Atg5 Phenotype Annotations - Multigenic Genotypes

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Atg5
autophagy related 5
MGI:1277186

13 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Atg5^tm1.1Myok/Atg5^tm1.1Myok Col1a1^{tm3(tetO-Pou5f1,-Sox2,-Klf4,-Myc)Jae}/Col1a1⁺ involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N	abnormal cell physiology	J:205532
Atg5^tm1Myok/Atg5^tm1Myok Cnot3^tm1.1Kjkb/Cnot3^tm1.1Kjkb Tg(Ckmm-cre)5Khn/0 involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * FVB	abnormal autophagosome formation	J:260012
	decreased cardiac muscle contractility	J:260012
	increased heart weight	J:260012
	premature death	J:260012
	prolonged QT interval	J:260012
Atg5^tm1Myok/Atg5^tm1Myok Rheb^tm1.1Otsu/Rheb^tm1.1Otsu Tg(Myh6-cre)2182Mds/0 involves: 129S/SvEv * C57BL/6J * FVB/N	postnatal lethality, complete penetrance	J:197831
Atg5^tm1Myok/Atg5^tm1Myok Tg(CAG-EGFP/Map1lc3b)53Nmz/0 Tg(Cryaa-cre)10Mlr/0 involves: 129S/SvEv * C57BL/6 * DBA/2 * FVB/N	abnormal lens fiber morphology	J:198392
	cataract	J:198392
	impaired autophagy	J:198392
Atg5^tm1Nmz/Atg5^tm1Nmz Tg(CAG-EGFP/Map1lc3b)53Nmz/? involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal autophagosome formation	J:140583
	abnormal thymus morphology	J:140583
	abnormal thymus physiology	J:140583
	neonatal lethality, complete penetrance	J:140583

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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