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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Rps6kb1
ribosomal protein S6 kinase, polypeptide 1
MGI:1270849
34 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Eprs1tm2.1Xen/Eprs1tm2.1Xen
Rps6kb1tm1Nte/Rps6kb1tm1Nte
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		decreased body size J:244749
decreased epididymal fat pad weight J:244749
decreased inguinal fat pad weight J:244749
decreased interscapular fat pad weight J:244749
decreased mesenteric fat pad weight J:244749
decreased retroperitoneal fat pad weight J:244749
Ptentm1Hwu/Ptentm1Hwu
Rps6kb1tm1Gtho/Rps6kb1tm1Gtho
Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA 		enlarged spleen J:169097
enlarged thymus J:169097
increased acute lymphoblastic leukemia incidence J:169097
premature death J:169097
Rps6kb1tm1Gtho/Rps6kb1tm1Gtho
Rps6kb2tm1Gtho/Rps6kb2+
involves: 129P2/OlaHsd * C57BL/6 		postnatal lethality, incomplete penetrance J:89696
Rps6kb1tm1Gtho/Rps6kb1tm1Gtho
Rps6kb2tm1Gtho/Rps6kb2tm1Gtho
B6.129P2-Rps6kb1tm1Gtho Rps6kb2tm1Gtho 		neonatal lethality, incomplete penetrance J:89696
perinatal lethality, incomplete penetrance J:89696
postnatal growth retardation J:89696
postnatal lethality, incomplete penetrance J:89696
Rps6kb1tm1Gtho/Rps6kb1tm1Gtho
Rps6kb2tm1Gtho/Rps6kb2tm1Gtho
involves: 129P2/OlaHsd 		abnormal cellular respiration J:129852
abnormal lipid level J:129852
abnormal mitochondrial morphology J:129852
abnormal muscle physiology J:129852
abnormal skeletal muscle morphology J:129852
decreased skeletal muscle fiber diameter J:129852
increased fatty acid beta-oxidation J:129852
increased skeletal muscle glycogen level J:129852
Rps6kb1tm1Gtho/Rps6kb1tm1Gtho
Rps6kb2tm1Gtho/Rps6kb2tm1Gtho
involves: 129P2/OlaHsd * C57BL/6 		abnormal blood circulation J:89696
abnormal heart morphology J:89696
cyanosis J:89696
decreased litter size J:89696
hemorrhage J:89696
hypoxia J:89696
neonatal lethality, incomplete penetrance J:89696
perinatal lethality, incomplete penetrance J:89696
postnatal growth retardation J:89696
postnatal lethality, incomplete penetrance J:89696
Rps6kb1tm1Gtho/Rps6kb1tm1Gtho
Rps6kb2tm1Gtho/Rps6kb2tm1Gtho
Tg(Ins2-Akt1*)3Mbb/0
involves: 129P2/OlaHsd * C57BL/6 * SJL 		abnormal pancreatic beta cell morphology J:144599
normal neoplasm J:144599
Rps6kb1tm1Gtho/Rps6kb1tm1Gtho
Tg(Ins2-Akt1*)3Mbb/0
B6.Cg-Rps6kb1tm1Gtho Tg(Ins2-Akt1*)3Mbb 		abnormal pancreatic beta cell morphology J:144599
decreased body weight J:144599
decreased circulating glucose level J:144599
decreased circulating insulin level J:144599
increased insulin sensitivity J:144599
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory