Cry1^tm1Jhjh Per2^tm1Brd/Per2^tm1Brd involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6	arrhythmic circadian behavior persistence	J:79492

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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