Cdk6 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cdk6
cyclin dependent kinase 6
MGI:1277162

48 phenotypes from 7 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cdk6^tm1.1Phin/Cdk6^tm1.1Phin involves: 129S4/SvJae * C57BL/6	normal immune system phenotype	J:144975
Cdk6^{tm1b(EUCOMM)Wtsi}/Cdk6^{tm1b(EUCOMM)Wtsi} C57BL/6N-Cdk6^{tm1b(EUCOMM)Wtsi}/Tcp	abnormal eye morphology	J:211773
	increased mean corpuscular hemoglobin	J:211773
	increased mean corpuscular volume	J:211773
	small superior vagus ganglion	J:211773
Cdk6^tm1Bbd/Cdk6^tm1Bbd involves: 129S1/Sv * 129X1/SvJ * CD-1	abnormal definitive hematopoiesis	J:92529
	abnormal erythrocyte morphology	J:92529
	abnormal hematopoietic system morphology/development	J:92529
	abnormal spleen morphology	J:92529
	abnormal spleen red pulp morphology	J:92529
	abnormal thymus morphology	J:92529
	decreased body weight	J:92529
	decreased erythrocyte cell number	J:92529
	decreased leukocyte cell number	J:92529
	decreased mature ovarian follicle number	J:92529
	decreased megakaryocyte cell number	J:92529
	decreased T cell proliferation	J:92529
	increased mean corpuscular hemoglobin concentration	J:92529
	increased mean corpuscular volume	J:92529
	increased single-positive T cell number	J:92529
	reduced female fertility	J:92529
	small spleen	J:92529
	spleen hypoplasia	J:92529
	thymus cortex atrophy	J:92529
	thymus hypoplasia	J:92529
Cdk6^tm1Phin/Cdk6^tm1Phin involves: 129S4/SvJae	abnormal lymphopoiesis	J:144975
	abnormal T cell differentiation	J:144975
	abnormal thymocyte activation	J:144975
	decreased CD8-positive, alpha-beta T cell number	J:144975
	decreased double-negative T cell number	J:144975
	decreased double-positive T cell number	J:144975
	decreased thymocyte apoptosis	J:144975
	decreased thymocyte number	J:144975
	thymus atrophy	J:144975
	thymus hypoplasia	J:144975
Cdk6^tm1Phin/Cdk6^tm1Phin involves: 129S4/SvJae * C57BL/6	abnormal hematopoietic stem cell physiology	J:174697
	decreased DN1 thymic pro-T cell number	J:174697
	decreased DN2 thymocyte number	J:174697
	decreased double-positive T cell number	J:174697
	decreased hematopoietic stem cell number	J:174697
	normal immune system phenotype	J:174697
	increased CD4-positive, alpha-beta T cell number	J:174697
	increased CD8-positive, alpha-beta T cell number	J:174697
	increased DN3 thymocyte number	J:174697
Cdk6^tm2.1Phin/Cdk6^tm2.1Phin involves: 129 * C57BL/6 * FVB/N	abnormal hematopoietic stem cell physiology	J:174697
	abnormal T cell differentiation	J:174697
	decreased DN1 thymic pro-T cell number	J:174697
	decreased DN2 thymocyte number	J:174697
	decreased DN4 thymocyte number	J:174697
	decreased double-positive T cell number	J:174697
	decreased hematopoietic stem cell number	J:174697
	decreased thymocyte number	J:174697
	increased CD4-positive, alpha-beta T cell number	J:174697
	increased CD8-positive, alpha-beta T cell number	J:174697
	increased DN3 thymocyte number	J:174697
	increased double-negative T cell number	J:174697
	small thymus	J:174697
Cdk6^tm3.1Phin/Cdk6^tm3.1Phin involves: 129 * C57BL/6 * FVB/N	abnormal hematopoietic stem cell physiology	J:174697
	abnormal T cell differentiation	J:174697
	enlarged thymus	J:174697
	normal immune system phenotype	J:174697
	increased CD4-positive, alpha-beta T cell number	J:174697
	increased DN1 thymic pro-T cell number	J:174697
	increased hematopoietic stem cell number	J:174697
	increased T cell apoptosis	J:174697
	increased thymocyte number	J:174697
Cdk6^tm4.1Phin/Cdk6^tm4.1Phin involves: 129 * C57BL/6 * FVB/N	abnormal hematopoietic stem cell physiology	J:174697
	abnormal T cell differentiation	J:174697
	decreased DN1 thymic pro-T cell number	J:174697
	decreased DN2 thymocyte number	J:174697
	decreased DN4 thymocyte number	J:174697
	decreased double-positive T cell number	J:174697
	decreased thymocyte number	J:174697
	normal immune system phenotype	J:174697
	increased CD4-positive, alpha-beta T cell number	J:174697
	increased CD8-positive, alpha-beta T cell number	J:174697
	increased DN3 thymocyte number	J:174697
	increased hematopoietic stem cell number	J:174697
	small thymus	J:174697

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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