Ncoa1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ncoa1
nuclear receptor coactivator 1
MGI:1276523

44 phenotypes from 5 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ncoa1^{tm1.1(KOMP)Vlcg}/Ncoa1^{tm1.1(KOMP)Vlcg} C57BL/6N-Ncoa1^{tm1.1(KOMP)Vlcg}/Ucd	abnormal brain morphology	J:211773
	decreased fasting circulating glucose level	J:211773
	decreased total body fat amount	J:211773
	hydrocephaly	J:211773
	hyperactivity	J:211773
	increased bone mineral content	J:211773
	increased circulating alkaline phosphatase level	J:211773
	increased grip strength	J:211773
	increased lean body mass	J:211773
	increased lung weight	J:211773
Ncoa1^tm1.1Hkaw/Ncoa1^tm1.1Hkaw B6.Cg-Ncoa1^tm1.1Hkaw	abnormal bone remodeling	J:111490
	abnormal urine homeostasis	J:111490
	decreased bone mineral content	J:111490
	decreased bone mineral density	J:111490
	decreased bone mineral density of femur	J:111490
	decreased bone volume	J:111490
	decreased circulating testosterone level	J:111490
	increased bone resorption	J:111490
	increased circulating alkaline phosphatase level	J:111490
	increased circulating estradiol level	J:111490
	increased circulating leptin level	J:111490
	obese	J:111490
	osteoporosis	J:111490
	testis hypoplasia	J:111490
Ncoa1^tm1Bwo/Ncoa1^tm1Bwo involves: 129 * C57BL/6	normal reproductive system phenotype	J:101966
Ncoa1^tm1Bwo/Ncoa1^tm1Bwo involves: 129 * C57BL/6J	normal immune system phenotype	J:109522
Ncoa1^tm1Bwo/Ncoa1^tm1Bwo involves: 129/Sv * C57BL/6	abnormal cerebellar Purkinje cell layer	J:81201
	abnormal cerebellum morphology	J:81201
	abnormal decidualization	J:46528
	abnormal female reproductive system morphology	J:46528
	abnormal male reproductive system morphology	J:46528
	abnormal mammary gland development	J:46528
	abnormal Purkinje cell morphology	J:81201
	abnormal response/metabolism to endogenous compounds	J:126521
	abnormal spatial learning	J:81201
	abnormal thyroid hormone level	J:54182
	impaired coordination	J:81201
	increased circulating thyroid-stimulating hormone level	J:54182, J:126521
	increased circulating thyroxine level	J:126521
	increased circulating triiodothyronine level	J:126521
	increased thyroxine level	J:54182
	increased triiodothyronine level	J:54182
	small prostate gland	J:46528
	small testis	J:46528
Ncoa1^tm1Hkaw/Ncoa1^tm1Hkaw involves: C57BL/6J	no abnormal phenotype detected	J:111490
Ncoa1^tm1Jkr/Ncoa1^tm1Jkr involves: 129P2/OlaHsd * C57BL/6J	no abnormal phenotype detected	J:53063

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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