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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ncoa3
nuclear receptor coactivator 3
MGI:1276535
109 phenotypes from 6 alleles in 8 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ncoa3tm1.1Bwo/Ncoa3tm1.1Bwo
involves: 129S/SvEv * C57BL/6J 		abnormal cell differentiation J:161276
abnormal defecation J:161276
abnormal eating behavior J:161276
abnormal exercise endurance J:161276
abnormal glucose homeostasis J:161276
abnormal hormone level J:161276
decreased adiponectin level J:161276
decreased body temperature J:161276
decreased carbon dioxide production J:161276
decreased circulating glucagon level J:161276
decreased locomotor activity J:161276
decreased oxygen consumption J:161276
normal homeostasis/metabolism phenotype J:161276
hyperglycemia J:161276
impaired adaptive thermogenesis J:161276
impaired glucose tolerance J:161276
increased body weight J:161276
increased circulating insulin-like growth factor I level J:161276
increased circulating leptin level J:161276
increased fat cell size J:161276
increased incidence of tumors by chemical induction J:161276
increased liver glycogen level J:161276
increased liver triglyceride level J:161276
increased total body fat amount J:161276
insulin resistance J:161276
oliguria J:161276
Ncoa3tm1b(EUCOMM)Wtsi/Ncoa3+
C57BL/6N-Ncoa3tm1b(EUCOMM)Wtsi/H 		abnormal tooth morphology J:211773
impaired glucose tolerance J:211773
increased circulating bilirubin level J:211773
increased mean corpuscular hemoglobin J:211773
persistence of hyaloid vascular system J:211773
thrombocytopenia J:211773
Ncoa3tm1b(EUCOMM)Wtsi/Ncoa3tm1b(EUCOMM)Wtsi
C57BL/6N-Ncoa3tm1b(EUCOMM)Wtsi/H 		abnormal tooth morphology J:211773
persistence of hyaloid vascular system J:211773
preweaning lethality, incomplete penetrance J:211773
Ncoa3tm1Jxu/Ncoa3tm1Jxu
involves: 129S6/SvEvTac 		abnormal branching of the mammary ductal tree J:62724
abnormal female reproductive system physiology J:62724
abnormal mammary gland development J:62724
abnormal vagina epithelium morphology J:62724
cachexia J:62724
decreased body weight J:62724
decreased circulating estradiol level J:62724
decreased circulating insulin-like growth factor I level J:62724
decreased fibroblast cell migration J:88789
decreased litter size J:62724
decreased superovulation rate J:62724
delayed sexual maturation J:62724
delayed vaginal opening J:62724
disproportionate dwarf J:62724
postnatal growth retardation J:62724
preweaning lethality, incomplete penetrance J:62724
prolonged estrous cycle J:62724
rough coat J:62724
Ncoa3tm1Jxu/Ncoa3tm1Jxu
involves: 129S6/SvEvTac * C57BL/6 		decreased circulating glucose level J:120086
decreased interleukin-1 beta secretion J:120086
impaired adaptive thermogenesis J:120086
increased circulating interleukin-1 beta level J:120086
increased circulating interleukin-6 level J:120086
increased circulating tumor necrosis factor level J:120086
increased interleukin-6 secretion J:120086
increased susceptibility to bacterial infection induced morbidity/mortality J:120086
increased susceptibility to endotoxin shock J:120086
increased tumor necrosis factor secretion J:120086
Ncoa3tm1Jxu/Ncoa3tm1Jxu
involves: 129S6/SvEvTac * C57BL/6J 		abnormal adipose tissue morphology J:117159
abnormal B cell morphology J:109522
abnormal brown fat cell morphology J:144060
abnormal cell differentiation J:117159
abnormal epididymal fat pad morphology J:117159
abnormal lymphopoiesis J:109522
abnormal skeletal muscle fiber morphology J:144060
abnormal spleen red pulp morphology J:109522
decreased body weight J:109522, J:117159, J:144060
decreased brown adipose tissue amount J:144060
decreased brown fat cell lipid droplet size J:144060
decreased brown fat cell size J:144060
decreased circulating cholesterol level J:144060
decreased circulating free fatty acids level J:144060
decreased circulating glucose level J:144060
decreased circulating HDL cholesterol level J:144060
decreased circulating insulin level J:144060
decreased circulating triglyceride level J:144060
decreased epididymal fat pad weight J:117159
decreased liver weight J:144060
decreased splenocyte apoptosis J:109522
decreased susceptibility to diet-induced hepatic steatosis J:144060
decreased susceptibility to diet-induced obesity J:144060
decreased total body fat amount J:117159, J:144060
decreased white adipose tissue amount J:117159, J:144060
decreased white fat cell size J:117159
enlarged spleen J:109522
impaired exercise endurance J:144060
improved glucose tolerance J:144060
increased B cell derived lymphoma incidence J:109522
increased B cell number J:109522
increased B cell proliferation J:109522
increased carbon dioxide production J:144060
increased CD4-positive, alpha-beta T cell number J:109522
increased CD8-positive, alpha-beta T cell number J:109522
increased energy expenditure J:144060
increased insulin sensitivity J:144060
increased leukocyte cell number J:109522
increased lymphocyte cell number J:109522
increased lymphoma incidence J:109522
increased mitochondrial size J:144060
increased oxygen consumption J:144060
increased respiratory quotient J:144060
increased spleen germinal center size J:109522
increased T cell proliferation J:109522
premature death J:109522
small liver J:144060
thrombocytopenia J:109522
Ncoa3tm1Rsd/Ncoa3tm1Rsd
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal cell physiology J:66454
decreased body size J:66454
decreased body weight J:66454
decreased cell proliferation J:66454
decreased circulating insulin-like growth factor I level J:66454
decreased embryo size J:66454
normal endocrine/exocrine gland phenotype J:66454
lowered ear position J:66454
Ncoa3tm2.1Jxu/Ncoa3tm2.1Jxu
involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 		no abnormal phenotype detected J:161101
Ncoa3tm2.2Jxu/Ncoa3tm2.2Jxu
involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N 		decreased body weight J:161101
decreased circulating insulin-like growth factor I level J:161101
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/17/2024
MGI 6.24 		The Jackson Laboratory