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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ep300
E1A binding protein p300
MGI:1276116
92 phenotypes from 7 alleles in 10 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cd19tm1(cre)Cgn/Cd19+
Ep300tm2Reck/Ep300+
involves: 129/Sv * 129P2/OlaHsd * C57BL/6 		abnormal adaptive immunity J:147840
abnormal B cell differentiation J:147840
abnormal humoral immune response J:147840
abnormal renal glomerulus morphology J:147840
abnormal spleen marginal zone macrophage morphology J:147840
abnormal transitional stage B cell morphology J:147840
arteritis J:147840
decreased B cell proliferation J:147840
decreased marginal zone B cell number J:147840
enlarged lymph nodes J:147840
enlarged spleen J:147840
extramedullary hematopoiesis J:147840
glomerulonephritis J:147840
increased activated T cell number J:147840
increased anti-double stranded DNA antibody level J:147840
increased B cell apoptosis J:147840
increased B cell number J:147840
increased IgG2b level J:147840
increased immunoglobulin level J:147840
increased megakaryocyte cell number J:147840
increased spleen weight J:147840
increased susceptibility to systemic lupus erythematosus J:147840
intermingled spleen red and white pulp J:147840
kidney inflammation J:147840
premature death J:147840
renal fibrosis J:147840
renal glomerular protein deposits J:147840
Cd19tm1(cre)Cgn/Cd19+
Ep300tm2Reck/Ep300+
involves: 129/Sv * 129P2/OlaHsd * FVB/N 		increased susceptibility to systemic lupus erythematosus J:147840
premature death J:147840
Ep300Plt6/Ep300Plt6
involves: 129S1/Sv * C57BL/6 		decreased B cell number J:140200
decreased eosinophil cell number J:140200
decreased leukocyte cell number J:140200
decreased lymphocyte cell number J:140200
postnatal lethality J:140200
thrombocytosis J:140200
Ep300tm1Dli/Ep300+
either: 129S4/SvJae or (involves: 129S4/SvJae * C57BL/6) 		decreased embryo size J:47301
embryonic lethality during organogenesis, incomplete penetrance J:47301
exencephaly J:47301
open neural tube J:47301
Ep300tm1Dli/Ep300+
involves: 129S4/SvJae * C57BL/6 		normal hematopoietic system phenotype J:60630
normal neoplasm J:60630
Ep300tm1Dli/Ep300tm1Dli
either: 129S4/SvJae or (involves: 129S4/SvJae * C57BL/6) 		abnormal cell physiology J:47301
abnormal vitelline vasculature morphology J:47301
absent trabeculae carneae J:47301
decreased cardiac muscle contractility J:47301
decreased embryo size J:47301
decreased fibroblast proliferation J:47301
early cellular replicative senescence J:47301
embryonic growth retardation J:47301
embryonic lethality during organogenesis, incomplete penetrance J:47301
enlarged heart J:47301
incomplete embryo turning J:47301
incomplete somite formation J:47301
pericardial effusion J:47301
Ep300tm1Dli/Ep300tm1Dli
involves: 129S4/SvJae * C57BL/6 		abnormal facial morphology J:47301
decreased embryo size J:47301
embryonic growth arrest J:47301
embryonic lethality during organogenesis, complete penetrance J:47301
exencephaly J:47301
kinked neural tube J:47301
microphthalmia J:47301
open neural tube J:47301
Ep300tm1Pkb/Ep300+
involves: 129P2/OlaHsd * C57BL/6 		thrombocytosis J:98329
Ep300tm1Pkb/Ep300tm1Pkb
involves: 129P2/OlaHsd * C57BL/6 		abnormal erythrocyte morphology J:98329
anemia J:98329
anisocytosis J:98329
decreased body size J:98329
decreased thymocyte number J:98329
increased megakaryocyte cell number J:98329
postnatal lethality, incomplete penetrance J:98329
thrombocytosis J:98329
Ep300tm1Reck/Ep300+
involves: 129P2/OlaHsd 		abnormal atrioventricular septum morphology J:85949
abnormal epicardium development J:85949
abnormal heart development J:85949
abnormal heart valve morphology J:85949
abnormal intestinal epithelium morphology J:85949
abnormal lung development J:85949
abnormal muscle fiber morphology J:85950
abnormal muscle morphology J:85950
abnormal myogenesis J:85950
abnormal small intestinal villus morphology J:85949
abnormal small intestine morphology J:85949
abnormal vasculogenesis J:85949
atrial septal defect J:85949
cyanosis J:85949
decreased body size J:85949
decreased skeletal muscle fiber size J:85950
delayed heart development J:85949
edema J:85949, J:85950
embryonic lethality during organogenesis, incomplete penetrance J:85949, J:85950
hemorrhage J:85949
internal hemorrhage J:85949
lethality throughout fetal growth and development, incomplete penetrance J:85949, J:85950
myocardium hypoplasia J:85949
perimembraneous ventricular septal defect J:85949
perinatal lethality, complete penetrance J:85949, J:85950
respiratory failure J:85949
thin myocardium J:85949
thin ventricle myocardium compact layer J:85949
thin ventricular wall J:85949
ventricular septal defect J:85949
Ep300tm2Pkb/Ep300tm2Pkb
Tg(Lck-cre)548Jxm/0
involves: 129P2/OlaHsd * C57BL/6 * CBA 		decreased single-positive T cell number J:105505
decreased thymocyte number J:105505
increased double-positive T cell number J:105505
small thymus J:105505
Ep300tm2Pkb/Ep300tm2Pkb
Tg(MMTV-cre)4Mam/0
involves: 129P2/OlaHsd * FVB 		normal neoplasm J:105505
Ep300tm3Pkb/Ep300tm3Pkb
involves: 129S6/SvEvTac * C57BL/6 		postnatal lethality, incomplete penetrance J:103607
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory