Slc6a2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Slc6a2
solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
MGI:1270850

30 phenotypes from 4 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Slc6a2^tm1.1Hhg/Slc6a2^tm1.1Hhg B6.129P2(Cg)-Slc6a2^tm1.1Hhg	impaired behavioral response to cocaine	J:101977
	impaired behavioral response to xenobiotic	J:101977
Slc6a2^tm1.1Mkh/Slc6a2⁺ B6.129S6-Slc6a2^tm1.1Mkh	abnormal noradrenaline level	J:200046
	behavioral despair	J:200046
	normal cardiovascular system phenotype	J:200046
	increased anxiety-related response	J:200046
	increased circulating noradrenaline level	J:200046
	increased heart rate	J:200046
	increased thigmotaxis	J:200046
	normal nervous system phenotype	J:200046
Slc6a2^tm1.1Mkh/Slc6a2^tm1.1Mkh B6.129S6-Slc6a2^tm1.1Mkh	abnormal noradrenaline level	J:200046
	increased circulating adrenaline level	J:200046
	increased dopamine level	J:200046
Slc6a2^{tm1b(EUCOMM)Hmgu}/Slc6a2⁺ C57BL/6N-Slc6a2^{tm1b(EUCOMM)Hmgu}/H	decreased hemoglobin content	J:211773
	impaired glucose tolerance	J:211773
Slc6a2^{tm1b(EUCOMM)Hmgu}/Slc6a2^{tm1b(EUCOMM)Hmgu} C57BL/6N-Slc6a2^{tm1b(EUCOMM)Hmgu}/H	abnormal gait	J:211773
	preweaning lethality, incomplete penetrance	J:211773
	small heart	J:211773
Slc6a2^tm1Mca/Slc6a2^tm1Mca B6.129S4-Slc6a2^tm1Mca	enhanced long-term potentiation	J:89778
Slc6a2^tm1Mca/Slc6a2^tm1Mca involves: 129S4/SvJaeSor	abnormal noradrenaline level	J:66729
	abnormal physiological response to xenobiotic	J:66729
	decreased locomotor activity	J:66729
	decreased vertical activity	J:66729
	increased chemically-elicited antinociception	J:66729
	increased thermal nociceptive threshold	J:66729
Slc6a2^tm1Mca/Slc6a2^tm1Mca involves: 129S4/SvJaeSor * C57BL/6J	abnormal emotion/affect behavior	J:61825
	abnormal nervous system physiology	J:61825
	decreased body temperature	J:61825
	decreased body weight	J:61825
	enhanced behavioral response to addictive substance	J:61825
	enhanced behavioral response to cocaine	J:61825
	increased physiological sensitivity to xenobiotic	J:61825

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24