Robo1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Robo1
roundabout guidance receptor 1
MGI:1274781

55 phenotypes from 6 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Robo1^b2b872Clo/Robo1^b2b872Clo C57BL/6J-Robo1^b2b872Clo	abnormal craniofacial morphology	J:244438
	abnormal heart morphology	J:244438
	abnormal kidney morphology	J:175213
	abnormal sex gland morphology	J:175213
	atrioventricular septal defect	J:244438
	cleft palate	J:175213, J:244438
	double outlet right ventricle	J:175213, J:244438
	heart left ventricle hypertrophy	J:175213
	heart right ventricle hypertrophy	J:175213
	hydronephrosis	J:175213
	hydroureter	J:175213
	micrognathia	J:175213, J:244438
	muscular ventricular septal defect	J:244438
	ostium secundum atrial septal defect	J:244438
	perimembraneous ventricular septal defect	J:244438
	polycystic kidney	J:175213
	short snout	J:244438
	ventricular septal defect	J:175213
Robo1^em1(IMPC)Mbp/Robo1⁺ C57BL/6N-Robo1^em1(IMPC)Mbp/MbpMmucd	abnormal behavior	J:211773
	decreased anxiety-related response	J:211773
	decreased locomotor activity	J:211773
	decreased thigmotaxis	J:211773
	no spontaneous movement	J:211773
Robo1^em1(IMPC)Mbp/Robo1^em1(IMPC)Mbp C57BL/6N-Robo1^em1(IMPC)Mbp/MbpMmucd	abnormal placenta morphology	J:211773
	no spontaneous movement	J:211773
	preweaning lethality, complete penetrance	J:211773
	preweaning lethality, incomplete penetrance	J:211773
Robo1^tm1.1Ljr/Robo1^tm1.1Ljr B6.129-Robo1^tm1.1Ljr	abnormal axon extension	J:109478
	abnormal axon guidance	J:109478
	abnormal brain commissure morphology	J:109478
	abnormal corpus callosum morphology	J:109478
	abnormal hippocampal commissure morphology	J:109478
	decreased corpus callosum size	J:109478
	decreased hippocampal commissure size	J:109478
	enhanced neuronal migration	J:109478
	perinatal lethality, complete penetrance	J:109478
Robo1^tm1Matl/Robo1^tm1Matl involves: 129X1/SvJ	abnormal mammary gland duct morphology	J:106011, J:141875
	abnormal olfactory tract morphology	J:119469
	increased mammary gland epithelial cell proliferation	J:141875
Robo1^tm1Matl/Robo1^tm1Matl involves: CD-1	abnormal axon guidance	J:89780
Robo1^tm1Matl/Robo1^tm1Matl involves: CD-1	abnormal spinal cord lateral column morphology	J:89780
Robo1^tm1Phr/Robo1⁺ involves: 129P2/OlaHsd * C57BL/6	increased carcinoma incidence	J:93666
	increased lung adenocarcinoma incidence	J:93666
	increased lymphoma incidence	J:93666
Robo1^tm1Phr/Robo1^tm1Phr involves: 129P2/OlaHsd * C57BL/6	abnormal bronchiole morphology	J:73485
	abnormal bronchus morphology	J:73485
	abnormal lung development	J:73485
	abnormal lung morphology	J:73485
	abnormal pulmonary alveolus morphology	J:73485
	abnormal pulmonary interalveolar septum morphology	J:73485
	aphagia	J:73485
	bronchial epithelial hyperplasia	J:73485
	neonatal lethality, incomplete penetrance	J:73485
	respiratory failure	J:73485
	thick pulmonary interalveolar septum	J:73485
Robo1^tm1Wian/Robo1^tm1Wian involves: 129S/SvEv	perimembraneous ventricular septal defect	J:244438
Robo1^tm1Wian/Robo1^tm1Wian involves: 129S/SvEv * C57BL/6	abnormal embryonic/fetal subventricular zone morphology	J:130430
Robo1^tm1Wian/Robo1^tm1Wian involves: 129S/SvEv * C57BL/6	abnormal neurite morphology	J:130430

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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