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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Atg5
autophagy related 5
MGI:1277186
127 phenotypes from 4 alleles in 20 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Atg5em1Smoc/Atg5em1Smoc
S100a4em1(cre)Zhyg/S100a4+
involves: C57BL/6J 		abnormal tumor morphology J:330821
decreased tumor growth/size J:330821
Atg5Gt(IRESBetageo)4Pgr/Atg5Gt(IRESBetageo)4Pgr
involves: 129S1/Sv * 129X1/SvJ * NMRI 		no abnormal phenotype detected J:48376
Atg5tm1Myok/Atg5tm1Myok
involves: 129S/SvEv 		normal cellular phenotype J:232686
Atg5tm1Myok/Atg5tm1Myok
involves: 129S/SvEv * C57BL/6 		no abnormal phenotype detected J:110050
Atg5tm1Myok/Atg5tm1Myok
A1cfTg(Myh6-cre/Esr1*)1Jmk/?
involves: 129S/SvEv * FVB/N 		abnormal cardiac muscle contractility J:121778
abnormal myocardial fiber physiology J:121778
dilated heart left ventricle J:121778
increased heart weight J:121778
increased lung weight J:121778
increased myocardial fiber size J:121778
Atg5tm1Myok/Atg5tm1Myok
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * 129S/SvEv 		abnormal circulating chemokine level J:235399
abnormal kidney morphology J:235399
abnormal macrophage physiology J:235399
abnormal renal glomerulus morphology J:235399
decreased body weight J:235399
decreased circulating interleukin-10 level J:235399
glomerulonephritis J:235399
increased anti-double stranded DNA antibody level J:235399
increased anti-nuclear antigen antibody level J:235399
increased autoantibody level J:235399
increased blood urea nitrogen level J:235399
increased circulating creatinine level J:235399
increased circulating interleukin-1 beta level J:235399
increased circulating interleukin-6 level J:235399
increased circulating interleukin-12b level J:235399
increased IgG level J:235399
increased lymphocyte cell number J:235399
increased monocyte cell number J:235399
increased neutrophil cell number J:235399
increased susceptibility to systemic lupus erythematosus J:235399
increased urine protein level J:235399
Atg5tm1Myok/Atg5tm1Myok
Myl2tm1(cre)Krc/Myl2+
involves: 129S/SvEv * 129S4/SvJae 		abnormal cardiovascular system physiology J:121778
congestive heart failure J:121778
dilated heart left ventricle J:121778
increased physiological sensitivity to xenobiotic J:121778
increased susceptibility to induced morbidity/mortality J:121778
Atg5tm1Myok/Atg5tm1Myok
Tg(BEST1-cre)1Taf/0
involves: 129S/SvEv * C57BL/6J 		abnormal autophagy J:200084
decreased a-wave amplitude J:200084
decreased b-wave amplitude J:200084
normal vision/eye phenotype J:200084
Atg5tm1Myok/Atg5tm1Myok
Tg(CAG-cre)13Miya/?
involves: 129S/SvEv * C57BL/6 		abnormal liver morphology J:110050
Atg5tm1Myok/Atg5tm1Myok
Tg(Kap-cre)1Isa/0
involves: 129S/SvEv * C57BL/6 * DBA 		abnormal proximal convoluted tubule morphology J:179961
alaninuria J:179961
aminoaciduria J:179961
normal homeostasis/metabolism phenotype J:179961
hyperthreoninuria J:179961
impaired autophagy J:179961
increased kidney weight J:179961
increased urine glucose level J:179961
normal mortality/aging J:179961
tryptophanuria J:179961
valinuria J:179961
Atg5tm1Myok/Atg5tm1Myok
Tg(Kap-icre)29066/2Sig/0
involves: 129S/SvEv * C57BL/6J * SJL 		increased susceptibility to induced morbidity/mortality J:293453
Atg5tm1Myok/Atg5tm1Myok
Tg(Mx1-cre)1Cgn/?
involves: 129S/SvEv * C57BL/6 * CBA 		abnormal liver morphology J:110050
Atg5tm1Myok/Atg5tm1Myok
Tg(Myh6-cre)2182Mds/?
involves: 129S/SvEv * C57BL/6 * FVB/N 		no abnormal phenotype detected J:121778
Atg5tm1Myok/Atg5tm1Myok
Tg(Nes-cre)1Kln/?
involves: 129S/SvEv * C57BL/6 * SJL 		abnormal axon morphology J:110050
abnormal behavior J:110050
abnormal brain morphology J:110050
abnormal cell physiology J:110050
abnormal cerebellar granule cell morphology J:110050
abnormal cerebral cortex morphology J:110050
abnormal hippocampus morphology J:110050
abnormal inferior colliculus morphology J:110050
abnormal motor capabilities/coordination/movement J:110050
abnormal suckling behavior J:110050
abnormal thalamus morphology J:110050
ataxia J:110050
decreased body weight J:110050
decreased cerebral cortex pyramidal cell number J:110050
decreased grip strength J:110050
impaired coordination J:110050
limb grasping J:110050
neuron degeneration J:110050
neuronal intranuclear inclusions J:110050
postnatal growth retardation J:110050
premature death J:110050
Purkinje cell degeneration J:110050
short stride length J:110050
tremors J:110050
Atg5tm1Myok/Atg5tm1Myok
Tg(Pomc1-cre)1Gsb/0
involves: 129S/SvEv * C57BL/6 * FVB/N 		abnormal autophagy J:232686
normal adipose tissue phenotype J:232686
normal growth/size/body region phenotype J:232686
normal nervous system phenotype J:232686
Atg5tm1Myok/Atg5tm1Myok
Tg(SFTPC-cre)11Yo/0
involves: 129S/SvEv * C57BL/6 		normal mortality/aging J:300057
Atg5tm1Myok/Atg5tm1Myok
Tg(Stra8-icre)1Reb/0
involves: 129S/SvEv * FVB/NJ 		abnormal acrosome assembly J:307712
abnormal cauda epididymis morphology J:307712
abnormal sperm end piece morphology J:307712
abnormal sperm flagellum morphology J:307712
abnormal sperm head morphology J:307712
abnormal sperm individualization J:307712
abnormal sperm midpiece morphology J:307712
abnormal sperm mitochondrial sheath morphology J:307712
abnormal sperm nucleus morphology J:307712
abnormal spermiation J:307712
abnormal spermiogenesis J:307712
abnormal testis physiology J:307712
absent sperm fibrous sheath J:307712
asthenozoospermia J:307712
decreased testis weight J:307712
double-headed sperm J:307712
globozoospermia J:307712
immotile sperm J:307712
impaired autophagy J:307712
male infertility J:307712
multinucleated giant male germ cells J:307712
oligozoospermia J:307712
reduced male fertility J:307712
short sperm flagellum J:307712
teratozoospermia J:307712
Atg5tm1Myok/Atg5tm1Myok
Tg(Vil1-cre)997Gum/0
involves: 129S/SvEv * C57BL/6 * SJL 		abnormal Paneth cell morphology J:141419
impaired autophagy J:141419
Atg5tm1Myok/Atg5tm1Myok
Tg(Vil1-cre)1000Gum/0
involves: 129S/SvEv * C57BL/6J * SJL/J 		abnormal intestinal goblet cell morphology J:206181
Atg5tm1Nmz/Atg5tm1Nmz
B6.129-Atg5tm1Nmz/NmzRbrc 		normal respiratory system phenotype J:300057
Atg5tm1Nmz/Atg5tm1Nmz
involves: 129 * BALB/c * C57BL/6 		abnormal thymus cortex morphology J:140583
Atg5tm1Nmz/Atg5tm1Nmz
involves: 129S1/Sv * 129X1/SvJ 		abnormal adenohypophysis morphology J:110050
abnormal adrenal gland morphology J:110050
abnormal brain morphology J:110050
abnormal hepatocyte morphology J:110050
abnormal liver morphology J:110050
abnormal utricle morphology J:163712
absent otoliths J:163712
enlarged otoliths J:163712
neuronal intranuclear inclusions J:110050
Atg5tm1Nmz/Atg5tm1Nmz
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal amino acid level J:104491
abnormal circulating amino acid level J:104491
abnormal lysosome morphology J:104491
abnormal ST segment J:104491
absent gastric milk in neonates J:104491
normal hematopoietic system phenotype J:103983
neonatal lethality, complete penetrance J:104491
normal vision/eye phenotype J:103983
Atg5tm1Nmz/Atg5tm1Nmz
Tg(Cd4-cre)1Cwi/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 		abnormal T cell morphology J:211733
abnormal T cell physiology J:211733
abnormal T cell subpopulation ratio J:211733
decreased CD4-positive, alpha-beta T cell number J:211733
decreased CD8-positive, alpha-beta T cell number J:211733
decreased T cell number J:211733
decreased T cell proliferation J:211733
impaired autophagy J:211733
increased mitochondrial size J:211733
oxidative stress J:211733
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory