Alx3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Alx3
aristaless-like homeobox 3
MGI:1277097

24 phenotypes from 1 allele in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Alx3^tm1Hubr/Alx3⁺ involves: 129P2/OlaHsd	impaired glucose tolerance	J:166436
Alx3^tm1Hubr/Alx3⁺ involves: 129P2/OlaHsd	increased circulating glucose level	J:166436
Alx3^tm1Hubr/Alx3^tm1Hubr involves: 129P2/OlaHsd	abnormal pancreatic beta cell physiology	J:166436
	decreased insulin secretion	J:166436
	decreased pancreatic beta cell mass	J:166436
	normal homeostasis/metabolism phenotype	J:166436
	impaired glucose tolerance	J:166436
	increased circulating insulin level	J:166436
	increased fasting circulating glucose level	J:166436
	increased pancreatic beta cell apoptosis	J:166436
	insulin resistance	J:166436
	small pancreatic islets	J:166436
Alx3^tm1Hubr/Alx3^tm1Hubr involves: 129P2/OlaHsd * C57BL/6 * FVB/N	abnormal cell death	J:163651
	abnormal craniofacial development	J:163651
	abnormal embryonic neuroepithelium morphology	J:163651
	abnormal head mesenchyme morphology	J:163651
	embryonic growth retardation	J:163651
	exencephaly	J:163651
	failure of eyelid fusion	J:163651
	midline facial cleft	J:163651
	neonatal lethality, incomplete penetrance	J:163651
	open neural tube	J:163651
	preweaning lethality, incomplete penetrance	J:163651
	reduced female fertility	J:163651
Alx3^tm1Hubr/Alx3^tm1Hubr involves: 129P2/OlaHsd * FVB/N	normal skeleton phenotype	J:71880

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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