About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ncoa3
nuclear receptor coactivator 3
MGI:1276535
109 phenotypes from 6 alleles in 8 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Ncoa3tm1.1Bwo/Ncoa3tm1.1Bwo
involves: 129S/SvEv * C57BL/6J 		abnormal cell differentiation J:161276
abnormal defecation J:161276
abnormal eating behavior J:161276
abnormal exercise endurance J:161276
abnormal glucose homeostasis J:161276
abnormal hormone level J:161276
decreased adiponectin level J:161276
decreased body temperature J:161276
decreased carbon dioxide production J:161276
decreased circulating glucagon level J:161276
decreased locomotor activity J:161276
decreased oxygen consumption J:161276
normal homeostasis/metabolism phenotype J:161276
hyperglycemia J:161276
impaired adaptive thermogenesis J:161276
impaired glucose tolerance J:161276
increased body weight J:161276
increased circulating insulin-like growth factor I level J:161276
increased circulating leptin level J:161276
increased fat cell size J:161276
increased incidence of tumors by chemical induction J:161276
increased liver glycogen level J:161276
increased liver triglyceride level J:161276
increased total body fat amount J:161276
insulin resistance J:161276
oliguria J:161276
Ncoa3tm1b(EUCOMM)Wtsi/Ncoa3+
C57BL/6N-Ncoa3tm1b(EUCOMM)Wtsi/H 		abnormal tooth morphology J:211773
impaired glucose tolerance J:211773
increased circulating bilirubin level J:211773
increased mean corpuscular hemoglobin J:211773
persistence of hyaloid vascular system J:211773
thrombocytopenia J:211773
Ncoa3tm1b(EUCOMM)Wtsi/Ncoa3tm1b(EUCOMM)Wtsi
C57BL/6N-Ncoa3tm1b(EUCOMM)Wtsi/H 		abnormal tooth morphology J:211773
persistence of hyaloid vascular system J:211773
preweaning lethality, incomplete penetrance J:211773
Ncoa3tm1Jxu/Ncoa3tm1Jxu
involves: 129S6/SvEvTac 		abnormal branching of the mammary ductal tree J:62724
abnormal female reproductive system physiology J:62724
abnormal mammary gland development J:62724
abnormal vagina epithelium morphology J:62724
cachexia J:62724
decreased body weight J:62724
decreased circulating estradiol level J:62724
decreased circulating insulin-like growth factor I level J:62724
decreased fibroblast cell migration J:88789
decreased litter size J:62724
decreased superovulation rate J:62724
delayed sexual maturation J:62724
delayed vaginal opening J:62724
disproportionate dwarf J:62724
postnatal growth retardation J:62724
preweaning lethality, incomplete penetrance J:62724
prolonged estrous cycle J:62724
rough coat J:62724
Ncoa3tm1Jxu/Ncoa3tm1Jxu
involves: 129S6/SvEvTac * C57BL/6 		decreased circulating glucose level J:120086
decreased interleukin-1 beta secretion J:120086
impaired adaptive thermogenesis J:120086
increased circulating interleukin-1 beta level J:120086
increased circulating interleukin-6 level J:120086
increased circulating tumor necrosis factor level J:120086
increased interleukin-6 secretion J:120086
increased susceptibility to bacterial infection induced morbidity/mortality J:120086
increased susceptibility to endotoxin shock J:120086
increased tumor necrosis factor secretion J:120086
Ncoa3tm1Jxu/Ncoa3tm1Jxu
involves: 129S6/SvEvTac * C57BL/6J 		abnormal adipose tissue morphology J:117159
abnormal B cell morphology J:109522
abnormal brown fat cell morphology J:144060
abnormal cell differentiation J:117159
abnormal epididymal fat pad morphology J:117159
abnormal lymphopoiesis J:109522
abnormal skeletal muscle fiber morphology J:144060
abnormal spleen red pulp morphology J:109522
decreased body weight J:109522, J:117159, J:144060
decreased brown adipose tissue amount J:144060
decreased brown fat cell lipid droplet size J:144060
decreased brown fat cell size J:144060
decreased circulating cholesterol level J:144060
decreased circulating free fatty acids level J:144060
decreased circulating glucose level J:144060
decreased circulating HDL cholesterol level J:144060
decreased circulating insulin level J:144060
decreased circulating triglyceride level J:144060
decreased epididymal fat pad weight J:117159
decreased liver weight J:144060
decreased splenocyte apoptosis J:109522
decreased susceptibility to diet-induced hepatic steatosis J:144060
decreased susceptibility to diet-induced obesity J:144060
decreased total body fat amount J:117159, J:144060
decreased white adipose tissue amount J:117159, J:144060
decreased white fat cell size J:117159
enlarged spleen J:109522
impaired exercise endurance J:144060
improved glucose tolerance J:144060
increased B cell derived lymphoma incidence J:109522
increased B cell number J:109522
increased B cell proliferation J:109522
increased carbon dioxide production J:144060
increased CD4-positive, alpha-beta T cell number J:109522
increased CD8-positive, alpha-beta T cell number J:109522
increased energy expenditure J:144060
increased insulin sensitivity J:144060
increased leukocyte cell number J:109522
increased lymphocyte cell number J:109522
increased lymphoma incidence J:109522
increased mitochondrial size J:144060
increased oxygen consumption J:144060
increased respiratory quotient J:144060
increased spleen germinal center size J:109522
increased T cell proliferation J:109522
premature death J:109522
small liver J:144060
thrombocytopenia J:109522
Ncoa3tm1Rsd/Ncoa3tm1Rsd
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal cell physiology J:66454
decreased body size J:66454
decreased body weight J:66454
decreased cell proliferation J:66454
decreased circulating insulin-like growth factor I level J:66454
decreased embryo size J:66454
normal endocrine/exocrine gland phenotype J:66454
lowered ear position J:66454
Ncoa3tm2.1Jxu/Ncoa3tm2.1Jxu
involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 		no abnormal phenotype detected J:161101
Ncoa3tm2.2Jxu/Ncoa3tm2.2Jxu
involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N 		decreased body weight J:161101
decreased circulating insulin-like growth factor I level J:161101
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory