Snca Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Snca
synuclein, alpha
MGI:1277151

44 phenotypes from 10 alleles in 9 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Snca^em1(IMPC)H/Snca^em1(IMPC)H C57BL/6NTac-Snca^em1(IMPC)H/H	abnormal locomotor behavior	J:211773
	increased circulating amylase level	J:211773
	increased circulating creatinine level	J:211773
	increased fasting circulating glucose level	J:211773
	increased mean platelet volume	J:211773
	increased spleen weight	J:211773
	prolonged PR interval	J:211773
Snca^tm1.1Koks/Snca⁺ either: B6.129P2-Snca^tm1.1Koks or (involves: 129P2/OlaHsd * C57BL/6)	abnormal locomotor activation	J:201391
	catalepsy	J:201391
	decreased dopamine level	J:201391
	decreased physiological sensitivity to xenobiotic	J:201391
	impaired coordination	J:201391
	long stride length	J:201391
Snca^tm1.1Vlb/Snca^tm1.1Vlb involves: C57BL/6	no abnormal phenotype detected	J:101977
Snca^tm1Nbm/Snca^tm1Nbm involves: 129S6/SvEvTac * FVB/N	normal mortality/aging	J:124976
Snca^tm1Rosl/Snca^tm1Rosl B6.129X1-Snca^tm1Rosl	normal behavior/neurological phenotype	J:92213
	decreased dopaminergic neuron number	J:92213
	decreased susceptibility to dopaminergic neuron neurotoxicity	J:92213
	normal nervous system phenotype	J:86439, J:92213
Snca^tm1Rosl/Snca^tm1Rosl involves: 129X1/SvJ	decreased susceptibility to bacterial infection	J:138194
Snca^tm1Rosl/Snca^tm1Rosl involves: 129X1/SvJ * C57BL/6	abnormal dopaminergic neuron morphology	J:60151
	abnormal locomotor activation	J:60151
	decreased dopamine level	J:60151
Snca^tm1Sud/Snca^tm1Sud involves: 129P2/OlaHsd * C57BL/6	abnormal dopaminergic neuron morphology	J:93686
Snca^tm1Wtd/Snca^tm1Wtd involves: 129	abnormal miniature excitatory postsynaptic currents	J:94390, J:126092
	abnormal respiratory electron transport chain	J:79993
	abnormal synaptic transmission	J:94390
	normal cellular phenotype	J:101289
	decreased susceptibility to dopaminergic neuron neurotoxicity	J:79993
	increased physiological sensitivity to xenobiotic	J:79993
	reduced long-term potentiation	J:94390, J:126092
Tg(Thy1-Snca)1S13Putt/? involves: C57BL/6	abnormal axon morphology	J:177661
	abnormal brainstem morphology	J:177661
	abnormal dendrite morphology	J:177661
	abnormal motor capabilities/coordination/movement	J:177661
	abnormal motor neuron morphology	J:177661
	abnormal muscle fiber morphology	J:177661
	abnormal neuromuscular synapse morphology	J:177661
	abnormal neuron morphology	J:177661
	abnormal spinal cord morphology	J:177661
	alpha-synuclein inclusion body	J:177661, J:207278
	astrocytosis	J:177661
	axon degeneration	J:177661
	decreased body weight	J:177661
	demyelination	J:177661
	impaired coordination	J:177661
	increased mitochondrial size	J:177661
	microgliosis	J:177661
	premature death	J:177661
Tg(THY1-Snca)M1mSud/0 involves: C57BL/6	normal nervous system phenotype	J:115193
Tg(THY1-Snca)M2mSud/0 involves: C57BL/6	no abnormal phenotype detected	J:133654

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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