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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Rps6kb1
ribosomal protein S6 kinase, polypeptide 1
MGI:1270849
25 phenotypes from 2 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Rps6kb1tm1Gtho/Rps6kb1tm1Gtho
B6.129P2-Rps6kb1tm1Gtho 		abnormal pancreatic beta cell morphology J:144599
abnormal pancreatic beta cell physiology J:144599
decreased body weight J:144599
decreased circulating insulin level J:144599
decreased pancreatic beta cell mass J:144599
increased insulin sensitivity J:144599
postnatal growth retardation J:89696
Rps6kb1tm1Gtho/Rps6kb1tm1Gtho
involves: 129P2/OlaHsd 		decreased skeletal muscle fiber diameter J:129852
Rps6kb1tm1Gtho/Rps6kb1tm1Gtho
involves: 129P2/OlaHsd * C57BL/6 		decreased body size J:52107, J:89696
decreased body weight J:52107
decreased circulating insulin level J:66406
decreased embryo size J:89696
decreased insulin secretion J:66406
decreased pancreatic beta cell mass J:66406
hyperglycemia J:66406
impaired glucose tolerance J:66406
postnatal growth retardation J:52107, J:89696
small pancreatic islets J:66406
Rps6kb1tm1Nte/Rps6kb1tm1Nte
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal muscle regeneration J:155912
abnormal tibialis anterior morphology J:155912
decreased body size J:155912, J:244749
decreased epididymal fat pad weight J:244749
decreased inguinal fat pad weight J:244749
decreased interscapular fat pad weight J:244749
decreased mesenteric fat pad weight J:244749
decreased retroperitoneal fat pad weight J:244749
decreased skeletal muscle weight J:155912
extended life span J:244749
increased carbon dioxide production J:244749
increased oxygen consumption J:244749
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory