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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Lrp5
low density lipoprotein receptor-related protein 5
MGI:1278315
91 phenotypes from 24 alleles in 23 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Lrp5em1Xjz/Lrp5em1Xjz
C57BL/6J-Lrp5em1Xjz 		abnormal retina development J:328283
decreased angiogenesis J:328283
Lrp5Gt(OST164883)Lex/Lrp5Gt(OST164883)Lex
involves: 129S5/SvEvBrd 		abnormal retina vasculature morphology J:154863
blood vessel congestion J:154863
increased vascular permeability J:154863
Lrp5Gt(OST164883)Lex/Lrp5Gt(OST164883)Lex
involves: 129S5/SvEvBrd * C57BL/6 		abnormal bone structure J:133196
abnormal long bone diaphysis morphology J:133196
abnormal lumbar vertebrae morphology J:133196
abnormal trabecular bone morphology J:133196
decreased body weight J:133196
decreased bone mass J:133196
decreased bone mineral density J:133196
decreased bone mineral density of femur J:133196
decreased bone ossification J:133196
decreased bone resorption J:133196
decreased compact bone mass J:133196
decreased trabecular bone mass J:133196
Lrp5m1Btlr/Lrp5+
C57BL/6J-Lrp5m1Btlr/Btlr 		decreased bone mineral density J:309727
Lrp5m1Btlr/Lrp5m1Btlr
C57BL/6J-Lrp5m1Btlr/Btlr 		decreased bone mass J:309727
decreased bone mineral density J:309727
fragile skeleton J:309727
Lrp5m2Btlr/Lrp5+
C57BL/6J-Lrp5m2Btlr/Btlr 		decreased bone mineral density J:309727
Lrp5m3Btlr/Lrp5m3Btlr
C57BL/6J-Lrp5m3Btlr/Btlr 		decreased bone mineral density J:309727
Lrp5m4Btlr/Lrp5m4Btlr
C57BL/6J-Lrp5m4Btlr/Btlr 		increased bone mineral density J:309727
Lrp5r18/Lrp5r18
C57BL/6J-Lrp5r18 		abnormal retina vasculature morphology J:135279
Lrp5tm1.1Mawa/Lrp5+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N 		increased bone mass J:172746
Lrp5tm1.1Mawa/Lrp5tm1.1Mawa
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N 		increased bone mass J:172746
Lrp5tm1.1Vari/Lrp5tm1.1Vari
involves: 129S1/Sv 		no abnormal phenotype detected J:178499
Lrp5tm1.1Vari/Lrp5tm1.2Vari
Twist2tm1(cre)Dor/Twist2+
involves: 129S1/Sv * 129X1/SvJ 		normal skeleton phenotype J:178499
Lrp5tm1.2Vari/Lrp5tm1.2Vari
involves: 129S1/Sv 		decreased bone mass J:178499
normal skeleton phenotype J:178499
Lrp5tm1Dgen/Lrp5tm1Dgen
B6.129P2-Lrp5tm1Dgen/J 		abnormal b-wave shape J:235600
abnormal retina blood vessel morphology J:235600
abnormal retina morphology J:235600
abnormal retina vasculature morphology J:235600
abnormal vascular plexus formation J:235600
abnormal vision J:235600
decreased total retina thickness J:235600
persistence of hyaloid vascular system J:169924, J:235600
Lrp5tm1Dgen/Lrp5tm1Dgen
involves: 129P2/OlaHsd * C57BL/6 		abnormal retina development J:328283
abnormal retina layer morphology J:101679
abnormal retina nerve fiber layer morphology J:101679
abnormal retina outer nuclear layer morphology J:101679
abnormal retina outer plexiform layer morphology J:101679
abnormal retina pigment epithelium morphology J:101679
decreased angiogenesis J:328283
decreased locomotor activity J:101679
disorganized retina inner nuclear layer J:101679
disorganized retina outer nuclear layer J:101679
disorganized retina outer plexiform layer J:101679
gliosis J:101679
hemorrhage J:328283
increased susceptibility to age-related retinal degeneration J:101679
increased thigmotaxis J:101679
retina fold J:101679
retina ganglion cell degeneration J:101679
retina photoreceptor degeneration J:101679
thin retina inner plexiform layer J:101679
thin retina outer nuclear layer J:101679
thin retina outer plexiform layer J:101679
Lrp5tm1Grw/Lrp5tm1Grw
involves: 129S1/Sv * 129X1/SvJ 		abnormal bone structure J:104382
abnormal osteoblast physiology J:104382
abnormal trabecular bone morphology J:104382
decreased bone mass J:104382, J:213541
decreased bone mineral content J:213541
decreased bone mineral density J:104382, J:213541
decreased bone mineralization J:104382, J:213541
decreased bone ossification J:104382
decreased bone stiffness J:213541
decreased bone strength J:213541
decreased bone volume J:213541
decreased compact bone mass J:213541
decreased osteoblast cell number J:104382
decreased osteoclast cell number J:104382
decreased trabecular bone mass J:213541
osteoporosis J:213541
Lrp5tm1Jfh/Lrp5tm1Jfh
involves: 129S5/SvEvBrd * C57BL/6 		abnormal phalanx morphology J:91055
Lrp5tm1Jsak/Lrp5+
involves: C57BL/6 * CBA 		decreased circulating insulin level J:81174
impaired glucose tolerance J:81174
increased cholesterol level J:81174
Lrp5tm1Jsak/Lrp5tm1Jsak
involves: C57BL/6 * CBA 		abnormal calcium ion homeostasis J:81174
abnormal femur morphology J:81174
abnormal limb morphology J:81174
abnormal liver physiology J:81174
decreased circulating insulin level J:81174
decreased diameter of femur J:81174
decreased diameter of tibia J:81174
decreased insulin secretion J:81174
impaired glucose tolerance J:81174
increased cholesterol level J:81174
increased circulating VLDL cholesterol level J:81174
insulin resistance J:81174
thin parietal bone J:81174
Lrp5tm1Kry/Lrp5+
either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) 		abnormal bone ossification J:75973
abnormal osteoblast physiology J:75973
decreased bone mass J:75973
decreased bone volume J:75973
delayed bone ossification J:75973
Lrp5tm1Kry/Lrp5+
involves: 129S1/Sv * 129X1/SvJ 		increased serotonin level J:146078
Lrp5tm1Kry/Lrp5tm1Kry
either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) 		abnormal bone ossification J:75973
abnormal eye development J:75973
abnormal osteoblast physiology J:75973
abnormal trabecular bone morphology J:75973
decreased apoptosis J:75973
decreased bone mass J:75973
decreased bone volume J:75973
decreased osteoblast cell number J:75973
delayed bone ossification J:75973
persistence of hyaloid vascular system J:75973
postnatal lethality, incomplete penetrance J:75973
normal skeleton phenotype J:75973
Lrp5tm1Kry/Lrp5tm1Kry
involves: 129S1/Sv * 129X1/SvJ 		abnormal bone mineralization J:216098
abnormal retina vasculature morphology J:135279, J:144980
decreased bone mass J:146078
decreased serotonin level J:146078
increased serotonin level J:146078
persistence of hyaloid vascular system J:101493, J:146078
normal skeleton phenotype J:146078
Lrp5tm1Lex/Lrp5+
involves: 129/Sv * C57BL/6J * FVB/N 		abnormal trabecular bone morphology J:111359
decreased bone mineral density J:111359
Lrp5tm1Lex/Lrp5tm1Lex
involves: 129/Sv * C57BL/6J * FVB/N 		decreased bone mineral density J:111359
persistence of hyaloid vascular system J:111359
Lrp5tm1Mawa/Lrp5+
involves: 129S1/Sv * 129X1/SvJ 		normal skeleton phenotype J:172746
Lrp5tm1Mawa/Lrp5+
Tg(Vil1-cre)997Gum/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL 		normal skeleton phenotype J:172746
Lrp5tm1Mawa/Lrp5+
Tg(Prrx1-cre)1Cjt/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL 		increased bone mass J:172746
Lrp5tm1Mawa/Lrp5+
Tg(Dmp1-cre)1Jqfe/0
involves: 129S1/Sv * 129S1/SvImj * 129X1/SvJ * FVB/N 		increased bone mass J:172746
Lrp5tm2.1Mawa/Lrp5+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N 		increased bone mass J:172746
Lrp5tm2.1Mawa/Lrp5tm2.1Mawa
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N 		increased bone mass J:172746
Lrp5tm2Kry/Lrp5+
Tg(Vil1-cre)20Syr/0
involves: C57BL/6 * DBA/2 		decreased bone mass J:146078
decreased bone ossification J:146078
Lrp5tm2Kry/Lrp5tm2Kry
Tg(Col1a1-cre)1Kry/0
involves: FVB 		normal homeostasis/metabolism phenotype J:146078
normal skeleton phenotype J:146078
normal vision/eye phenotype J:146078
Lrp5tm2Kry/Lrp5tm2Kry
Tg(Vil1-cre)20Syr/0
involves: C57BL/6 * DBA/2 		abnormal serotonin level J:146078
decreased bone mass J:146078
decreased bone ossification J:146078
decreased osteoblast cell number J:146078
decreased osteoblast proliferation J:146078
normal vision/eye phenotype J:146078
Lrp5tm2Mawa/Lrp5+
involves: 129S1/Sv * 129X1/SvJ 		normal skeleton phenotype J:172746
Lrp5tm2Mawa/Lrp5+
Tg(Vil1-cre)997Gum/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL 		normal skeleton phenotype J:172746
Lrp5tm2Mawa/Lrp5+
Tg(Prrx1-cre)1Cjt/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL 		increased bone mass J:172746
Lrp5tm2Mawa/Lrp5+
Tg(Dmp1-cre)1Jqfe/0
involves: 129S1/Sv * 129S1/SvImj * 129X1/SvJ * FVB/N 		increased bone mass J:172746
Lrp5tm3(Lrp5*)Kry/Lrp5tm3(Lrp5*)Kry
Tg(Col1a1-cre)1Kry/0
involves: FVB 		normal homeostasis/metabolism phenotype J:146078
normal skeleton phenotype J:146078
Lrp5tm3(Lrp5*)Kry/Lrp5tm3(Lrp5*)Kry
Tg(Vil1-cre)20Syr/0
involves: C57BL/6 * DBA/2 		decreased serotonin level J:146078
increased bone mass J:146078
increased bone ossification J:146078
Lrp5tm3.1Mawa/Lrp5tm3.1Mawa
Tg(Dmp1-cre)1Jqfe/0
involves: 129 * C57BL/6J * FVB/N 		decreased bone mass J:172746
Lrp5tm3.1Mawa/Lrp5tm3.1Mawa
Tg(Vil1-cre)997Gum/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL 		normal skeleton phenotype J:172746
Lrp5tm3.2Mawa/Lrp5tm3.2Mawa
involves: 129S1/Sv 		abnormal bone trabecula morphology J:201597
decreased bone mass J:201597
Lrp5tm3.2Mawa/Lrp5tm3.2Mawa
involves: 129S1/Sv * C57BL/6J * FVB/N * SJL 		decreased bone mass J:172746
Lrp5tvrm111B/Lrp5tvrm111B
C57BL/6J-Lrp5tvrm111b/Pjn 		abnormal blood-retina barrier function J:241491
abnormal cone electrophysiology J:241491
abnormal retina neuronal layer morphology J:241491
abnormal retina vasculature morphology J:241491
decreased a-wave amplitude J:241491
decreased areal bone mineral density J:241491
decreased b-wave amplitude J:241491
decreased bone mineral content J:241491
persistence of hyaloid vascular system J:241491
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory