Parl Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Parl
presenilin associated, rhomboid-like
MGI:1277152

46 phenotypes from 3 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Parl^tm1.1Bdes/Parl^tm1.1Bdes involves: 129P2/OlaHsd	abnormal mitochondrial crista morphology	J:269785
	abnormal mitochondrial morphology	J:269785
	abnormal mitochondrial physiology	J:269785
	abnormal respiratory electron transport chain	J:269785
	abnormal thymus apoptosis	J:269785
	abnormal vasculogenesis	J:269785
	abnormal voluntary movement	J:269785
	astrocytosis	J:269785
	brainstem hemorrhage	J:269785
	encephalopathy	J:269785
	hunched posture	J:269785
	internal hemorrhage	J:269785
	microgliosis	J:269785
	muscular atrophy	J:269785
	neuron degeneration	J:269785
	paresis	J:269785
	premature death	J:269785
	respiratory distress	J:269785
	spinal hemorrhage	J:269785
	spleen atrophy	J:269785
	thymus atrophy	J:269785
Parl^tm1.1Bdes/Parl^tm1.1Bdes involves: 129P2/OlaHsd * C57BL/6J	abnormal B cell morphology	J:116017
	abnormal cell physiology	J:116017
	abnormal male reproductive system morphology	J:116017
	abnormal mitochondrial physiology	J:116017
	abnormal nerve conduction	J:116017
	abnormal nervous system physiology	J:116017
	abnormal uterine environment	J:116017
	cachexia	J:116017
	cryptorchism	J:116017
	decreased B cell number	J:116017
	decreased double-positive T cell number	J:116017
	decreased lymphocyte cell number	J:116017
	decreased skeletal muscle fiber diameter	J:116017
	decreased skeletal muscle mass	J:116017
	increased neuron apoptosis	J:116017
	increased T cell apoptosis	J:116017
	kyphosis	J:116017
	muscular atrophy	J:116017
	neurodegeneration	J:116017
	postnatal growth retardation	J:116017
	premature death	J:116017
	respiratory distress	J:116017
	small epididymis	J:116017
	small testis	J:116017
	spleen atrophy	J:116017
	thymus atrophy	J:116017
Parl^{tm1a(EUCOMM)Hmgu}/Parl⁺ C57BL/6N-Parl^{tm1a(EUCOMM)Hmgu}/H	increased mean corpuscular volume	J:165965
Parl^tm1Bdes/Parl^tm1Bdes Tg(Ckmm-cre)5Khn/0 involves: 129P2/OlaHsd * FVB	normal behavior/neurological phenotype	J:269785
	normal mortality/aging	J:269785
Parl^tm1Bdes/Parl^tm1Bdes Tg(Nes-cre)1Kln/0 involves: 129P2/OlaHsd * C57BL/6 * SJL	abnormal mitochondrial morphology	J:269785
	abnormal thymus apoptosis	J:269785
	liver degeneration	J:269785
	muscular atrophy	J:269785
	neurodegeneration	J:269785
	premature death	J:269785
	normal reproductive system phenotype	J:269785
	spleen atrophy	J:269785
	thymus atrophy	J:269785

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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