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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tyrobp
TYRO protein tyrosine kinase binding protein
MGI:1277211
59 phenotypes from 4 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Tyrobptm1.1Viv/Tyrobptm1.1Viv
B6.129P2-Tyrobptm1.1Viv 		abnormal axon morphology J:95232
abnormal bone ossification J:95232
abnormal bone remodeling J:95232, J:129304
abnormal excitatory postsynaptic currents J:96801
abnormal microglial cell morphology J:95232
abnormal myelination J:95232
abnormal myelopoiesis J:95232
abnormal osteoclast physiology J:95232, J:129304
decreased bone resorption J:95232, J:129304
enhanced long-term potentiation J:96801
increased bone mass J:95232, J:129304
increased bone mineral content J:95232
increased bone mineral density J:95232
increased bone trabecula number J:95232
increased physiological sensitivity to xenobiotic J:96801
increased trabecular bone volume J:95232
normal nervous system phenotype J:95232
osteopetrosis J:95232
Tyrobptm1.1Viv/Tyrobptm1.1Viv
involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 		decreased susceptibility to type IV hypersensitivity reaction J:64764
impaired natural killer cell mediated cytotoxicity J:64764
increased dendritic cell number J:64764
Tyrobptm1.1Viv/Tyrobptm1.1Viv
involves: 129P2/OlaHsd * C57BL/6 		abnormal decidua basalis morphology J:100668
abnormal maternal decidual layer morphology J:100668
abnormal uterine spiral artery morphology J:100668
abnormal uterine spiral artery remodeling J:100668
decreased uterine NK cell number J:100668
enlarged placenta J:100668
failure of embryo implantation J:100668
reduced fertility J:100668
Tyrobptm1Lll/Tyrobptm1Lll
B6.129P2-Tyrobptm1Lll 		abnormal NK T cell physiology J:147867
decreased interferon-gamma secretion J:147867
Tyrobptm1Lll/Tyrobptm1Lll
involves: 129P2/OlaHsd 		decreased susceptibility to induced arthritis J:158811
Tyrobptm1Lll/Tyrobptm1Lll
involves: 129P2/OlaHsd * C57BL/6 		abnormal osteoclast differentiation J:89583
decreased bone resorption J:89583
decreased interferon-gamma secretion J:64763
decreased susceptibility to experimental autoimmune encephalomyelitis J:64763
decreased T cell proliferation J:64763
normal immune system phenotype J:64763
impaired natural killer cell mediated cytotoxicity J:64763
increased dendritic cell number J:64763
increased natural killer cell mediated cytotoxicity J:64763
osteopetrosis J:89583
Tyrobptm1Ttk/Tyrobptm1Ttk
B6.129P2-Tyrobptm1Ttk 		increased anti-double stranded DNA antibody level J:177613
increased autoantibody level J:177613
increased B cell proliferation J:177613
increased germinal center B cell number J:177613
increased IgG2a level J:177613
increased IgG3 level J:177613
increased interleukin-6 secretion J:177613
increased spleen germinal center number J:177613
increased spleen germinal center size J:177613
Tyrobptm1Ttk/Tyrobptm1Ttk
involves: 129P2/OlaHsd * C57BL/6 		abnormal axon morphology J:81823
abnormal dendritic cell physiology J:110786
abnormal inhibitory postsynaptic currents J:81823
abnormal myelination J:81823
abnormal neuron morphology J:81823
abnormal oligodendrocyte morphology J:81823
abnormal osteoclast morphology J:81823
abnormal osteoclast physiology J:81823
normal behavior/neurological phenotype J:81823
decreased prepulse inhibition J:81823
decreased startle reflex J:81823
increased bone mineral density J:81823
increased bone mineral density of caudal vertebrae J:81823
increased bone mineral density of femur J:81823
increased trabecular bone mass J:81823
osteopetrosis J:81823
reduced sensorimotor gating J:81823
Tyrobptm1Viv/Tyrobptm1Viv
B6.129P2-Tyrobptm1Viv 		increased susceptibility to Herpesvirales infection J:124749
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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07/02/2024
MGI 6.13 		The Jackson Laboratory