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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ep300
E1A binding protein p300
MGI:1276116
22 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Crebbptm1Dli/Crebbp+
Ep300tm1Dli/Ep300+
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 		decreased embryo size J:47301
exencephaly J:47301
open neural tube J:47301
prenatal lethality, complete penetrance J:47301
Crebbptm1Jvd/Crebbptm1Jvd
Ep300tm2Pkb/Ep300tm2Pkb
Tg(Lck-cre)548Jxm/0
involves: 129P2/OlaHsd * C57BL/6 * CBA 		abnormal T cell number J:105505
decreased double-positive T cell number J:105505
increased double-negative T cell number J:105505
Crebbptm2Pkb/Crebbp+
Ep300tm3Pkb/Ep300+
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 		abnormal craniofacial morphology J:103607
decreased body size J:103607
Crebbptm2Pkb/Crebbp+
Ep300tm3Pkb/Ep300tm3Pkb
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 		embryonic lethality during organogenesis, incomplete penetrance J:103607
Crebbptm2Pkb/Crebbptm2Pkb
Ep300tm3Pkb/Ep300tm3Pkb
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 		embryonic lethality during organogenesis J:103607
Ep300Plt6/Ep300+
Mpltm1Wsa/Mpltm1Wsa
involves: 129S1/Sv * C57BL/6 		abnormal megakaryocyte progenitor cell morphology J:140200
abnormal platelet morphology J:140200
increased eosinophil cell number J:140200
increased megakaryocyte cell number J:140200
Ep300Plt6/Ep300Plt6
Mpltm1Wsa/Mpltm1Wsa
involves: 129S1/Sv * C57BL/6 		abnormal megakaryocyte progenitor cell morphology J:140200
increased megakaryocyte cell number J:140200
postnatal lethality J:140200
thrombocytosis J:140200
Ep300tm1.1Wtp/Ep300tm1.1Wtp
involves: 129S4/SvJae * C57BL/6 * SJL * Swiss Webster 		no abnormal phenotype detected J:185868
Ep300tm1Pkb/Ep300+
Mybtm1Ssp/Myb+
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 		abnormal megakaryocyte morphology J:98329
decreased thymocyte number J:98329
thrombocytosis J:98329
Ep300tm3Pkb/Ep300+
Tg(IghMyc)22Bri/0
involves: 129S6/SvEvTac * C57BL * SJL 		abnormal tumor susceptibility J:103607
Ep300tm3Pkb/Ep300+
Tg(IghMyc)22Bri/0
involves: 129S6/SvEvTac * C57BL/6 		abnormal tumor incidence J:103607
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory