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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Dlg4
discs large MAGUK scaffold protein 4
MGI:1277959
53 phenotypes from 7 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Dlg4tm1.1Tdoi/Dlg4tm1.1Tdoi
B6.Cg-Dlg4tm1.1Tdoi 		abnormal contextual conditioning behavior J:197875
abnormal discrimination learning J:197875
abnormal learning/memory/conditioning J:197875
abnormal maternal nurturing J:197875
abnormal social investigation J:197875
abnormal spatial learning J:197875
abnormal synaptic plasticity J:197875
abnormal synaptic transmission J:197875
decreased body size J:197875
decreased body weight J:197875
decreased locomotor activity J:197875
decreased neurotransmitter release J:197875
decreased startle reflex J:197875
decreased stereotypic behavior J:197875
enhanced long-term potentiation J:197875
enhanced paired-pulse facilitation J:197875
impaired coordination J:197875
impaired spatial working memory J:197875
increased anxiety-related response J:197875
increased grip strength J:197875
maternal effect J:197875
reduced AMPA-mediated synaptic currents J:197875
Dlg4tm1e(EUCOMM)Wtsi/Dlg4tm1e(EUCOMM)Wtsi
C57BL/6N-Dlg4tm1e(EUCOMM)Wtsi/Wtsi 		decreased grip strength J:211773
decreased total body fat amount J:211773
increased bone mineral content J:211773
increased circulating sodium level J:211773
increased lean body mass J:211773
tremors J:211773
Dlg4tm1Grnt/Dlg4tm1Grnt
involves: 129P2/OlaHsd * C57BL/6JIco 		abnormal sebaceous gland morphology J:209956
Dlg4tm1Grnt/Dlg4tm1Grnt
involves: 129P2/OlaHsd * MF1 		abnormal CNS synaptic transmission J:77693
abnormal forebrain morphology J:109664
abnormal hippocampus pyramidal cell morphology J:109664
abnormal pain threshold J:82335
abnormal spatial learning J:77693, J:98903
abnormal striatum morphology J:109664
allodynia J:82335
decreased body size J:77693
enhanced long-term potentiation J:77693, J:98903
enhanced paired-pulse facilitation J:77693
postnatal lethality, incomplete penetrance J:77693
Dlg4tm1Rlh/Dlg4tm1Rlh
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal AMPA-mediated synaptic currents J:118286
abnormal glutamate-mediated receptor currents J:118286
abnormal innervation J:118286
abnormal NMDA-mediated synaptic currents J:118286
enhanced long-term potentiation J:118286
Dlg4tm2.1Grnt/Dlg4tm2.1Grnt
involves: 129P2/OlaHsd 		decreased locomotor activity J:89778
decreased vertical activity J:89778
enhanced behavioral response to cocaine J:89778
enhanced long-term potentiation J:89778
impaired behavioral response to cocaine J:89778
Dlg4tm2.1Grnt/Dlg4tm2.1Grnt
involves: 129P2/OlaHsd * C57BL/6J 		abnormal anxiety-related response J:175436
abnormal dendritic spine morphology J:175436
abnormal learning/memory/conditioning J:175436
abnormal social investigation J:175436
decreased anxiety-related response J:175436
decreased grip strength J:175436
decreased locomotor activity J:175436
decreased vocalization J:175436
impaired balance J:175436
impaired coordination J:175436
increased circulating corticosterone level J:175436
increased grooming behavior J:175436
increased response to stress-induced hyperthermia J:175436
normal nervous system phenotype J:175436
Dlg4tm3.1Grnt/Dlg4tm3.1Grnt
involves: 129P2/OlaHsd * MF1 		normal nervous system phenotype J:152628
Dlg4tm4.1Grnt/Dlg4tm4.1Grnt
involves: 129P2/OlaHsd * MF1 		abnormal nociception after inflammation J:168384
normal nervous system phenotype J:168384
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory