Rps6kb1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Rps6kb1
ribosomal protein S6 kinase, polypeptide 1
MGI:1270849

25 phenotypes from 2 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Rps6kb1^tm1Gtho/Rps6kb1^tm1Gtho B6.129P2-Rps6kb1^tm1Gtho	abnormal pancreatic beta cell morphology	J:144599
	abnormal pancreatic beta cell physiology	J:144599
	decreased body weight	J:144599
	decreased circulating insulin level	J:144599
	decreased pancreatic beta cell mass	J:144599
	increased insulin sensitivity	J:144599
	postnatal growth retardation	J:89696
Rps6kb1^tm1Gtho/Rps6kb1^tm1Gtho involves: 129P2/OlaHsd	decreased skeletal muscle fiber diameter	J:129852
Rps6kb1^tm1Gtho/Rps6kb1^tm1Gtho involves: 129P2/OlaHsd * C57BL/6	decreased body size	J:52107, J:89696
	decreased body weight	J:52107
	decreased circulating insulin level	J:66406
	decreased embryo size	J:89696
	decreased insulin secretion	J:66406
	decreased pancreatic beta cell mass	J:66406
	hyperglycemia	J:66406
	impaired glucose tolerance	J:66406
	postnatal growth retardation	J:52107, J:89696
	small pancreatic islets	J:66406
Rps6kb1^tm1Nte/Rps6kb1^tm1Nte involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal muscle regeneration	J:155912
	abnormal tibialis anterior morphology	J:155912
	decreased body size	J:155912, J:244749
	decreased epididymal fat pad weight	J:244749
	decreased inguinal fat pad weight	J:244749
	decreased interscapular fat pad weight	J:244749
	decreased mesenteric fat pad weight	J:244749
	decreased retroperitoneal fat pad weight	J:244749
	decreased skeletal muscle weight	J:155912
	extended life span	J:244749
	increased carbon dioxide production	J:244749
	increased oxygen consumption	J:244749

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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