Hus1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Hus1
HUS1 checkpoint clamp component
MGI:1277962

31 phenotypes from 4 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Hus1^tm1.1Rsw/Hus1^tm1.1Rsw involves: 129S4/SvJaeSor * 129S6/SvEvTac	abnormal developmental patterning	J:99339
	abnormal embryo turning	J:99339
	abnormal neural tube morphology	J:99339
	abnormal somite development	J:99339
	abnormal vitelline vasculature morphology	J:99339
	decreased embryo size	J:99339
	embryonic growth arrest	J:99339
	embryonic growth retardation	J:99339
	embryonic lethality during organogenesis, complete penetrance	J:99339
	failure of chorioallantoic fusion	J:99339
	incomplete rostral neuropore closure	J:99339
	increased embryonic tissue cell apoptosis	J:99339
	kinked neural tube	J:99339
Hus1^tm1Led/Hus1^tm1Led either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss)	abnormal allantois morphology	J:63869
	abnormal embryonic hematopoiesis	J:63869
	abnormal placenta labyrinth morphology	J:63869
	abnormal placental labyrinth vasculature morphology	J:63869
	abnormal somite development	J:63869
	abnormal somite shape	J:63869
	abnormal visceral yolk sac blood island morphology	J:63869
	abnormal visceral yolk sac morphology	J:63869
	abnormal vitelline vasculature morphology	J:63869
	absent fibroblast proliferation	J:63869
	absent limb buds	J:63869
	chromosome breakage	J:63869
	decreased embryo size	J:63869
	embryonic growth retardation	J:63869
	embryonic lethality during organogenesis, complete penetrance	J:63869
	failure of chorioallantoic fusion	J:63869
	failure of initiation of embryo turning	J:63869
	incomplete rostral neuropore closure	J:63869
	increased embryonic tissue cell apoptosis	J:63869
	kinked neural tube	J:63869
Hus1^tm1Led/Hus1^tm1Led involves: 129S6/SvEvTac	abnormal developmental patterning	J:99339
	abnormal neural tube morphology	J:99339
	decreased embryo size	J:99339
	embryonic growth retardation	J:99339
	increased embryonic tissue cell apoptosis	J:99339
Hus1^tm1Led/Hus1^tm1Rsw Tg(Hsp70-1-cre)1Arge/0 involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * CBA	prenatal lethality, incomplete penetrance	J:99339
Hus1^tm1Led/Hus1^tm2Rsw involves: 129S6/SvEvTac * C57BL/6	abnormal cell cycle checkpoint function	J:118898
	abnormal cell physiology	J:118898
	abnormal chromosome morphology	J:118898
	chromosome breakage	J:118898
	decreased cell proliferation	J:118898
	induced chromosome breakage	J:118898
	oxidative stress	J:118898

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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